Lithium-loaded GelMA-Phosphate glass fibre constructs: Implications for astrocyte response
This study was also aimed at investigating the effects of lithium-loaded GelMA-PGFs hydrogels in alleviating astrocyte reactivity and glial scar formation offering novel perspectives for neural tissue engineering applications. The rationale behind introducing lithium is driven by its long-proven therapeutic benefits in mental disorders, and neuroprotective and pronounced anti-inflammatory properties. The optimal concentrations of lithium and LPS were determined in vitro on primary rat astrocytes. Furthermore, qPCR was conducted for gene expression analysis of GFAP and IL-6 markers on primary astrocytes cultured 3D into Gel...
Source: Cell Research - February 24, 2024 Category: Cytology Authors: Zalike Keskin-Erdogan Nandin Mandakhbayar Gang Shi Jin Yu-Meng Li David Y S Chau Richard M Day Hae-Won Kim Jonathan C Knowles Source Type: research
The corticospinal system and ALS
Clin Neurophysiol. 2024 Feb 9;160:56-67. doi: 10.1016/j.clinph.2024.02.001. Online ahead of print.ABSTRACTCorticospinal neurons located in motor areas of the cerebral neocortex project corticospinal axons which synapse with the spinal network; a parallel corticobulbar system projects to the cranial motor network and to brainstem motor pathways. The primate corticospinal system has a widespread cortical origin and an extensive range of different fibre diameters, including thick, fast-conducting axons. Direct cortico-motoneuronal (CM) projections from the motor cortex to arm and hand alpha motoneurons are a recent evolutiona...
Source: Clinical Neurophysiology - February 24, 2024 Category: Neurology Authors: Roger Lemon Source Type: research
Lithium-loaded GelMA-Phosphate glass fibre constructs: Implications for astrocyte response
This study was also aimed at investigating the effects of lithium-loaded GelMA-PGFs hydrogels in alleviating astrocyte reactivity and glial scar formation offering novel perspectives for neural tissue engineering applications. The rationale behind introducing lithium is driven by its long-proven therapeutic benefits in mental disorders, and neuroprotective and pronounced anti-inflammatory properties. The optimal concentrations of lithium and LPS were determined in vitro on primary rat astrocytes. Furthermore, qPCR was conducted for gene expression analysis of GFAP and IL-6 markers on primary astrocytes cultured 3D into Gel...
Source: Biomed Res - February 24, 2024 Category: Research Authors: Zalike Keskin-Erdogan Nandin Mandakhbayar Gang Shi Jin Yu-Meng Li David Y S Chau Richard M Day Hae-Won Kim Jonathan C Knowles Source Type: research
The corticospinal system and ALS
Clin Neurophysiol. 2024 Feb 9;160:56-67. doi: 10.1016/j.clinph.2024.02.001. Online ahead of print.ABSTRACTCorticospinal neurons located in motor areas of the cerebral neocortex project corticospinal axons which synapse with the spinal network; a parallel corticobulbar system projects to the cranial motor network and to brainstem motor pathways. The primate corticospinal system has a widespread cortical origin and an extensive range of different fibre diameters, including thick, fast-conducting axons. Direct cortico-motoneuronal (CM) projections from the motor cortex to arm and hand alpha motoneurons are a recent evolutiona...
Source: Clinical Neurophysiology - February 24, 2024 Category: Neurology Authors: Roger Lemon Source Type: research
The corticospinal system and ALS
Clin Neurophysiol. 2024 Feb 9;160:56-67. doi: 10.1016/j.clinph.2024.02.001. Online ahead of print.ABSTRACTCorticospinal neurons located in motor areas of the cerebral neocortex project corticospinal axons which synapse with the spinal network; a parallel corticobulbar system projects to the cranial motor network and to brainstem motor pathways. The primate corticospinal system has a widespread cortical origin and an extensive range of different fibre diameters, including thick, fast-conducting axons. Direct cortico-motoneuronal (CM) projections from the motor cortex to arm and hand alpha motoneurons are a recent evolutiona...
Source: Clinical Neurophysiology - February 24, 2024 Category: Neurology Authors: Roger Lemon Source Type: research
Corneal stress‒strain index in relation to retinal nerve fibre layer thickness among healthy young adults
Eye, Published online: 24 February 2024; doi:10.1038/s41433-024-02985-7Corneal stress‒strain index in relation to retinal nerve fibre layer thickness among healthy young adults (Source: Eye)
Source: Eye - February 24, 2024 Category: Opthalmology Authors: Min-Xin Liu Dan-Lin Li Zhi-Jian Yin Yue-Zu Li Ya-Jie Zheng Yu Qin Rong Ma Gang Liang Chen-Wei Pan Source Type: research
A combined analytical and Monte Carlo method for detailed simulations of antiscatter grids in x-ray medical imaging: implementing scatter within the grid
Phys Med Biol. 2024 Feb 21. doi: 10.1088/1361-6560/ad2b93. Online ahead of print.ABSTRACTTo implement a hybrid method, which combines analytical tracking and interaction simulation using Monte Carlo (MC) techniques, in order to model photon transport inside antiscatter grids (ASG) for x-ray imaging.
Approach: A new tally was developed for PENELOPE (v.2018) and penEasy (v. 2020) MC code to simulate photon transmission through ASGs. Two established analytical algorithms from the literature were implemented in this tally. In addition, new hybrid method was introduced by extending one of the analytical algorithms to in...
