Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors

Curr Med Chem. 2024 Jan 2. doi: 10.2174/0109298673289984231127062528. Online ahead of print.ABSTRACTInflammasomes are multimeric protein complexes that can detect various phys-iological stimuli and danger signals. As a result, they perform a crucial function in the in-nate immune response. The NLRP3 inflammasome, as a vital constituent of the inflam-masome family, is significant in defending against pathogen invasion and preserving cell-homeostasis. NLRP3 inflammasome dysregulation is connected to various pathological conditions, including inflammatory diseases, cancer, and cardiovascular and neurodegen-erative diseases. This profile makes NLRP3 an applicable target for treating related dis-eases, and therefore, there are rising NLRP3 inhibitors disclosed for therapy. Herein, we summarized the updated advances in the structure, function, and inhibitors of NLRP3 in-flammasome. Moreover, we aimed to provide an overview of the existing products and fu-ture directions for drug research and development.PMID:38310392 | DOI:10.2174/0109298673289984231127062528

Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Shengying Lou Miaolian Wu Sunliang Cui Source Type: research