The Role of Human Mobility Flow in the Region-to-Region Spread of Respiratory Syncytial Virus Infection among Infants: An Infographic Analysis
In this study, we investigated the correlation between the trend of regional reports of the pediatric RSV infections and the HMF based on cellular phone signal data. Upon closer examination of both epidemiological trend and HMF data, the spread of pediatric RSV infection from one region to another was logically explained by HMF, which would serve as the evidence of the dependence of regional transmission on HMF. This is the first solid evidence where this correlation has been clearly observed for the common respiratory infections. While social implementation of infection control measures has successfully suppressed the dro...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Hide Sasaki Ryo Seoka Mayuko Yagi Jun Komano Source Type: research
The Role of Human Mobility Flow in the Region-to-Region Spread of Respiratory Syncytial Virus Infection among Infants: An Infographic Analysis
In this study, we investigated the correlation between the trend of regional reports of the pediatric RSV infections and the HMF based on cellular phone signal data. Upon closer examination of both epidemiological trend and HMF data, the spread of pediatric RSV infection from one region to another was logically explained by HMF, which would serve as the evidence of the dependence of regional transmission on HMF. This is the first solid evidence where this correlation has been clearly observed for the common respiratory infections. While social implementation of infection control measures has successfully suppressed the dro...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Hide Sasaki Ryo Seoka Mayuko Yagi Jun Komano Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Size effect of mesoporous silica nanoparticles on regulating the immune effect of oral influenza split vaccine
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113920. doi: 10.1016/j.colsurfb.2024.113920. Online ahead of print.ABSTRACTMucosal immunization is a powerful weapon against viral infection. In this paper, large pore mesoporous silica nanoparticles (LMSN) with different particle sizes were synthesized for loading influenza split vaccine (SV) to explore the effect of nanoparticle sizes on mucosal immunization and adjuvant efficacy. Interestingly, it was found that among the three particle sizes of nanoparticles, only LMSN-M with around 250 nm could significantly enhance the mucosal immune effect of SV, possessing adjuvant eff...
Source: Colloids and Surfaces - April 30, 2024 Category: Biotechnology Authors: Zhu Liu Hongyan Lu Shi Li Bin Liu Qinfu Zhao Yikun Gao Yuling Mao Jinghai Zhang Siling Wang Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Effects of parental childhood cultural health environment on children's influenza and COVID-19 vaccination status
We examined whether the childhood cultural health environment (CHE) of parents (measured by self-reported regular attendance at doctor and dentist visits during childhood) was associated with flu and COVID-19 vaccination of their children. Using 2023 survey data from 397 US parents and causal inference methods, we estimated the average causal effect of parental CHE on flu vaccination rates (0.16 [95 % confidence interval: 0.06,0.27]) and COVID-19 (0.14 [95 % confidence interval: 0.04,0.24]), indicating that if all parents had attended regular doctor/dentist visits as children, flu and COVID-19 vaccination rates in children...
Source: Vaccine - April 30, 2024 Category: Allergy & Immunology Authors: Sasha A Fleary Zachary Shahn Chloe A Teasdale Source Type: research
Size effect of mesoporous silica nanoparticles on regulating the immune effect of oral influenza split vaccine
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113920. doi: 10.1016/j.colsurfb.2024.113920. Online ahead of print.ABSTRACTMucosal immunization is a powerful weapon against viral infection. In this paper, large pore mesoporous silica nanoparticles (LMSN) with different particle sizes were synthesized for loading influenza split vaccine (SV) to explore the effect of nanoparticle sizes on mucosal immunization and adjuvant efficacy. Interestingly, it was found that among the three particle sizes of nanoparticles, only LMSN-M with around 250 nm could significantly enhance the mucosal immune effect of SV, possessing adjuvant eff...
