Tacrolimus, cyclosporine, and grapefruit: Friends or foes?
Transpl Immunol. 2022 Mar 20:101584. doi: 10.1016/j.trim.2022.101584. Online ahead of print.NO ABSTRACTPMID:35322792 | DOI:10.1016/j.trim.2022.101584 (Source: Transplant Immunology)
Source: Transplant Immunology - March 24, 2022 Category: Transplant Surgery Authors: Yuzi Cao Qilang Xiang Ziyi Hu Shiquan Shuai Anji Xiong Source Type: research
Tacrolimus, cyclosporine, and grapefruit: Friends or foes?
Transpl Immunol. 2022 Mar 20;72:101584. doi: 10.1016/j.trim.2022.101584. Online ahead of print.NO ABSTRACTPMID:35322792 | DOI:10.1016/j.trim.2022.101584 (Source: Transplant Immunology)
Source: Transplant Immunology - March 24, 2022 Category: Transplant Surgery Authors: Yuzi Cao Qilang Xiang Ziyi Hu Shiquan Shuai Anji Xiong Source Type: research
Tacrolimus, cyclosporine, and grapefruit: Friends or foes?
Transpl Immunol. 2022 Mar 20;72:101584. doi: 10.1016/j.trim.2022.101584. Online ahead of print.NO ABSTRACTPMID:35322792 | DOI:10.1016/j.trim.2022.101584 (Source: Transplant Immunology)
Source: Transplant Immunology - March 24, 2022 Category: Transplant Surgery Authors: Yuzi Cao Qilang Xiang Ziyi Hu Shiquan Shuai Anji Xiong Source Type: research
Protective effect of Naringin ameliorates TNBS-induced colitis in rats via improving antioxidant status and pro-inflammatory cytokines
This study examined the effect of NG on 2, 4, 6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. 42 male Wistar rats were divided into seven groups like Normal Control (NC), Ethanol Control (EC), Disease Control (DC), NG 20 (20 mg/kg, p.o.), NG 40 (40 mg/kg, p.o.), NG 80 (80 mg/kg, p.o.) and Dexamethasone (DEX) (2 mg/kg, p.o.). Colitis was induced in Wistar albino rats by administering TNBS intra-rectally (in 50% ethanol). The rats were then given 14 days of NG (20, 40, and 80 mg/kg) and DEX (2 mg/kg) treatment. Several behavioural, biochemical, molecular, and histological analyses were performed. The treatmen...
Source: Immunopharmacology and Immunotoxicology - March 7, 2022 Category: Allergy & Immunology Authors: Vrushali R Hambardikar Deepa S Mandlik Source Type: research
Antifungal activity of Zinc nitrate derived nano Zno fungicide synthesized from Trachyspermum ammi to control fruit rot disease of grapefruit
Ecotoxicol Environ Saf. 2022 Feb 23;233:113311. doi: 10.1016/j.ecoenv.2022.113311. Online ahead of print.ABSTRACTGrapefruit (Citrus paradisi) is a widely grown citrus and its fruit is affected by a variety of biotic and abiotic stress. Keeping in view the hazardous effects of synthetic fungicides, the recent trend is shifting towards safer and eco-friendly control of fruit diseases. The present study was aimed to diagnose the fruit rot disease of grapefruit and its control by using zinc oxide green nanoparticles (ZnO NPs). Fruit rot symptoms were observed in various grapefruit growing sites of Pakistan. Diseased samples we...
Source: Ecotoxicology and Environmental Safety - February 26, 2022 Category: Environmental Health Authors: Musrat Ali Xiukang Wang Urooj Haroon Hassan Javed Chaudhary Asif Kamal Qurban Ali Muhammad Hamzah Saleem Kamal Usman Aishah Alatawi Shafaqat Ali Muhammad Farooq Hussain Munis Source Type: research
Antifungal activity of Zinc nitrate derived nano Zno fungicide synthesized from Trachyspermum ammi to control fruit rot disease of grapefruit
Ecotoxicol Environ Saf. 2022 Feb 22;233:113311. doi: 10.1016/j.ecoenv.2022.113311. Online ahead of print.ABSTRACTGrapefruit (Citrus paradisi) is a widely grown citrus and its fruit is affected by a variety of biotic and abiotic stress. Keeping in view the hazardous effects of synthetic fungicides, the recent trend is shifting towards safer and eco-friendly control of fruit diseases. The present study was aimed to diagnose the fruit rot disease of grapefruit and its control by using zinc oxide green nanoparticles (ZnO NPs). Fruit rot symptoms were observed in various grapefruit growing sites of Pakistan. Diseased samples we...
Source: Ecotoxicology and Environmental Safety - February 26, 2022 Category: Environmental Health Authors: Musrat Ali Xiukang Wang Urooj Haroon Hassan Javed Chaudhary Asif Kamal Qurban Ali Muhammad Hamzah Saleem Kamal Usman Aishah Alatawi Shafaqat Ali Muhammad Farooq Hussain Munis Source Type: research
Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review
Mini Rev Med Chem. 2022 Feb 14. doi: 10.2174/1389557522666220214092005. Online ahead of print.ABSTRACTPlant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet n...
