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Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research

Preparation of Acetylated Grapefruit Peel Polysaccharide
Chem Biodivers. 2023 May 21:e202300167. doi: 10.1002/cbdv.202300167. Online ahead of print.ABSTRACTGrapefruit peel polysaccharide has antioxidant, antitumor, hypoglycemic and other biological activities, and chemical modification can further improve the properties of the polysaccharide. Acetylation modification of polysaccharides has the advantages of simple operation, low cost and little pollution, and is widely used at present. Different degrees of acetylation modification have different effects on the properties of polysaccharides, so it is necessary to optimize the preparation technology of acetylated grapefruit peel p...
Source: Chemistry and Biodiversity - May 22, 2023 Category: Biochemistry Authors: B B Yu Gangliang Huang Source Type: research

Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes
ConclusionThis framework would be a powerful tool for the reasonable management of various DIs based on all available in vitro and in vivo information. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - April 19, 2023 Category: Drugs & Pharmacology Source Type: research

Mediterranean diet and mitochondria: New findings
Exp Gerontol. 2023 Apr 3:112165. doi: 10.1016/j.exger.2023.112165. Online ahead of print.ABSTRACTMitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key role for mitochondria in the physiological response to both acute and chronic stress exposure, and, ultimately, the biological embedding of adversity in health and psychological functioning that increases the interest of these organelles in several medical conditions typical of older people. At the same time, Mediterranean diet (MedDiet) seems to affect the function of mitochondria further ju...
Source: Experimental Gerontology - April 5, 2023 Category: Geriatrics Authors: Francesco Pollicino Nicola Veronese Ligia J Dominguez Mario Barbagallo Source Type: research

Mediterranean diet and mitochondria: New findings
Exp Gerontol. 2023 Apr 5;176:112165. doi: 10.1016/j.exger.2023.112165. Online ahead of print.ABSTRACTMitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key role for mitochondria in the physiological response to both acute and chronic stress exposure, and, ultimately, the biological embedding of adversity in health and psychological functioning that increases the interest of these organelles in several medical conditions typical of older people. At the same time, Mediterranean diet (MedDiet) seems to affect the function of mitochondria furthe...
Source: Experimental Gerontology - April 5, 2023 Category: Geriatrics Authors: Francesco Pollicino Nicola Veronese Ligia J Dominguez Mario Barbagallo Source Type: research

[ASAP] Nanoencapsulation of Grapefruit Seed Extract and Cinnamon Oil for Oral Health: Preparation, In Vitro, and Clinical Antimicrobial Activities
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.2c05518 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - March 29, 2023 Category: Food Science Authors: Ye Seul Choi, Ji-Soo Lee, and Hyeon Gyu Lee Source Type: research

Molecules, Vol. 28, Pages 2904: Bioavailability of Bioactive Compounds from Reconstituted Grapefruit Juice as Affected by the Obtention Process
rrete Much attention has been paid to the health benefits of including fruits and vegetables in the diet. However, for the compounds responsible for this beneficial effect to be effective at the level of the human organism, they must be available for absorption after digestion. In this sense, in vivo studies are needed to demonstrate the bioavailability of these compounds and their physiological activity. In order to provide information in this regard, this study collects data on the levels of vitamin C (VC) and naringenin (NAG) in the blood serum of the 11 volunteer participants in this trial, before and after consumi...
Source: Molecules - March 23, 2023 Category: Chemistry Authors: Mar ía del Mar Camacho Juan Jos é Martínez-Lahuerta Eva Garc ía-Martínez Marta Igual Nuria Mart ínez-Navarrete Tags: Article Source Type: research