Interfering grapefruit and low-stress tomatoes
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - January 31, 2022 Category: Chemistry Authors: Brianna Barbu Source Type: research
A Plea for Accuracy
Inaccuracy of description is a common sin in medical literature. Some articles give the reader the impression that the author has not been informed that there exist standard systems of weights and measures. We are told that a nodule the size of a chestnut was present in the abdominal wall, or that an ulcer the size of a dime was located on the forearm. These descriptions may mean something to the writer who saw the objects, but they carry much less information than they should to the reader. Too many writers seem to forget that medical literature is international, and that their reports, if of any value, will be read in al...
Source: JAMA - January 11, 2022 Category: General Medicine Source Type: research
Diaphorina citri flavi-like virus localization, transmission, and association with Candidatus Liberibacter asiaticus in its psyllid host
Virology. 2021 Dec 27;567:47-56. doi: 10.1016/j.virol.2021.12.009. Online ahead of print.ABSTRACTHuanglongbing is caused by Candidatus Liberibacter asiaticus (CLas) and transmitted by Diaphorina citri. D. citri harbors various insect-specific viruses, including the Diaphorina citri flavi-like virus (DcFLV). The distribution and biological role of DcFLV in its host and the relationship with CLas are unknown. DcFLV was found in various organs of D. citri, including the midgut and salivary glands, where it co-localized with CLas. CLas-infected nymphs had the highest DcFLV titers compared to the infected adults and CLas-free a...
Source: Virology - January 8, 2022 Category: Virology Authors: Mahnaz Rashidi Chun-Yi Lin Kellee Britt Ozgur Batuman Maher Al Rwahnih Diann Achor Amit Levy Source Type: research
Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity
This study aimed to investigate the inhibitory effects of two GFJ ingredients, bergamottin (BG) and dihydroxybergamottin (DHB), and resveratrol on CYP2C9 activity in vitro. DHB inhibited CYP2C9 activity, as assessed by warfarin 7-hydroxylation, in a preincubation time-dependent manner (i.e., mechanism-based inhibition; MBI), in the same manner as CYP2C19 and CYP3A4. The maximal inactivation rate (kinact,max) was 0.0638 min-1 and 0.12- and 0.26-fold of that for CYP2C19 and CYP3A4, respectively. BG showed both MBI and time-independent competitive inhibition. Resveratrol showed non-competitive inhibition with an inhibition co...
Source: Drug Metabolism and Pharmacokinetics - January 3, 2022 Category: Drugs & Pharmacology Authors: Takeshi Akiyoshi Marika Uchiyama Rino Inada Ayuko Imaoka Hisakazu Ohtani Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Cell Research)
Source: Cell Research - December 25, 2021 Category: Cytology Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 25, 2021 Category: Drugs & Pharmacology Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomed Res)
Source: Biomed Res - December 25, 2021 Category: Research Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 25, 2021 Category: Drugs & Pharmacology Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomed Res)
Source: Biomed Res - December 25, 2021 Category: Research Authors: R Dhanya Source Type: research
Spontaneous retrobulbar hemorrhage in the setting of warfarin therapy and latent scurvy diagnosis
We present a case of spontaneous nontraumatic retrobulbar hemorrhage associated with anti-coagulation therapy and a new diagnosis of scurvy. A 68-year-old male on chronic anti-coagulation therapy presented with a retrobulbar hemorrhage requiring urgent canthotomy and cantholysis. Despite the absence of a supratherapeutic INR and normal clotting factors, the patient continued to have spontaneous hemorrhages within the orbit and elsewhere. Workup revealed a severe vitamin C deficiency consistent with scurvy. Further investigation of dietary history demonstrated an avoidance of all citrus fruit upon starting warfarin due to m...
Source: Orbit - December 16, 2021 Category: Opthalmology Authors: Brian W Chou Quinn N Rivera Courtney E Francis Source Type: research
Spontaneous retrobulbar hemorrhage in the setting of warfarin therapy and latent scurvy diagnosis
We present a case of spontaneous nontraumatic retrobulbar hemorrhage associated with anti-coagulation therapy and a new diagnosis of scurvy. A 68-year-old male on chronic anti-coagulation therapy presented with a retrobulbar hemorrhage requiring urgent canthotomy and cantholysis. Despite the absence of a supratherapeutic INR and normal clotting factors, the patient continued to have spontaneous hemorrhages within the orbit and elsewhere. Workup revealed a severe vitamin C deficiency consistent with scurvy. Further investigation of dietary history demonstrated an avoidance of all citrus fruit upon starting warfarin due to m...
Source: Orbit - December 16, 2021 Category: Opthalmology Authors: Brian W Chou Quinn N Rivera Courtney E Francis Source Type: research
Spontaneous retrobulbar hemorrhage in the setting of warfarin therapy and latent scurvy diagnosis
We present a case of spontaneous nontraumatic retrobulbar hemorrhage associated with anti-coagulation therapy and a new diagnosis of scurvy. A 68-year-old male on chronic anti-coagulation therapy presented with a retrobulbar hemorrhage requiring urgent canthotomy and cantholysis. Despite the absence of a supratherapeutic INR and normal clotting factors, the patient continued to have spontaneous hemorrhages within the orbit and elsewhere. Workup revealed a severe vitamin C deficiency consistent with scurvy. Further investigation of dietary history demonstrated an avoidance of all citrus fruit upon starting warfarin due to m...
Source: Orbit - December 16, 2021 Category: Opthalmology Authors: Brian W Chou Quinn N Rivera Courtney E Francis Source Type: research
