Effects of ultrasound time, xanthan gum, and sucrose levels on the osmosis dehydration and appearance characteristics of grapefruit slices: Process optimization using response surface methodology
Ultrason Sonochem. 2023 Jul 8;98:106505. doi: 10.1016/j.ultsonch.2023.106505. Online ahead of print.ABSTRACTIn this work, the novel use of ultrasonic pre-treatment and edible coating treatment during osmosis dehydration to optimize the weight reduction, moisture loss, sucrose gain, rehydration, and surface shrinkage using a response surface methodology (RSM) based on a central composite design (CCD) technique was successfully conducted on grapefruit slices. The process parameters include sonication pre-treatment time (5-10 min), xanthan-gum-based edible coating (0.1%-0.3%, w/w), and sucrose concentration (20-50 Brix), were...
Source: Ultrasonics Sonochemistry - July 12, 2023 Category: Chemistry Authors: Fakhreddin Salehi Helia Razavi Kamran Kimia Goharpour Source Type: research
Physiologically based pharmacokinetic modeling of bergamottin and 6,7-dihydroxybergamottin to describe CYP3A4 mediated grapefruit-drug interactions
Clin Pharmacol Ther. 2023 Jun 12. doi: 10.1002/cpt.2968. Online ahead of print.ABSTRACTGrapefruit is a moderate to strong inactivator of CYP3A4, which metabolizes up to 50% of marketed drugs. The inhibitory effect is mainly attributed to furanocoumarins present in the fruit, irreversibly inhibiting preferably intestinal CYP3A4 as suicide inhibitors. Effects on CYP3A4 victim drugs can still be measured up to 24 h after grapefruit juice consumption. The current study aimed to establish a PBPK grapefruit-drug interaction model by modeling the relevant CYP3A4 inhibiting ingredients of the fruit to simulate and predict the effe...
Source: Clinical Pharmacology and Therapeutics - June 12, 2023 Category: Drugs & Pharmacology Authors: Laura Maria Fuhr Fatima Zahra Marok Uwe Fuhr Dominik Selzer Thorsten Lehr Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence
Chem Pharm Bull (Tokyo). 2023;71(6):441-446. doi: 10.1248/cpb.c23-00102.ABSTRACTGood adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-...
Source: Chemical and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Sayuri Kawamoto Shimako Tanaka Motoyasu Miura Yasuharu Kashiwagura Chiaki Kamiya Akio Hakamata Keiichi Odagiri Naoki Inui Hiroshi Watanabe Noriyuki Namiki Shinya Uchida Source Type: research
