Blocking cell death limits lung damage and inflammation from influenza
Nature, Published online: 10 April 2024; doi:10.1038/d41586-024-00910-2Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases. (Source: Nature AOP)
Source: Nature AOP - April 10, 2024 Category: Research Authors: Nishma Gupta John Silke Source Type: research
Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China
Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating preva... (Source: Virology Journal)
Source: Virology Journal - April 10, 2024 Category: Virology Authors: Jinyue He, Jing Deng, Xianxian Wen, Mengyuan Yan, Yang Liu, Yunqiu Zhou, XuBin Du, Han Yang and Xiaobin Peng Tags: Research Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Identification of common genes of rhinovirus single/double ‑stranded RNA‑induced asthma deterioration by bioinformatics analysis
Exp Ther Med. 2024 Mar 20;27(5):210. doi: 10.3892/etm.2024.12498. eCollection 2024 May.ABSTRACTRhinovirus (RV) is the most common respiratory virus affecting humans. The majority of asthma deteriorations are triggered by RV infections. However, whether the effects of RV single- and double-stranded RNA on asthma deterioration have common target genes needs to be further studied. In the present study, two datasets (GSE51392 and GSE30326) were used to screen for common differentially expressed genes (cDEGs). The molecular function, signaling pathways, interaction networks, hub genes, key modules and regulatory molecules of cD...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Qian An Yi Cao Wei Guo Ziyun Jiang Hui Luo Hui Liu Xiaodong Zhan Source Type: research
Generation and characterization of a nanobody against the avian influenza virus H7 subtype
This study screened a strain of Nb with high hemagglutination inhibition activity and enhanced its antiviral activity through oligomerization, which may have great potential for developing effective agents for the prevention, diagnosis, and treatment of AIV H7 subtype infection.PMID:38593899 | DOI:10.1016/j.ijbiomac.2024.131458 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Xiuqin Huang Weiye Li Xuewei Cao Qi Zhang Yizhen Lin Siqi Xu Xinying Dong Peiqi Liu Yutong Liu Ge He Kaijian Luo Saixiang Feng Source Type: research
Relative Humidity-Dependent Phase Transitions in Submicron Respiratory Aerosols
J Phys Chem A. 2024 Apr 9. doi: 10.1021/acs.jpca.4c00691. Online ahead of print.ABSTRACTRespiratory viruses, such as influenza and severe acute respiratory syndrome coronavirus 2, represent a substantial public health burden and are largely transmitted through respiratory droplets and aerosols. Environmental factors such as relative humidity (RH) and temperature impact virus transmission rates, and a precise mechanistic understanding of the connection between these environmental factors and virus transmission would improve efforts to mitigate respiratory disease transmission. Previous studies on supermicrometer particles o...
Source: Health Physics - April 9, 2024 Category: Physics Authors: Angel M Gibbons Paul E Ohno Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, March 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the conti...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
A comparative analysis of knowledge, attitude, and practice (KAP) towards influenza and influenza vaccination among healthcare workers in Kyrgyzstan prior to and during the COVID-19 pandemic
CONCLUSION: Our investigation provides valuable insights into HCWs KAP concerning influenza vaccination in Kyrgyzstan, highlighting the need for targeted interventions addressing factors influencing vaccine acceptance. The study suggests policy implications, advocating for the revision of national strategies to strengthen capacity building for medical staff.PMID:38594119 | DOI:10.1016/j.vaccine.2024.04.008 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Rakhat Akmatova Malembe S Ebama Sanjar Temirbekov Venera Alymkulova Dinara Otorbaeva Source Type: research
Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia: A multicenter retrospective study
CONCLUSION: In Saudi Arabia, patients with DM showed higher vaccination rates for annual influenza and COVID-19 vaccines compared to other vaccinations such as herpes zoster, Tdap, pneumococcal, and HPV. Factors such as vaccine recommendations provided by family physicians or specialists, the site of care, income level, DM-related hospitalization history, residency site, HbA1c level, and health sector type can significantly influence the vaccination rate in patients with DM.PMID:38591075 | PMC:PMC10999047 | DOI:10.4239/wjd.v15.i3.440 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Source Type: research
Immunological Profiles in Parry-Romberg Syndrome: A Case-Control Study
Conclusions: Our case-control study is the first to compare the immunological profiles of PRS and scleroderma patients. The higher percentage of Th17 cells in PRS suggests the use of anti-IL17 receptor monoclonal antibody in this rare disease; however, further studies with larger numbers of patients are needed to confirm our findings.PMID:38592689 | PMC:PMC10932088 | DOI:10.3390/jcm13051219 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 9, 2024 Category: Information Technology Authors: Irma Saulle Antonio Gidaro Mattia Donadoni Claudia Vanetti Alessandra Mutti Maria Eva Romano Mario Clerici Chiara Cogliati Mara Biasin Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Generation and characterization of a nanobody against the avian influenza virus H7 subtype
This study screened a strain of Nb with high hemagglutination inhibition activity and enhanced its antiviral activity through oligomerization, which may have great potential for developing effective agents for the prevention, diagnosis, and treatment of AIV H7 subtype infection.PMID:38593899 | DOI:10.1016/j.ijbiomac.2024.131458 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Xiuqin Huang Weiye Li Xuewei Cao Qi Zhang Yizhen Lin Siqi Xu Xinying Dong Peiqi Liu Yutong Liu Ge He Kaijian Luo Saixiang Feng Source Type: research
Relative Humidity-Dependent Phase Transitions in Submicron Respiratory Aerosols
J Phys Chem A. 2024 Apr 9. doi: 10.1021/acs.jpca.4c00691. Online ahead of print.ABSTRACTRespiratory viruses, such as influenza and severe acute respiratory syndrome coronavirus 2, represent a substantial public health burden and are largely transmitted through respiratory droplets and aerosols. Environmental factors such as relative humidity (RH) and temperature impact virus transmission rates, and a precise mechanistic understanding of the connection between these environmental factors and virus transmission would improve efforts to mitigate respiratory disease transmission. Previous studies on supermicrometer particles o...
Source: Health Physics - April 9, 2024 Category: Physics Authors: Angel M Gibbons Paul E Ohno Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, March 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the conti...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
A comparative analysis of knowledge, attitude, and practice (KAP) towards influenza and influenza vaccination among healthcare workers in Kyrgyzstan prior to and during the COVID-19 pandemic
CONCLUSION: Our investigation provides valuable insights into HCWs KAP concerning influenza vaccination in Kyrgyzstan, highlighting the need for targeted interventions addressing factors influencing vaccine acceptance. The study suggests policy implications, advocating for the revision of national strategies to strengthen capacity building for medical staff.PMID:38594119 | DOI:10.1016/j.vaccine.2024.04.008 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Rakhat Akmatova Malembe S Ebama Sanjar Temirbekov Venera Alymkulova Dinara Otorbaeva Source Type: research