Source: Mini Reviews in Medicinal Chemistry - February 14, 2022 Category: Chemistry Authors: Ankush Kumar Jha Shobhit Gairola Sourav Kundu Pakpi Doye Abu Mohammad Syed Chetan Ram Uttam Kulhari Naresh Kumar Upadhyayula Suryanarayana Murty Bidya Dhar Sahu Source Type: research
Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review
Mini Rev Med Chem. 2022 Feb 14. doi: 10.2174/1389557522666220214092005. Online ahead of print.ABSTRACTPlant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet n...
Source: Mini Reviews in Medicinal Chemistry - February 14, 2022 Category: Chemistry Authors: Ankush Kumar Jha Shobhit Gairola Sourav Kundu Pakpi Doye Abu Mohammad Syed Chetan Ram Uttam Kulhari Naresh Kumar Upadhyayula Suryanarayana Murty Bidya Dhar Sahu Source Type: research
Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review
Mini Rev Med Chem. 2022 Feb 14. doi: 10.2174/1389557522666220214092005. Online ahead of print.ABSTRACTPlant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet n...
Source: Mini Reviews in Medicinal Chemistry - February 14, 2022 Category: Chemistry Authors: Ankush Kumar Jha Shobhit Gairola Sourav Kundu Pakpi Doye Abu Mohammad Syed Chetan Ram Uttam Kulhari Naresh Kumar Upadhyayula Suryanarayana Murty Bidya Dhar Sahu Source Type: research
Micronized cellulose from citrus processing waste using water and electricity only
Int J Biol Macromol. 2022 Feb 11:S0141-8130(22)00278-1. doi: 10.1016/j.ijbiomac.2022.02.042. Online ahead of print.ABSTRACTAlong with a water-soluble fraction rich in pectin, the hydrodynamic cavitation of citrus processing waste carried out in water demonstrated directly on semi-industrial scale affords an insoluble fraction consisting of micronized cellulose of low crystallinity ("CytroCell"). Lemon and grapefruit CytroCell respectively consist of 100-500 nm wide cellulose nanorods, and of 500-1000 nm wide ramified microfibrils extending for several μm. These findings establish a technically viable route to low crystall...
Source: International Journal of Biological Macromolecules - February 14, 2022 Category: Biochemistry Authors: Samar Al Jitan Antonino Scurria Lorenzo Albanese Mario Pagliaro Francesco Meneguzzo Federica Zabini Reem Al Sakkaf Ahmed Yusuf Giovanni Palmisano Rosaria Ciriminna Source Type: research
Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent
Environ Sci Pollut Res Int. 2022 Feb 4. doi: 10.1007/s11356-022-18754-6. Online ahead of print.ABSTRACTThough the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are examples of traditional cancer treatment approaches. However, multiple short- and long-term adverse effects may also significantly affect patient prognosis depending on treatment...
Source: Cell Research - February 4, 2022 Category: Cytology Authors: Abdur Rauf Mohammad Ali Shariati Muhammad Imran Kashif Bashir Shahid Ali Khan Saikat Mitra Talha Bin Emran Kamala Badalova Md Sahab Uddin Mohammad S Mubarak Abdullah S M Aljohani Fahad A Alhumaydhi Marina Derkho Serdar Korpayev Gokhan Zengin Source Type: research
Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent
Environ Sci Pollut Res Int. 2022 Feb 4. doi: 10.1007/s11356-022-18754-6. Online ahead of print.ABSTRACTThough the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are examples of traditional cancer treatment approaches. However, multiple short- and long-term adverse effects may also significantly affect patient prognosis depending on treatment...
Source: Environmental Science and Pollution Research International - February 4, 2022 Category: Environmental Health Authors: Abdur Rauf Mohammad Ali Shariati Muhammad Imran Kashif Bashir Shahid Ali Khan Saikat Mitra Talha Bin Emran Kamala Badalova Md Sahab Uddin Mohammad S Mubarak Abdullah S M Aljohani Fahad A Alhumaydhi Marina Derkho Serdar Korpayev Gokhan Zengin Source Type: research
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus & #935; paradisi: A comprehensive review for maximizing its value
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - February 4, 2022 Category: Nutrition Authors: Khalil, Mohammed N. A. Farghal, Hebatullah H. Farag, Mohamed A. Source Type: research
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype CYP3A5*3/*3: a case report
J Toxicol Sci. 2022;47(2):71-75. doi: 10.2131/jts.47.71.ABSTRACTThis case involved a 27-year-old man with extreme obesity (body mass index 45.6 kg/m2) who had a history of fulminant hepatitis and living-donor liver transplantation at 11 years of age. He had been receiving oral sustained-release tacrolimus (TAC) 1.5 mg daily, and the trough concentration in the blood was below 2.0 ng/mL. He has an intrinsic cytochrome P450 3A5 (CYP3A5)*3/*3 (G/G) genotype and graft liver with CYP3A5*3 allele donated by his biological father. Additionally, there were no data on the phenotype of P-glycoprotein. He did not take medications, gr...
Source: Journal of Toxicological Sciences - February 3, 2022 Category: Toxicology Authors: Toshinori Hirai Yoshihiko Morikawa Noriko Sasaki Hideo Kato Daisuke Nakato Masahiro Hirayama Tadashi Kaneko Hiroshi Imai Takuya Iwamoto Source Type: research
