Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling
Mol Cell Biochem. 2021 Jun 15. doi: 10.1007/s11010-021-04193-3. Online ahead of print.ABSTRACTCitrus flavonoids particularly quercetin which is abundant in grapefruit, onion, green tea, berries etc. are known to have a protective effect on oxidative stress. Pancreatic β cells which synthesize and secrete insulin are prone to oxidative stress induced damage because of low cellular antioxidant enzymes. To delineate the effects of quercetin on pancreatic β cells we evaluated the protective effect of quercetin on TC6 insulinoma cells subjected to oxidative stress induced by tert-butyl-hydrogen-peroxide (TBHP). Quercetin was ...
Source: Molecular and Cellular Biochemistry - June 15, 2021 Category: Biochemistry Authors: R Dhanya C C Kartha Source Type: research
Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling
Mol Cell Biochem. 2021 Jun 15. doi: 10.1007/s11010-021-04193-3. Online ahead of print.ABSTRACTCitrus flavonoids particularly quercetin which is abundant in grapefruit, onion, green tea, berries etc. are known to have a protective effect on oxidative stress. Pancreatic β cells which synthesize and secrete insulin are prone to oxidative stress induced damage because of low cellular antioxidant enzymes. To delineate the effects of quercetin on pancreatic β cells we evaluated the protective effect of quercetin on TC6 insulinoma cells subjected to oxidative stress induced by tert-butyl-hydrogen-peroxide (TBHP). Quercetin was ...
Source: Molecular and Cellular Biochemistry - June 15, 2021 Category: Biochemistry Authors: R Dhanya C C Kartha Source Type: research
Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling
Mol Cell Biochem. 2021 Jun 15. doi: 10.1007/s11010-021-04193-3. Online ahead of print.ABSTRACTCitrus flavonoids particularly quercetin which is abundant in grapefruit, onion, green tea, berries etc. are known to have a protective effect on oxidative stress. Pancreatic β cells which synthesize and secrete insulin are prone to oxidative stress induced damage because of low cellular antioxidant enzymes. To delineate the effects of quercetin on pancreatic β cells we evaluated the protective effect of quercetin on TC6 insulinoma cells subjected to oxidative stress induced by tert-butyl-hydrogen-peroxide (TBHP). Quercetin was ...
Source: Molecular and Cellular Biochemistry - June 15, 2021 Category: Biochemistry Authors: R Dhanya C C Kartha Source Type: research
Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling
Mol Cell Biochem. 2021 Jun 15. doi: 10.1007/s11010-021-04193-3. Online ahead of print.ABSTRACTCitrus flavonoids particularly quercetin which is abundant in grapefruit, onion, green tea, berries etc. are known to have a protective effect on oxidative stress. Pancreatic β cells which synthesize and secrete insulin are prone to oxidative stress induced damage because of low cellular antioxidant enzymes. To delineate the effects of quercetin on pancreatic β cells we evaluated the protective effect of quercetin on TC6 insulinoma cells subjected to oxidative stress induced by tert-butyl-hydrogen-peroxide (TBHP). Quercetin was ...
Source: Molecular and Cellular Biochemistry - June 15, 2021 Category: Biochemistry Authors: R Dhanya C C Kartha Source Type: research
Molecules, Vol. 26, Pages 3387: Chemical Profiling, Toxicity and Anti-Inflammatory Activities of Essential Oils from Three Grapefruit Cultivars from KwaZulu-Natal in South Africa
a Oyedeji
The medicinal potential and volatile composition of different parts of three cultivars of grapefruit (Citrus paradisi) were evaluated for their toxicity and anti-inflammatory activities. Fresh leaf and fruit peel were separately isolated by hydrodistillation for 4 h. The essential oils were subjected to GC/GC-MS analysis for chemical profile. Toxicity of the essential oils in mice were evaluated using Lorke’s method, while an anti-inflammatory assay was performed in a rat model using egg albumin-induced oedema. The oils obtained were light yellow in colour, and odour varied from strong citrus smell to mild....
