Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis
by Opalina Vetrichelvan, Priyatham Gorjala, Oscar Goodman Jr., Ranjana Mitra
Prostate cancer is the second leading cause of cancer related death in American men. Several therapies have been developed to treat advanced prostate cancer, but these therapies often have severe side effects. To improve the outcome with fewer side effects we focused on the furanocoumarin bergamot tin, a natural product found in grapefruit juice and a potent CYP3A inhibitor. Our recent studies have shown that CYP3A5 inhibition can block androgen receptor (AR) signaling, critical for prostate cancer growth. We observed that bergamottin reduces pro...
Source: PLoS One - September 27, 2021 Category: Biomedical Science Authors: Opalina Vetrichelvan Source Type: research
Anticancer potential of Naringenin, Biosynthesis, Molecular target, and structural perspectives
Mini Rev Med Chem. 2021 Sep 12. doi: 10.2174/1389557521666210913112733. Online ahead of print.ABSTRACTNumerous novel medicinal agents isolated from plant sources were used as indigenous remedies for the management and treatment of various types of cancer diseases. Naringenin is a naturally occurring flavanone glycoside and aglycone (genin) moiety of naringin, predominantly found in citrus and grapefruits, has emerged as a potential therapeutic agent for the management of a variety of diseases. A huge number of scientific papers have been published on naringenin describing its detailed studies and its therapeutic applicatio...
Source: Mini Reviews in Medicinal Chemistry - September 14, 2021 Category: Chemistry Authors: Om Prakash Ruchi Singh Namrata Singh Shazia Usmani Mohd Arif Rajesh Kumar Akash Ved Source Type: research
Protocol of controlled odorant stimulation for reducing apnoeic episodes in premature newborns: a randomised open-label Latin-square study with independent evaluation of the main endpoint (PREMODEUR)
The objective of the present protocol is to reduce the occurrence of apnoeic episodes in premature newborns by controlled odorant stimulation added to current pharmacological treatments.
Methods and analysis
The project is a randomised open-label Latin-square trial with independent evaluation of the main endpoint. It will include 60 preterm neonates from two university hospital neonatal intensive care units over 2 years (2021–2023). Each newborn will receive no (S0), sham (S1) or real olfactory stimulation (S2) in random order. During S2, three distinct odorants (mint, grapefruit and vanilla) will be delivered succe...
Source: BMJ Open - September 13, 2021 Category: General Medicine Authors: Duchamp-Viret, P., Nguyen, H. K., Maucort-Boulch, D., Remontet, L., Guyon, A., Franco, P., Cividjian, A., Thevenet, M., Iwaz, J., Galletti, S., Kassai, B., Cornaton, E., Plaisant, F., Claris, O., Gauthier-Moulinier, H. Tags: Open access, Paediatrics Source Type: research
Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines
Nutr Cancer. 2021 Aug 25:1-8. doi: 10.1080/01635581.2021.1952438. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a grade IV, lethal, and the most common type of brain tumor. GBM can acquire resistance to temozolomide (TMZ) recommended for its treatment. Naringenin (NAG), a flavonoid generally found in grapefruit, has antioxidant, anti-proliferative, and anti-inflammatory properties. It has been reported that phytochemicals can reduce resistance and improve the efficacy of a chemo-resistant drug. The combinatorial effect of TMZ and NAG on cell proliferation was evaluated using 3-4,5-dimethylthiazol-2-yl-2,5-...
Source: Nutrition and Cancer - August 25, 2021 Category: Cancer & Oncology Authors: Megha Gautam Reema Gabrani Source Type: research
Enhancing safety and quality of shrimp by nanoparticles of sodium alginate-based edible coating containing grapefruit seed extract
In this study, a nanoparticle-based edible coating solution was prepared, containing alginate as a coating agent and grapefruit seed extract as an antibacterial agent to improve the safety and quality of shrimp during storage. Shrimp coated with this formulation were maintained at 4 °C for 8 days, and periodically analyzed for changes in sensory, chemical [total volatile basic nitrogen (TVB-N) and pH] and microbial parameters. The uncoated shrimp exceeded the microbiological limits at 7.87 log CFU/g on Day 4 of storage, whereas the nanoparticle-based coated shrimp did not exceed the limit by Day 8 of storage. In addition,...
Source: International Journal of Biological Macromolecules - August 22, 2021 Category: Biochemistry Authors: Ji Hye Baek So-Young Lee Se-Wook Oh Source Type: research
Enhancing safety and quality of shrimp by nanoparticles of sodium alginate-based edible coating containing grapefruit seed extract
In this study, a nanoparticle-based edible coating solution was prepared, containing alginate as a coating agent and grapefruit seed extract as an antibacterial agent to improve the safety and quality of shrimp during storage. Shrimp coated with this formulation were maintained at 4°C for 8 days, and periodically analyzed for changes in sensory, chemical [total volatile basic nitrogen (TVB-N) and pH] and microbial parameters. The uncoated shrimp exceeded the microbiological limits at 7.87 log CFU/g on Day 4 of storage, whereas the nanoparticle-based coated shrimp did not exceed the limit by Day 8 of storage. In addition, ...
Source: International Journal of Biological Macromolecules - August 22, 2021 Category: Biochemistry Authors: Ji Hye Baek So-Young Lee Se-Wook Oh Source Type: research
Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits
CONCLUSIONS: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.PMID:34387174 | DOI:10.2174/1871529X21666210812111931 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 13, 2021 Category: Drugs & Pharmacology Authors: Dinesh Kumar Patel Source Type: research
