A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 21:167131. doi: 10.1016/j.bbadis.2024.167131. Online ahead of print.ABSTRACTMitochondrial DNA (mtDNA) deletions which clonally expand in skeletal muscle of patients with mtDNA maintenance disorders, impair mitochondrial oxidative phosphorylation dysfunction. Previously we have shown that these mtDNA deletions arise and accumulate in perinuclear mitochondria causing localised mitochondrial dysfunction before spreading through the muscle fibre. We believe that mito-nuclear signalling is a key contributor in the accumulation and spread of mtDNA deletions, and that knowledge of how ...
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Amy E Vincent Chun Chen Tiago Bernardino Gomes Valeria Di Leo Tuomas Laalo Kamil Pabis Rodrick Capaldi Michael F Marusich David McDonald Andrew Filby Andrew Fuller Diana Lehmann Urban Stephan Zierz Marcus Deschauer Doug Turnbull Amy K Reeve Conor Lawless Source Type: research
A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 21:167131. doi: 10.1016/j.bbadis.2024.167131. Online ahead of print.ABSTRACTMitochondrial DNA (mtDNA) deletions which clonally expand in skeletal muscle of patients with mtDNA maintenance disorders, impair mitochondrial oxidative phosphorylation dysfunction. Previously we have shown that these mtDNA deletions arise and accumulate in perinuclear mitochondria causing localised mitochondrial dysfunction before spreading through the muscle fibre. We believe that mito-nuclear signalling is a key contributor in the accumulation and spread of mtDNA deletions, and that knowledge of how ...
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Amy E Vincent Chun Chen Tiago Bernardino Gomes Valeria Di Leo Tuomas Laalo Kamil Pabis Rodrick Capaldi Michael F Marusich David McDonald Andrew Filby Andrew Fuller Diana Lehmann Urban Stephan Zierz Marcus Deschauer Doug Turnbull Amy K Reeve Conor Lawless Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
In vitro protein digestion and carbohydrate colon fermentation of microbial biomass samples from bacterial, filamentous fungus and yeast sources
This study evaluated the nutritional quality of different microbial biomass samples by assessing their protein digestibility and carbohydrate fermentability in the colon using in vitro methods. Four microbial samples were produced: one hydrogen-oxidizing bacterial strain (Nocardioides nitrophenolicus KGS-27), two strains of filamentous fungi (Rhizopus oligosporus and Paecilomyces variotii), and one yeast strain (Rhodotorula babjevae). The microorganisms were grown in bioreactors, harvested and dried before analysis. The commercial fungal product Quorn was used as a reference. The protein digestibility of the microbial samp...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Nordlund Emilia Silventoinen-Veijalainen Pia Hyyti äinen-Pabst Tiina Nyyss ölä Antti Valtonen Anniina Ritala Anneli Lienemann Michael Rosa-Sibakov Natalia Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
Effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture on anterior dentition defects with minimal vertical intermaxillary space
CONCLUSION: Orthodontics combined with FRC-RBFPD shows an ideal restorative effect on patients with anterior dentition defects and minimal vertical intermaxillary space.PMID:38517820 | DOI:10.3233/THC-231889 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Shi-Lei Han Na Li Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
In vitro protein digestion and carbohydrate colon fermentation of microbial biomass samples from bacterial, filamentous fungus and yeast sources
This study evaluated the nutritional quality of different microbial biomass samples by assessing their protein digestibility and carbohydrate fermentability in the colon using in vitro methods. Four microbial samples were produced: one hydrogen-oxidizing bacterial strain (Nocardioides nitrophenolicus KGS-27), two strains of filamentous fungi (Rhizopus oligosporus and Paecilomyces variotii), and one yeast strain (Rhodotorula babjevae). The microorganisms were grown in bioreactors, harvested and dried before analysis. The commercial fungal product Quorn was used as a reference. The protein digestibility of the microbial samp...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Nordlund Emilia Silventoinen-Veijalainen Pia Hyyti äinen-Pabst Tiina Nyyss ölä Antti Valtonen Anniina Ritala Anneli Lienemann Michael Rosa-Sibakov Natalia Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
Effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture on anterior dentition defects with minimal vertical intermaxillary space
CONCLUSION: Orthodontics combined with FRC-RBFPD shows an ideal restorative effect on patients with anterior dentition defects and minimal vertical intermaxillary space.PMID:38517820 | DOI:10.3233/THC-231889 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Shi-Lei Han Na Li Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
Effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture on anterior dentition defects with minimal vertical intermaxillary space
CONCLUSION: Orthodontics combined with FRC-RBFPD shows an ideal restorative effect on patients with anterior dentition defects and minimal vertical intermaxillary space.PMID:38517820 | DOI:10.3233/THC-231889 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Shi-Lei Han Na Li Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
Effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture on anterior dentition defects with minimal vertical intermaxillary space
CONCLUSION: Orthodontics combined with FRC-RBFPD shows an ideal restorative effect on patients with anterior dentition defects and minimal vertical intermaxillary space.PMID:38517820 | DOI:10.3233/THC-231889 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Shi-Lei Han Na Li Source Type: research
Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
