NADP+/NADPH in Metabolism and its Relation to Cardiovascular Pathologies
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673275187231121054541. Online ahead of print.ABSTRACTThe nicotinamide adenine dinucleotide phosphate (NADP+/NADPH) redox couple serves as a substrate or cofactor for many enzymes to maintain cellular redox homeostasis as well as to regulate biosynthetic metabolism. The deficiency or imbalance of NADP+/NADPH redox couple is strongly associated with cardiovascular-related pathologies. An imbalance in the NADP+/NADPH ratio can lead to either oxidative or reductive stress. Reductive stress complicates the cellular redox environment and provides new insights into the cellular redo...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Yuanyuan Sun Dan Wu Qingxun Hu Source Type: research

Alterations in Adipocytokine Signaling Pathway and Pyroptosis in Neonatal Hypoxic-ischemic Encephalopathy
CONCLUSION: These results indicated that the adipocytokine signaling pathway may promote HIE occurrence by upregulating the expression of pyroptosis-related genes, providing a novel mechanism for HIE.PMID:38549539 | DOI:10.2174/0109298673293975240214091034 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Min Ran Li Yin Yatu Guo Wei Zhang Source Type: research

Multi-omics Data Integration Analysis Identified Therapeutic Targets and Potential Reuse Drugs for Osteoporosis
CONCLUSION: This study provided a new network-based framework for drug reuse and identified initial insights into therapeutic agents targeting CD74 in osteoporosis, which may be meaningful for promoting the development of osteoporosis treatment.PMID:38551048 | DOI:10.2174/0109298673291526240322081017 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Mingdong Li Xing Gao Yuchen Zhang Jinglei Wang Run Dong Peng Li Yongxiong He Source Type: research

Fragment-based Drug Discovery Strategy and its Application to the Design of SARS-CoV-2 Main Protease Inhibitor
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673294251240229070740. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) emerged at the end of 2019, causing a highly infectious and pathogenic disease known as 2019 coronavirus disease. This disease poses a serious threat to human health and public safety. The SARS-CoV-2 main protease (Mpro) is a highly sought-after target for developing drugs against COVID-19 due to its exceptional specificity. Its crystal structure has been extensively documented. Numerous strategies have been employed in the investigation of Mpro inhibitors. T...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yu Jiang Yingnan Wu Jing Wang Yuheng Ma Hui Yu Zhanli Wang Source Type: research

Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673287448240311112523. Online ahead of print.ABSTRACTCarbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the functions of CBNM are increasingly developed, their excellent imaging properties and superior tumor treatment eff...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yan Xing Rui Jing Jun Kang Yuwen Li Hui Zhang Xiaoying Tang Zhenqi Jiang Source Type: research

A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients
CONCLUSIONS: We used bioinformatics to determine a new, robust sixteen-gene signature. We also found that this signature's prognostic ability was closely related to the resting mast cell infiltration of LUAD patients.PMID:38529604 | DOI:10.2174/0109298673293174240320053546 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Chao Ma Source Type: research

Role of ABCA1 in Atherosclerosis: Novel Mutations and Potential Plant-derived Therapies
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673291917240315113845. Online ahead of print.ABSTRACTATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological fu...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Siarhei A Dabravolski Nikolay A Orekhov Victor Y Glanz Vasily N Sukhorukov Elizaveta M Pleshko Alexander N Orekhov Source Type: research

Fragment-based Drug Discovery Strategy and its Application to the Design of SARS-CoV-2 Main Protease Inhibitor
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673294251240229070740. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) emerged at the end of 2019, causing a highly infectious and pathogenic disease known as 2019 coronavirus disease. This disease poses a serious threat to human health and public safety. The SARS-CoV-2 main protease (Mpro) is a highly sought-after target for developing drugs against COVID-19 due to its exceptional specificity. Its crystal structure has been extensively documented. Numerous strategies have been employed in the investigation of Mpro inhibitors. T...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yu Jiang Yingnan Wu Jing Wang Yuheng Ma Hui Yu Zhanli Wang Source Type: research

Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673287448240311112523. Online ahead of print.ABSTRACTCarbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the functions of CBNM are increasingly developed, their excellent imaging properties and superior tumor treatment eff...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yan Xing Rui Jing Jun Kang Yuwen Li Hui Zhang Xiaoying Tang Zhenqi Jiang Source Type: research

A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients
CONCLUSIONS: We used bioinformatics to determine a new, robust sixteen-gene signature. We also found that this signature's prognostic ability was closely related to the resting mast cell infiltration of LUAD patients.PMID:38529604 | DOI:10.2174/0109298673293174240320053546 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Chao Ma Source Type: research

Role of ABCA1 in Atherosclerosis: Novel Mutations and Potential Plant-derived Therapies
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673291917240315113845. Online ahead of print.ABSTRACTATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological fu...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Siarhei A Dabravolski Nikolay A Orekhov Victor Y Glanz Vasily N Sukhorukov Elizaveta M Pleshko Alexander N Orekhov Source Type: research

Fragment-based Drug Discovery Strategy and its Application to the Design of SARS-CoV-2 Main Protease Inhibitor
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673294251240229070740. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) emerged at the end of 2019, causing a highly infectious and pathogenic disease known as 2019 coronavirus disease. This disease poses a serious threat to human health and public safety. The SARS-CoV-2 main protease (Mpro) is a highly sought-after target for developing drugs against COVID-19 due to its exceptional specificity. Its crystal structure has been extensively documented. Numerous strategies have been employed in the investigation of Mpro inhibitors. T...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yu Jiang Yingnan Wu Jing Wang Yuheng Ma Hui Yu Zhanli Wang Source Type: research

Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673287448240311112523. Online ahead of print.ABSTRACTCarbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the functions of CBNM are increasingly developed, their excellent imaging properties and superior tumor treatment eff...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Yan Xing Rui Jing Jun Kang Yuwen Li Hui Zhang Xiaoying Tang Zhenqi Jiang Source Type: research

A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients
CONCLUSIONS: We used bioinformatics to determine a new, robust sixteen-gene signature. We also found that this signature's prognostic ability was closely related to the resting mast cell infiltration of LUAD patients.PMID:38529604 | DOI:10.2174/0109298673293174240320053546 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Chao Ma Source Type: research

Role of ABCA1 in Atherosclerosis: Novel Mutations and Potential Plant-derived Therapies
Curr Med Chem. 2024 Mar 25. doi: 10.2174/0109298673291917240315113845. Online ahead of print.ABSTRACTATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological fu...
Source: Current Medicinal Chemistry - March 26, 2024 Category: Chemistry Authors: Siarhei A Dabravolski Nikolay A Orekhov Victor Y Glanz Vasily N Sukhorukov Elizaveta M Pleshko Alexander N Orekhov Source Type: research