Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea
CONCLUSION: The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperative to sustain comprehensive studies and ongoing policy support for the virus to enhance the prognosis for individuals affected by COVID-19.PMID:38622937 | DOI:10.3346/jkms.2024.39.e128 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 16, 2024 Category: General Medicine Authors: Jae Kyeom Sim Hye Sun Lee Juyeon Yang Jin Gwack Bryan Inho Kim Jeong-Ok Cha Kyung Hoon Min Young Seok Lee Severe Acute Respiratory Infection (SARI) Investigators Source Type: research
RSV Disease Burden in Primary Care in Italy: A Multi-Region Pediatric Study, Winter Season 2022-2023
CONCLUSIONS: Our findings describe a baseline of the RSV disease burden in primary care in Italy before the introduction of upcoming immunization strategies.PMID:38622776 | DOI:10.1111/irv.13282 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Michela Scarpaci Sara Bracaloni Enrica Esposito Luigi De Angelis Francesco Baglivo Beatrice Casini Donatella Panatto Matilde Ogliastro Daniela Loconsole Maria Chironna Elena Pariani Laura Pellegrinelli Elisabetta Pandolfi Ileana Croci Caterina Rizzo RSVCo Source Type: research
Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020)
CONCLUSIONS: In individuals with LTBI not receiving TPT, experiencing an influenza episode may elevate the risk of developing active TB.PMID:38627123 | DOI:10.1016/j.jmii.2024.04.003 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 16, 2024 Category: Microbiology Authors: Jaehee Lee Hyewon Seo Dohyang Kim Jinseub Hwang Jin-Won Kwon Source Type: research
Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea
CONCLUSION: The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperative to sustain comprehensive studies and ongoing policy support for the virus to enhance the prognosis for individuals affected by COVID-19.PMID:38622937 | DOI:10.3346/jkms.2024.39.e128 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 16, 2024 Category: Biomedical Science Authors: Jae Kyeom Sim Hye Sun Lee Juyeon Yang Jin Gwack Bryan Inho Kim Jeong-Ok Cha Kyung Hoon Min Young Seok Lee Severe Acute Respiratory Infection (SARI) Investigators Source Type: research
The immunodominance of antigenic site Sb on the H1 influenza virus hemagglutinin increases with high immunoglobulin titers of the cohorts and with young age, but not sex
Vaccine. 2024 Apr 15:S0264-410X(24)00451-1. doi: 10.1016/j.vaccine.2024.04.037. Online ahead of print.ABSTRACTThe head domain of the hemagglutinin of influenza viruses plays a dominant role in the antibody response due to the presence of immunodominant antigenic sites that are the main targets of host neutralizing antibodies. For the H1 hemagglutinin, five major antigenic sites defined as Sa, Sb, Ca1, Ca2, and Cb have been described. Although previous studies have focused on defining the hierarchy of the antigenic sites of the hemagglutinin in different human cohorts, it is still unclear if the immunodominance profile of t...
Source: Vaccine - April 16, 2024 Category: Allergy & Immunology Authors: Jose L Mart ínez Nicholas Lemus Tsoi Ying Lai Mitali Mishra Irene Gonz ález-Domínguez Eduard Puente-Massaguer Madhumathi Loganathan Benjamin Francis Marie I Samanovic Florian Krammer Mark J Mulligan Viviana Simon Peter Palese Weina Sun Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
RSV Disease Burden in Primary Care in Italy: A Multi-Region Pediatric Study, Winter Season 2022-2023
CONCLUSIONS: Our findings describe a baseline of the RSV disease burden in primary care in Italy before the introduction of upcoming immunization strategies.PMID:38622776 | PMC:PMC11018906 | DOI:10.1111/irv.13282 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Michela Scarpaci Sara Bracaloni Enrica Esposito Luigi De Angelis Francesco Baglivo Beatrice Casini Donatella Panatto Matilde Ogliastro Daniela Loconsole Maria Chironna Elena Pariani Laura Pellegrinelli Elisabetta Pandolfi Ileana Croci Caterina Rizzo RSVCo Source Type: research
Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020)
CONCLUSIONS: In individuals with LTBI not receiving TPT, experiencing an influenza episode may elevate the risk of developing active TB.PMID:38627123 | DOI:10.1016/j.jmii.2024.04.003 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 16, 2024 Category: Microbiology Authors: Jaehee Lee Hyewon Seo Dohyang Kim Jinseub Hwang Jin-Won Kwon Source Type: research
Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea
CONCLUSION: The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperative to sustain comprehensive studies and ongoing policy support for the virus to enhance the prognosis for individuals affected by COVID-19.PMID:38622937 | PMC:PMC11018986 | DOI:10.3346/jkms.2024.39.e128 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 16, 2024 Category: Biomedical Science Authors: Jae Kyeom Sim Hye Sun Lee Juyeon Yang Jin Gwack Bryan Inho Kim Jeong-Ok Cha Kyung Hoon Min Young Seok Lee Severe Acute Respiratory Infection (SARI) Investigators Source Type: research
Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea
CONCLUSION: The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperative to sustain comprehensive studies and ongoing policy support for the virus to enhance the prognosis for individuals affected by COVID-19.PMID:38622937 | PMC:PMC11018986 | DOI:10.3346/jkms.2024.39.e128 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 16, 2024 Category: General Medicine Authors: Jae Kyeom Sim Hye Sun Lee Juyeon Yang Jin Gwack Bryan Inho Kim Jeong-Ok Cha Kyung Hoon Min Young Seok Lee Severe Acute Respiratory Infection (SARI) Investigators Source Type: research
Molecular characterization of the whole genome of H9N2 avian influenza virus isolated from Egyptian poultry farms
In this study, we sequenced the entire genome of AIV H9N2 isolated from chickens in Egypt in 2021, using next-generation sequencing (NGS) technology. Phylogenetic analysis of the resulting sequences showed that the studied strain was generally monophyletic and grouped within the G1 sublineage of the Eurasian lineage. Four segments (polymerase basic 2 [PB2], polymerase basic 1 [PB1], polymerase acidic [PA], and non-structural [NS]) were related to Egyptian genotype II, while the nucleoprotein (NP), neuraminidase (NA), matrix (M), and haemagglutinin (HA) segments were related to Egyptian genotype I. Molecular analysis reveal...
Source: Archives of Virology - April 16, 2024 Category: Virology Source Type: research
Global analysis of respiratory viral circulation and timing of epidemics in the pre-COVID-19 and COVID-19 pandemic eras, based on data from the Global Influenza Surveillance and Response System (GISRS)
The emergence of the COVID-19 pandemic, caused by SARS-CoV-2, has undeniably reshaped life on a global scale. As infection rates and fatalities surged to historic proportions, initial strategies to combat the crisis revolved around non-pharmaceutical interventions (NPIs) such as the use of facemasks, physical distancing, travel bans, and lockdowns, considering the absence of available vaccines or targeted therapeutics. Characterized by a spectrum of actions spanning individual precautions to broader societal measures, NPIs aimed to curtail the rapid dissemination of the virus [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi, Chiara Lorini, John Paget, Koos van der Velden, Adam Meijer, Mendel Haag, Ian McGovern, Patrizio Zanobini Source Type: research
COVID-19 Vaccine Hesitancy Among People Living with HIV: A Systematic Review and Meta-Analysis
AbstractVaccine hesitancy is one of the top 10 threats to global health, which affects the prevalence and fatality of vaccine-preventable diseases over the world. During the COVID-19 pandemic, people living with HIV (PLWH) may have higher risks of infection, more serious complications, and worse prognosis without the protection of the COVID-19 vaccine. A systematic review and meta-analysis aiming to evaluate the prevalence of COVID-19 vaccine hesitancy among PLWH was conducted using PubMed, Embase, and Web of Science databases for studies published between January 1, 2020, and August 31, 2022. The pooled prevalence with a ...
Source: AIDS and Behavior - April 16, 2024 Category: Infectious Diseases Source Type: research
Etiology of bacterial pneumonia and multi-drug resistance pattern among pneumonia suspected patients in Ethiopia: a systematic review and meta-analysis
Bacterial pneumonia can affect all age groups, but people with weakened immune systems, young children, and the elderly are at a higher risk. Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenza... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Mihret Tilahun, Melaku Ashagrie Belete, Alemu Gedefie, Habtu Debash, Ermiyas Alemayehu, Daniel Gebretsadik, Hussein Ebrahim and Ousman Mohammed Tags: Research Source Type: research
