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The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Expert Review of Respiratory Medicine - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research

Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research

Safety and effectiveness of isavuconazole in real-life non-neutropenic patients
There is a notable change in the profile of patients with invasive fungal infections (IFI): there has been a progressive rise of such infections in non-neutropenic population (i.e., COVID-19, influenza, biologic agents, corticosteroids, cancer, chronic obstructive pulmonary disorder [COPD] or cirrhosis) [1 –3]. However, information concerning the management of non-neutropenic patients with IFI remains limited. Caution should be exercised before these patients are treated like those who are neutropenic, given a considerable variability in pathogenesis and clinical manifestations of IFI [4]. (Source: International Journal ...
Source: International Journal of Infectious Diseases - April 23, 2024 Category: Infectious Diseases Authors: Patricia Monz ó-Gallo, Carlos Lopera, Ana M Badía-Tejero, Marina Machado, Julio García-Rodríguez, Pablo Vidal-Cortés, Esperanza Merino, Jorge Calderón, Jesús Fortún, Zaira R. Palacios-Baena, Javier Pemán, Joan Roig Sanchis, Manuela Aguilar-Guisad Source Type: research

High-Dose Recombinant Influenza Vaccine: NNT = 3,000 to Prevent One More Infection, No Impact on Hospitalization
Am Fam Physician. 2024 Apr;109(4):372.NO ABSTRACTPMID:38648840 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Mark H Ebell Source Type: research

Errors in Results and Discussion
This article was corrected online. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research

Locations and structures of influenza A virus packaging-associated signals and other functional elements via an < i > in silico < /i > pipeline for predicting constrained features in RNA viruses
by Emma Beniston, Jordan P. Skittrall Influenza A virus contains regions of its segmented genome associated with ability to package the segments into virions, but many such regions are poorly characterised. We provide detailed predictions of the key locations within these packaging-associated regions, and their structures, by applying a recently-improved pipeline for delineating constrained regions in RNA viruses and applying structural prediction algorithms. We find and characterise other known constrained regions within influenza A genomes, including the region associated with the PA-X frameshift, regions associated wit...
Source: PLoS Computational Biology - April 22, 2024 Category: Biology Authors: Emma Beniston Source Type: research

Estimating the incidence of COVID-19, influenza and respiratory syncytial virus infection in three regions of Queensland, Australia, winter 2022: findings from a novel longitudinal testing-based sentinel surveillance programme
Conclusion This testing-based surveillance programme could estimate disease trends and be a useful tool in settings where testing is less common or accessible. Difficulties with recruitment meant the study was underpowered. The frontline sentinel nature of workplaces meant participants were not representative of the general population but were high-risk groups providing early warning of disease. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: May, F., Ginige, S., Firman, E., Li, Y. S., Soonarane, Y. K., Smoll, N., Hunter, I., Pery, B., Macfarlane, B., Bladen, T., Allen, T., Green, T., Walker, J., Slinko, V., Stickley, M., Khandaker, G., Anuradha, S., Wattiaux, A. Tags: Open access, Public health, COVID-19 Source Type: research