Pharmacokinetics of Anti-Rheumatic drugs Methotrexate and Tofacitinib with its metabolite M9 in Rats by UPLC-MS/MS

CONCLUSION: The currently established analytical method exhibited great potential for the evaluation of plasma concentrations of methotrexate, tofacitinib and M9 simultaneously, greatly reducing the detection time, which would serve as a supplementary role in formulating dose decisions to achieve personalized treatment, identify drugs that cause adverse reactions and finally, to assess drug-drug interactions on clinical studies.PMID:38310397 | DOI:10.2174/0109298673256258231219060950

Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Er-Min Gu Lingjie Xue Chenjian Zhou Yang Xia Ge-Xin Dai Source Type: research