Construction of a New Ferroptosis-related Prognosis Model for Survival Prediction in Colorectal Cancer
CONCLUSIONS: The present molecular signature established based on the 11 ferroptosis-related genes performed well in assessing CRC prognosis. The present discoveries could inspire further research on ferroptosis, providing a new direction for CRC management.PMID:38362684 | DOI:10.2174/0109298673296767240116215814 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Lin Chen Mengxiao Ge Shaocong Mo Menglin Shi Jun Zhang Jie Liu Source Type: research

Evolution and Trends of Aptamers in Cancer Research: A Bibliometric Analysis of the Literature over the Last Decade
CONCLUSION: The field of aptamers in cancer research has been steadily developing over the past decade, and future research may focus on aptamer application in cancer detection and therapy and the improvement of aptamer selection.PMID:38362685 | DOI:10.2174/0109298673280993240125091756 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Song Jiang Mao-Sheng Liu Ting Wang Kun-He Zhang Source Type: research

Natural Products in Liver Fibrosis Management: A Five-year Review
Curr Med Chem. 2024 Feb 14. doi: 10.2174/0109298673288458240203064112. Online ahead of print.ABSTRACTLiver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Not...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Tao Wang Zhuo Lu Gui-Feng Sun Kai-Yi He Zhi-Ping Chen Xin-Hui Qu Xiao-Jian Han Source Type: research

Does Gut Microbiome have an Effect on Wilson's Disease Phenotype?
This study may offer novel insights for further investigation into the mechanisms underlying the occurrence, development, and treatment of WD subtypes.PMID:38362687 | DOI:10.2174/0109298673282452240122103156 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Shan Gao Mei Zhou Hedong Zhang Zhenchu Tang Source Type: research

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery
In conclusion, the article highlights the challenges associated with cytoplasmic delivery and the importance of understanding the mechanisms involved in endosomal escape. A better understanding of these processes could result in the creation of greater effectiveness and safe delivery systems for various cargoes, including proteins, peptides, and nucleic acids.PMID:38362688 | DOI:10.2174/0109298673278936240107121907 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Sakshi Soni Shivam K Kori Priyanshu Nema Arun K Iyer Vandana Soni Sushil K Kashaw Source Type: research

Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth Factor for C57BL/6 Mice
CONCLUSION: The MXD-NPs-receiving mice exhibited a greater rate of anagen/telogen follicular when compared with MXD-treated types, which verified the improvement of their hair re-growing and follicular-stimulative activities. Therefore, these outcomes confirmed the potential of MXD-NPs for substituting its commercial solution format as a safe and efficient iso-formulation structure.PMID:38362689 | DOI:10.2174/0109298673283413240116065844 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Ali Moradi Seyed Morteza Seifati Majid Darroudi Shiva Golmohammadzadeh Mahmood Dehghani Ashkezari Source Type: research

Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways
CONCLUSION: The anticancer effects of HSE in BLCA may be attributed to its coordination of actions, inhibiting cell proliferation, migration, and invasion, inducing apoptosis, G0/G1 phase arrest, generating reactive oxygen species, causing MMP loss, and engaging the caspase protein family. These actions are likely mediated through the PI3K/AKT/FoxO3a and ER stress-mitochondrial pathways. Thus, our findings suggest that HSE is a promising novel therapeutic candidate for the prevention and treatment of BLCA.PMID:38357946 | DOI:10.2174/0109298673283888231217174702 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Yao Su Lin Chen Jin Yang Source Type: research

Discovery of Pyroptosis-inducing Drugs and Antineoplastic Activity Based on the ROS/ER Stress/Pyroptosis Axis
CONCLUSION: Compound 7 exhibits antineoplastic activity by regulating the ROS/ER stress/pyroptosis axis and is a kind of promising pyroptosis inducer.PMID:38357947 | DOI:10.2174/0109298673281684240102072157 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Gan Jingwen Xie Zhaojun Dong Yuna Wu Xiaoqing Zeng Zhenzhen Yang Bo Liu Min Zhu Bozhen Wang Wulan Li Ledan Wang Huajie Zhang Jianzhang Wu Yue Hu Source Type: research

Prediction Model for Therapeutic Responses in Ovarian Cancer Patients Using Paclitaxel-Resistant Immune-Related lncRNAs
CONCLUSION: The novel prediction model with 9 DEir-lncRNAs is a valuable tool for predicting immunotherapeutic and chemotherapeutic responses and prognosis of patients with OC.PMID:38357948 | DOI:10.2174/0109298673281438231217151129 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Li Huiqiang Liu Fanchen Wang Jia Yuan Wencai Guan Guoxiong Xu Source Type: research

Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections
CONCLUSION: The identified drugs can be repurposed against Gram-positive and Gramnegative bacterial infections. However, further experimental studies are required to confirm their antibacterial potential.PMID:38357949 | DOI:10.2174/0109298673296749240207115303 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Debanjan Dey Anoop Kumar Source Type: research

Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways
CONCLUSION: The anticancer effects of HSE in BLCA may be attributed to its coordination of actions, inhibiting cell proliferation, migration, and invasion, inducing apoptosis, G0/G1 phase arrest, generating reactive oxygen species, causing MMP loss, and engaging the caspase protein family. These actions are likely mediated through the PI3K/AKT/FoxO3a and ER stress-mitochondrial pathways. Thus, our findings suggest that HSE is a promising novel therapeutic candidate for the prevention and treatment of BLCA.PMID:38357946 | DOI:10.2174/0109298673283888231217174702 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Yao Su Lin Chen Jin Yang Source Type: research

Discovery of Pyroptosis-inducing Drugs and Antineoplastic Activity Based on the ROS/ER Stress/Pyroptosis Axis
CONCLUSION: Compound 7 exhibits antineoplastic activity by regulating the ROS/ER stress/pyroptosis axis and is a kind of promising pyroptosis inducer.PMID:38357947 | DOI:10.2174/0109298673281684240102072157 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Gan Jingwen Xie Zhaojun Dong Yuna Wu Xiaoqing Zeng Zhenzhen Yang Bo Liu Min Zhu Bozhen Wang Wulan Li Ledan Wang Huajie Zhang Jianzhang Wu Yue Hu Source Type: research

Prediction Model for Therapeutic Responses in Ovarian Cancer Patients Using Paclitaxel-Resistant Immune-Related lncRNAs
CONCLUSION: The novel prediction model with 9 DEir-lncRNAs is a valuable tool for predicting immunotherapeutic and chemotherapeutic responses and prognosis of patients with OC.PMID:38357948 | DOI:10.2174/0109298673281438231217151129 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Li Huiqiang Liu Fanchen Wang Jia Yuan Wencai Guan Guoxiong Xu Source Type: research

Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections
CONCLUSION: The identified drugs can be repurposed against Gram-positive and Gramnegative bacterial infections. However, further experimental studies are required to confirm their antibacterial potential.PMID:38357949 | DOI:10.2174/0109298673296749240207115303 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Debanjan Dey Anoop Kumar Source Type: research

Modulation of the HIF-1 α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-Hepatic Fibrosis Mechanism of Curcumol
CONCLUSION: Overall, curcumol induces ferroptosis and cellular senescence by increasing HIF-1α expression and increasing NCOA4 interaction with FTH1, leading to massive deposition of LIP and iron ions, which may be the molecular biological mechanism of its anti-liver fibrosis.PMID:38351696 | DOI:10.2174/0109298673271261231213051410 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 14, 2024 Category: Chemistry Authors: Yang Zheng Lei Wang Jiaru Wang Tiejian Zhao Jiahui Wang Source Type: research