Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition
In this study, monocrotaline (MCT) administration (60 mg/kg) was delivered for the induction of PAH in rats. Following this, Naringin (concentrations: 25, 50, and 100 mg/kg/day) was used for treatments. Human Umbilical Vein Endothelial Cells (HUVECs) were stimulated with Naringin and transforming growth factor β1 (TGFβ1, 10 ng/ml). As the result, Naringin was demonstrated to inhibit EndMT and alleviate PAH progression. In particular, in HUVECs, Naringin significantly suppressed the mesenchymal marker expression induced by TGFβ1 treatment, enhanced the endothelial marker expression, and inhibited the activation of ERK...
Source: Frontiers in Pharmacology - July 15, 2021 Category: Drugs & Pharmacology Source Type: research
A narrative review of the importance of pharmacokinetics and drug-drug interactions of preventive therapies in migraine management
CONCLUSIONS: DDIs are important to consider in patients with migraine who use multiple medications. The development of migraine-specific evidence-based preventive treatments allows for tailored clinical management that reduces the risk of DDIs and associated AEs in patients with comorbidities.PMID:34214182 | DOI:10.1111/head.14135 (Source: Headache)
Source: Headache - July 2, 2021 Category: Neurology Authors: Shivang Joshi Stewart J Tepper Sylvia Lucas Soeren Rasmussen Rob Nelson Source Type: research
A narrative review of the importance of pharmacokinetics and drug-drug interactions of preventive therapies in migraine management
CONCLUSIONS: DDIs are important to consider in patients with migraine who use multiple medications. The development of migraine-specific evidence-based preventive treatments allows for tailored clinical management that reduces the risk of DDIs and associated AEs in patients with comorbidities.PMID:34214182 | DOI:10.1111/head.14135 (Source: Headache)
Source: Headache - July 2, 2021 Category: Neurology Authors: Shivang Joshi Stewart J Tepper Sylvia Lucas Soeren Rasmussen Rob Nelson Source Type: research
Investigation of the impact of grapefruit juice, pomegranate juice and tomato juice on pharmacokinetics of brexpiprazole in rats using UHPLC-QTOF-MS
Biomed Chromatogr. 2021 Jun 18:e5201. doi: 10.1002/bmc.5201. Online ahead of print.ABSTRACTBrexpiprazole (BRX) is approved for the treatment of schizophrenia and major depressive disorders and it is mainly metabolized by CYP3A4 and CYP2D6. Grapefruit juice (GFJ), pomegranate juice (PJ) and tomato juice (TJ) have the potential to inhibit CYP3A4 enzymes in the body. However, fruit juice-drug interactions between BRX and GFJ, PJ and TJ are not studied extensively. The present study describes the influence of GFJ, PJ and TJ on the pharmacokinetic parameters of BRX in rats. The study samples were analyzed using a mass accurate ...
Source: Biomedical Chromatography : BMC - June 20, 2021 Category: Biomedical Science Authors: Disha Thakkar Amit Kumar Sahu Rajeshwari Rathod Pinaki Sengupta Abhijeet S Kate Source Type: research
Investigation of the impact of grapefruit juice, pomegranate juice and tomato juice on pharmacokinetics of brexpiprazole in rats using UHPLC-QTOF-MS
Biomed Chromatogr. 2021 Jun 18:e5201. doi: 10.1002/bmc.5201. Online ahead of print.ABSTRACTBrexpiprazole (BRX) is approved for the treatment of schizophrenia and major depressive disorders and it is mainly metabolized by CYP3A4 and CYP2D6. Grapefruit juice (GFJ), pomegranate juice (PJ) and tomato juice (TJ) have the potential to inhibit CYP3A4 enzymes in the body. However, fruit juice-drug interactions between BRX and GFJ, PJ and TJ are not studied extensively. The present study describes the influence of GFJ, PJ and TJ on the pharmacokinetic parameters of BRX in rats. The study samples were analyzed using a mass accurate ...
Source: Biomedical Chromatography : BMC - June 20, 2021 Category: Biomedical Science Authors: Disha Thakkar Amit Kumar Sahu Rajeshwari Rathod Pinaki Sengupta Abhijeet S Kate Source Type: research
Using essential oils from Citrus paradisi as a fumigant for Solenopsis invicta workers and evaluating the oils' effect on worker behavior
In this study, grapefruit essential oils were used as fumigant agents to control red imported fire ants. The crude grapefruit oil (GO1) contained 28 compounds, and the concentrated grapefruit oil (GO2), which was refined from GO1 by vacuum distillation, contained 20 compounds. D-Limonene was the dominant constituent in both GO1 (70.1%) and GO2 (73.96%), and other important constituents included β-pinene, α-pinene, β-phellandrene, octanal, d-carvone, α-terpineol, and linalool. Both the essential oils and their individual constituents (α-pinene, α-terpineol, β-phellandrene, octanal, and d-carvone) showed strong lethal...
Source: Environmental Science and Pollution Research International - June 18, 2021 Category: Environmental Health Authors: Ning Zhang Yihong Liao Lianjie Xie Zhixiang Zhang Wei Hu Source Type: research
Using essential oils from Citrus paradisi as a fumigant for Solenopsis invicta workers and evaluating the oils' effect on worker behavior
In this study, grapefruit essential oils were used as fumigant agents to control red imported fire ants. The crude grapefruit oil (GO1) contained 28 compounds, and the concentrated grapefruit oil (GO2), which was refined from GO1 by vacuum distillation, contained 20 compounds. D-Limonene was the dominant constituent in both GO1 (70.1%) and GO2 (73.96%), and other important constituents included β-pinene, α-pinene, β-phellandrene, octanal, d-carvone, α-terpineol, and linalool. Both the essential oils and their individual constituents (α-pinene, α-terpineol, β-phellandrene, octanal, and d-carvone) showed strong lethal...
Source: Environmental Science and Pollution Research International - June 18, 2021 Category: Environmental Health Authors: Ning Zhang Yihong Liao Lianjie Xie Zhixiang Zhang Wei Hu Source Type: research
Combined microwave and enzymatic treatment improve the release of insoluble bound phenolic compounds from the grapefruit peel insoluble dietary fiber
Publication date: September 2021Source: LWT, Volume 149Author(s): Guanyi Peng, Jiapan Gan, Ruihong Dong, Yi Chen, Jianhua Xie, Ziyan Huang, Yue Gu, Danfei Huang, Qiang Yu (Source: LWT Food Science and Technology)
Source: LWT Food Science and Technology - June 16, 2021 Category: Food Science Source Type: research