Source: Molecules - June 3, 2021 Category: Chemistry Authors: Gugulethu Miya Mongikazi Nyalambisa Opeoluwa Oyedeji Mavuto Gondwe Adebola Oyedeji Tags: Article Source Type: research
Stress-inducible Arabidopsis thaliana RD29A promoter constitutively drives Citrus sinensis APETALA1 and LEAFY expression and precocious flowering in transgenic Citrus spp
Transgenic Res. 2021 May 30. doi: 10.1007/s11248-021-00260-z. Online ahead of print.ABSTRACTTransgenic 'Duncan' grapefruit (Citrus paradisi Macf.) and 'Valencia' sweet orange (Citrus sinensis [L.] Osbeck) plants ectopically expressing C. sinensis (cv. Washington navel orange) APETALA1 (CsAP1) or LEAFY (CsLFY) genes under control of the Arabidopsis thaliana stress-inducible promoter AtRD29A flowered under non-inductive (warm temperature, well-watered) greenhouse conditions, whereas their wild-type (WT) counterparts did not. The transgenic plants that flowered exhibited no altered morphological features, except the lack of t...
Source: Transgenic Research - May 30, 2021 Category: Genetics & Stem Cells Authors: Vladimir Orbovi ć Seyed Ali Ravanfar Yosvanis Acanda Javier Narvaez Benjamin A Merritt Amit Levy Carol J Lovatt Source Type: research
Stress-inducible Arabidopsis thaliana RD29A promoter constitutively drives Citrus sinensis APETALA1 and LEAFY expression and precocious flowering in transgenic Citrus spp
Transgenic Res. 2021 May 30. doi: 10.1007/s11248-021-00260-z. Online ahead of print.ABSTRACTTransgenic 'Duncan' grapefruit (Citrus paradisi Macf.) and 'Valencia' sweet orange (Citrus sinensis [L.] Osbeck) plants ectopically expressing C. sinensis (cv. Washington navel orange) APETALA1 (CsAP1) or LEAFY (CsLFY) genes under control of the Arabidopsis thaliana stress-inducible promoter AtRD29A flowered under non-inductive (warm temperature, well-watered) greenhouse conditions, whereas their wild-type (WT) counterparts did not. The transgenic plants that flowered exhibited no altered morphological features, except the lack of t...
Source: Transgenic Research - May 30, 2021 Category: Genetics & Stem Cells Authors: Vladimir Orbovi ć Seyed Ali Ravanfar Yosvanis Acanda Javier Narvaez Benjamin A Merritt Amit Levy Carol J Lovatt Source Type: research
Stress-inducible Arabidopsis thaliana RD29A promoter constitutively drives Citrus sinensis APETALA1 and LEAFY expression and precocious flowering in transgenic Citrus spp
Transgenic Res. 2021 May 30. doi: 10.1007/s11248-021-00260-z. Online ahead of print.ABSTRACTTransgenic 'Duncan' grapefruit (Citrus paradisi Macf.) and 'Valencia' sweet orange (Citrus sinensis [L.] Osbeck) plants ectopically expressing C. sinensis (cv. Washington navel orange) APETALA1 (CsAP1) or LEAFY (CsLFY) genes under control of the Arabidopsis thaliana stress-inducible promoter AtRD29A flowered under non-inductive (warm temperature, well-watered) greenhouse conditions, whereas their wild-type (WT) counterparts did not. The transgenic plants that flowered exhibited no altered morphological features, except the lack of t...