Source: Colloids and Surfaces - April 30, 2024 Category: Biotechnology Authors: Zhu Liu Hongyan Lu Shi Li Bin Liu Qinfu Zhao Yikun Gao Yuling Mao Jinghai Zhang Siling Wang Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
AbstractInfluenza-associated encephalopathy (IAE) is extremely acute in onset, with high lethality and morbidity within a few days, while the direct pathogenesis by influenza virus in this acute phase in the brain is largely unknown. Here we show that influenza virus enters into the cerebral endothelium and thereby induces IAE. Three-weeks-old young mice were inoculated with influenza A virus (IAV). Physical and neurological scores were recorded and temporal-spatial analyses of histopathology and viral studies were performed up to 72 h post inoculation. Histopathological examinations were also performed using IAE human a...
Source: Acta Neuropathologica - April 30, 2024 Category: Neurology Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024
We report highly pathogenic avian influenza A(H5N1) virus in dairy cattle and cats in Kansas and Texas, United States, which reflects the continued spread of clade 2.3.4.4b viruses that entered the country in late 2021. Infected cattle experienced nonspecific illness, reduced feed intake and rumination, and an abrupt drop in milk production, but fatal systemic influenza infection developed in domestic cats fed raw (unpasteurized) colostrum and milk from affected cows. Cow-to-cow transmission appears to have occurred because infections were observed in cattle on Michigan, Idaho, and Ohio farms where avian influenza virus-in...
Source: Emerging Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Eric R Burrough Drew R Magstadt Barbara Petersen Simon J Timmermans Phillip C Gauger Jianqiang Zhang Chris Siepker Marta Mainenti Ganwu Li Alexis C Thompson Patrick J Gorden Paul J Plummer Rodger Main Source Type: research
Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
CONCLUSIONS: Our data provides support for inhaled ethanol as a candidate treatment for respiratory infections.PMID:38683138 | DOI:10.1080/01902148.2024.2346320 (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 29, 2024 Category: Respiratory Medicine Authors: David G Hancock Luke Berry Naomi M Scott Kyle T Mincham William Ditcham Alexander N Larcombe Barry Clements Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024
We report highly pathogenic avian influenza A(H5N1) virus in dairy cattle and cats in Kansas and Texas, United States, which reflects the continued spread of clade 2.3.4.4b viruses that entered the country in late 2021. Infected cattle experienced nonspecific illness, reduced feed intake and rumination, and an abrupt drop in milk production, but fatal systemic influenza infection developed in domestic cats fed raw (unpasteurized) colostrum and milk from affected cows. Cow-to-cow transmission appears to have occurred because infections were observed in cattle on Michigan, Idaho, and Ohio farms where avian influenza virus-in...
Source: Emerging Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Eric R Burrough Drew R Magstadt Barbara Petersen Simon J Timmermans Phillip C Gauger Jianqiang Zhang Chris Siepker Marta Mainenti Ganwu Li Alexis C Thompson Patrick J Gorden Paul J Plummer Rodger Main Source Type: research
Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
CONCLUSIONS: Our data provides support for inhaled ethanol as a candidate treatment for respiratory infections.PMID:38683138 | DOI:10.1080/01902148.2024.2346320 (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 29, 2024 Category: Respiratory Medicine Authors: David G Hancock Luke Berry Naomi M Scott Kyle T Mincham William Ditcham Alexander N Larcombe Barry Clements Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024
We report highly pathogenic avian influenza A(H5N1) virus in dairy cattle and cats in Kansas and Texas, United States, which reflects the continued spread of clade 2.3.4.4b viruses that entered the country in late 2021. Infected cattle experienced nonspecific illness, reduced feed intake and rumination, and an abrupt drop in milk production, but fatal systemic influenza infection developed in domestic cats fed raw (unpasteurized) colostrum and milk from affected cows. Cow-to-cow transmission appears to have occurred because infections were observed in cattle on Michigan, Idaho, and Ohio farms where avian influenza virus-in...
Source: Emerging Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Eric R Burrough Drew R Magstadt Barbara Petersen Simon J Timmermans Phillip C Gauger Jianqiang Zhang Chris Siepker Marta Mainenti Ganwu Li Alexis C Thompson Patrick J Gorden Paul J Plummer Rodger Main Source Type: research