Source: Physics in Medicine and Biology - February 21, 2024 Category: Physics Authors: Rodrigo Trevisan Massera Hilde Bosmans Sunay Rodriguez Perez Nicholas W Marshall Source Type: research
Quantitation of circulating short-chain fatty acids in small volume blood samples from animals and humans
Talanta. 2024 Feb 3;272:125743. doi: 10.1016/j.talanta.2024.125743. Online ahead of print.ABSTRACTBACKGROUND: The role of gut microbiota in human health has been intensively studied and more recently shifted from emphasis on composition towards function. Function is partly mediated through formed metabolites. Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate as well as their branched analogues represent major products from gut fermentation of dietary fibre and proteins, respectively. Robust and high-throughput analysis of SCFAs in small volume blood samples have proven difficult. Major obstacles com...
Source: Talanta - February 21, 2024 Category: Chemistry Authors: Rikard Fristedt Vanessa Ruppert Tania Trower Janine Cooney Rikard Landberg Source Type: research
A combined analytical and Monte Carlo method for detailed simulations of antiscatter grids in x-ray medical imaging: implementing scatter within the grid
Phys Med Biol. 2024 Feb 21. doi: 10.1088/1361-6560/ad2b93. Online ahead of print.ABSTRACTTo implement a hybrid method, which combines analytical tracking and interaction simulation using Monte Carlo (MC) techniques, in order to model photon transport inside antiscatter grids (ASG) for x-ray imaging.
Approach: A new tally was developed for PENELOPE (v.2018) and penEasy (v. 2020) MC code to simulate photon transmission through ASGs. Two established analytical algorithms from the literature were implemented in this tally. In addition, new hybrid method was introduced by extending one of the analytical algorithms to in...
Source: Physics in Medicine and Biology - February 21, 2024 Category: Physics Authors: Rodrigo Trevisan Massera Hilde Bosmans Sunay Rodriguez Perez Nicholas W Marshall Source Type: research
Influence of choroidal microvasculature dropout on progressive retinal nerve fibre layer thinning in primary open-angle glaucoma: comparison of parapapillary {beta}-zones and {gamma}-zones
Conclusions
The presence of cMvD was significantly associated with a faster rate of RNFL thinning in POAG eyes with β-zone, but not -zone. The pathogenic consequences of cMvD in POAG eyes may depend on accompanying peripapillary structures. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Hwang, H. S., Lee, E. J., Kim, J.-A., Lee, S. H., Kim, T.-W. Tags: Glaucoma Source Type: research
Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation
CONCLUSIONS: We conclude that this approach to peptide discovery and testing can identify new synthetic matrikines, providing insights into biological mechanisms of tissue homeostasis and repair and new pathways to clinical intervention.PMID:38375775 | DOI:10.1093/bjd/ljae061 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2024 Category: Dermatology Authors: Nathan Jariwala Matiss Ozols Alexander Eckersley Bezaleel Mambwe Rachel E B Watson Leo Zeef Andrew Gilmore Laurent Debelle Mike Bell Eleanor J Bradley Yegor Doush Amy Keenan Carole Courage Richard Leroux Olivier Peschard Philippe Mondon Caroline Ringenbac Source Type: research
Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis
CONCLUSIONS: These progressive changes seen across the disease spectrum in ATTRv-PN suggest that axonal excitability has utility to identify early and progressive nerve dysfunction in ATTRv, regardless of genotype.SIGNIFICANCE: Axonal excitability is a promising early biomarker of nerve dysfunction in ATTRv-PN.PMID:38377648 | DOI:10.1016/j.clinph.2024.01.006 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - February 20, 2024 Category: Neurology Authors: Antonia S Carroll Susanna B Park Cindy S Y Lin Mark S Taylor Fiona Kwok Neil G Simon Mary M Reilly Matthew C Kiernan Steve Vucic Source Type: research
Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation
CONCLUSIONS: We conclude that this approach to peptide discovery and testing can identify new synthetic matrikines, providing insights into biological mechanisms of tissue homeostasis and repair and new pathways to clinical intervention.PMID:38375775 | DOI:10.1093/bjd/ljae061 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2024 Category: Dermatology Authors: Nathan Jariwala Matiss Ozols Alexander Eckersley Bezaleel Mambwe Rachel E B Watson Leo Zeef Andrew Gilmore Laurent Debelle Mike Bell Eleanor J Bradley Yegor Doush Amy Keenan Carole Courage Richard Leroux Olivier Peschard Philippe Mondon Caroline Ringenbac Source Type: research
Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis
CONCLUSIONS: These progressive changes seen across the disease spectrum in ATTRv-PN suggest that axonal excitability has utility to identify early and progressive nerve dysfunction in ATTRv, regardless of genotype.SIGNIFICANCE: Axonal excitability is a promising early biomarker of nerve dysfunction in ATTRv-PN.PMID:38377648 | DOI:10.1016/j.clinph.2024.01.006 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - February 20, 2024 Category: Neurology Authors: Antonia S Carroll Susanna B Park Cindy S Y Lin Mark S Taylor Fiona Kwok Neil G Simon Mary M Reilly Matthew C Kiernan Steve Vucic Source Type: research
Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis
CONCLUSIONS: These progressive changes seen across the disease spectrum in ATTRv-PN suggest that axonal excitability has utility to identify early and progressive nerve dysfunction in ATTRv, regardless of genotype.SIGNIFICANCE: Axonal excitability is a promising early biomarker of nerve dysfunction in ATTRv-PN.PMID:38377648 | DOI:10.1016/j.clinph.2024.01.006 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - February 20, 2024 Category: Neurology Authors: Antonia S Carroll Susanna B Park Cindy S Y Lin Mark S Taylor Fiona Kwok Neil G Simon Mary M Reilly Matthew C Kiernan Steve Vucic Source Type: research