Source: Transgenic Research - May 30, 2021 Category: Genetics & Stem Cells Authors: Vladimir Orbovi ć Seyed Ali Ravanfar Yosvanis Acanda Javier Narvaez Benjamin A Merritt Amit Levy Carol J Lovatt Source Type: research
Mechanistic study of bergamottin-induced inactivation of CYP2C9
In conclusion, BGM can be characterized as a mechanism-based inactivator of CYP2C9 acting via the formation of an epoxide and/or γ-ketoenal.PMID:34019943 | DOI:10.1016/j.fct.2021.112278 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 21, 2021 Category: Food Science Authors: Ying Liu Shiyu Zhang Tingting Jiang Rong Tan Yao Fu Xiaojing Yang Bowen Gong Ying Zou Weiwei Li Jiang Zheng Source Type: research
Mechanistic study of bergamottin-induced inactivation of CYP2C9
In conclusion, BGM can be characterized as a mechanism-based inactivator of CYP2C9 acting via the formation of an epoxide and/or γ-ketoenal.PMID:34019943 | DOI:10.1016/j.fct.2021.112278 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 21, 2021 Category: Food Science Authors: Ying Liu Shiyu Zhang Tingting Jiang Rong Tan Yao Fu Xiaojing Yang Bowen Gong Ying Zou Weiwei Li Jiang Zheng Source Type: research
Supercritical CO2 extraction of lycopene from pink grapefruit (Citrus paradise Macfad) and its degradation studies during storage
Publication date: Available online 16 May 2021Source: Food ChemistryAuthor(s): Jyoti Dhakane Lad, Abhijit Kar (Source: Food Chemistry)
Source: Food Chemistry - May 19, 2021 Category: Food Science Source Type: research
Pharmacological and therapeutic applications of Sinapic acid-an updated review
Mol Biol Rep. 2021 May 14. doi: 10.1007/s11033-021-06367-0. Online ahead of print.ABSTRACTPhenolic compounds, present in plants, are considered to be indispensable parts of human dietary sources. Sinapic acid, is a natural herbal compound containing phenolic acid. It is found in oranges, grapefruits, and cranberries and in herbs like canola, mustard seed and rapeseed. Sinapic acid is chemically studied as a cinnamic acid derivative that contains 3, 5-dimethoxyl and 4-hydroxyl substitutions in the phenyl group of cinnamic acid. Sinapic acid has been pharmacologically evaluated for its potent antioxidant, anti-inflammatory, ...
Source: Molecular Biology Reports - May 14, 2021 Category: Molecular Biology Authors: Anandakumar Pandi Vanitha Manickam Kalappan Source Type: research
Pharmacological and therapeutic applications of Sinapic acid-an updated review
Mol Biol Rep. 2021 May 14. doi: 10.1007/s11033-021-06367-0. Online ahead of print.ABSTRACTPhenolic compounds, present in plants, are considered to be indispensable parts of human dietary sources. Sinapic acid, is a natural herbal compound containing phenolic acid. It is found in oranges, grapefruits, and cranberries and in herbs like canola, mustard seed and rapeseed. Sinapic acid is chemically studied as a cinnamic acid derivative that contains 3, 5-dimethoxyl and 4-hydroxyl substitutions in the phenyl group of cinnamic acid. Sinapic acid has been pharmacologically evaluated for its potent antioxidant, anti-inflammatory, ...
Source: Molecular Biology Reports - May 14, 2021 Category: Molecular Biology Authors: Anandakumar Pandi Vanitha Manickam Kalappan Source Type: research
Pharmacological and therapeutic applications of Sinapic acid-an updated review
Mol Biol Rep. 2021 May 14. doi: 10.1007/s11033-021-06367-0. Online ahead of print.ABSTRACTPhenolic compounds, present in plants, are considered to be indispensable parts of human dietary sources. Sinapic acid, is a natural herbal compound containing phenolic acid. It is found in oranges, grapefruits, and cranberries and in herbs like canola, mustard seed and rapeseed. Sinapic acid is chemically studied as a cinnamic acid derivative that contains 3, 5-dimethoxyl and 4-hydroxyl substitutions in the phenyl group of cinnamic acid. Sinapic acid has been pharmacologically evaluated for its potent antioxidant, anti-inflammatory, ...
Source: Molecular Biology Reports - May 14, 2021 Category: Molecular Biology Authors: Anandakumar Pandi Vanitha Manickam Kalappan Source Type: research
Health beneficial and pharmacological properties of p-cymene
Food Chem Toxicol. 2021 May 10:112259. doi: 10.1016/j.fct.2021.112259. Online ahead of print.ABSTRACTp-cymene also known as p-cymol or p-isopropyltoluene is an alkyl-substituted aromatic compound naturally occurring in essential oils (EOs) of various aromatic plants, including the genus of Artemisia, Protium, Origanum, and Thymus. It is related to the family of terpenes, especially monocyclic monoterpenes. p-cymene is also present in several food-based plants such as carrots, orange juice, grapefruit, tangerine, raspberries and several spices. Numerous studies have demonstrated the pharmacological properties of the monoter...
Source: Food and Chemical Toxicology - May 13, 2021 Category: Food Science Authors: Abdelaali Balahbib Nasreddine El Omari Naoufal El Hachlafi Fatima Lakhdar Naoual El Menyiy Najoua Salhi Hanae Naceiri Mrabti Saad Bakrim Gokhan Zengin Abdelhakim Bouyahya Source Type: research
