Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
ConclusionThis study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, our novel findings regarding the efficacy of UA in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future. (Source: Military Medical Research)
Source: Military Medical Research - March 11, 2024 Category: International Medicine & Public Health Source Type: research
Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure
Particulate matter 2.5 (PM2.5) deposition in the lung ’s alveolar capillary region (ACR) is significantly associated with respiratory disease development, yet the molecular mechanisms are not completely understood... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 11, 2024 Category: Toxicology Authors: Eva C. M. Vitucci, Alysha E. Simmons, Elizabeth M. Martin and Shaun D. McCullough Tags: Research Source Type: research
Monitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air –liquid interface
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, v... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 8, 2024 Category: Toxicology Authors: Aiman Abzhanova, Jon Berntsen, Edward R. Pennington, Lisa Dailey, Syed Masood, Ingrid George, Nina Warren, Joseph Martin, Michael D. Hays, Andrew J. Ghio, Jason P. Weinstein, Yong Ho Kim, Earl Puckett and James M. Samet Tags: Research Source Type: research
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage
With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention. MPs have been detected out in h... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 7, 2024 Category: Toxicology Authors: Shukun Wan, Xiaoqing Wang, Weina Chen, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng and Huidong Zhang Tags: Research Source Type: research
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment
Chronic inflammation and fibrosis are characteristics of silicosis, and the inflammatory mediators involved in silicosis have not been fully elucidated. Recently, macrophage-derived exosomes have been reported... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 7, 2024 Category: Toxicology Authors: Xiaofeng Qin, Zhiyuan Niu, Hui Chen and Yongbin Hu Tags: Research Source Type: research
Correction: Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life
(Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 6, 2024 Category: Toxicology Authors: Caroline Carl é, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanu Tags: Correction Source Type: research
Electron-Donating Conjugation Effect Modulated Zn2+ Reduction Reaction for Separator-Free Aqueous Zinc Batteries
Angew Chem Int Ed Engl. 2024 Mar 4:e202402987. doi: 10.1002/anie.202402987. Online ahead of print.ABSTRACTZinc-based aqueous batteries (ZABs) are attracting extensive attention due to the low cost, high capacity, and environmental benignity of the zinc anode. However, their application is still hindered by the undesired zinc dendrites. Despite Zn-surface modification being promising in relieving dendrites, a thick separator (i.e. glass fibre, 250-700 µm) is still required to resist dendrite puncture, which limits volumetric energy density of battery. Here, we pivot from the traditional interphase plus extra separator cate...
Source: Angewandte Chemie - March 4, 2024 Category: Chemistry Authors: Zhihao Sun Fanxing Bu Yanyan Zhang Wanhai Zhou Xinran Li Xin Liu Hongrun Jin Shixiang Ding Tengsheng Zhang Lipeng Wang Hongpeng Li Wei Li Chaofeng Zhang Dongyuan Zhao Yonggang Wang Dongliang Chao Source Type: research
Innovating dialysis through computational modelling of hollow-fibre haemodialysers
Nature Reviews Nephrology, Published online: 04 March 2024; doi:10.1038/s41581-024-00826-0Haemodialyser technology has not advanced much in decades, despite its unresolved shortcomings. Sophisticated new computational tools such as high-fidelity surrogate in silico dialyser models could reduce the time and expense of exploring alternative designs, dialysis dose and operating conditions compared with the current gold standard in vitro studies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 4, 2024 Category: Urology & Nephrology Authors: Ruhit Sinha Michael V. Rocco Pirouz Daeihagh Anne E. Staples Source Type: research
Reorganization of mitochondria-organelle interactions during postnatal development in skeletal muscle
J Physiol. 2024 Mar 1. doi: 10.1113/JP285014. Online ahead of print.ABSTRACTSkeletal muscle cellular development requires the integrated assembly of mitochondria and other organelles adjacent to the sarcomere in support of muscle contractile performance. However, it remains unclear how interactions among organelles and with the sarcomere relates to the development of muscle cell function. Here, we combine 3D volume electron microscopy, proteomic analyses, and live cell functional imaging to investigate the postnatal reorganization of mitochondria-organelle interactions in skeletal muscle. We show that while mitochondrial n...
Source: The Journal of Physiology - March 2, 2024 Category: Physiology Authors: Yuho Kim Hailey A Parry T Bradley Willingham Greg Alspaugh Eric Lindberg Christian A Combs Jay R Knutson Christopher K E Bleck Brian Glancy Source Type: research
Contribution of baby food pouches and other commercial infant foods to the diets of infants: a cross-sectional study
CONCLUSIONS: Baby food pouches make relatively small contributions to energy intake in infants, but are important sources of carbohydrate, fiber, and vitamins A, C and B6. Almost half of the total sugars consumed from complementary foods is provided by these pouches.CLINICAL TRIAL REGISTRY: Australian New Zealand Clinical Trials Registry (registration number: ACTRN12620000459921; website: http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436) for the FFNZ study.PMID:38431120 | DOI:10.1016/j.ajcnut.2024.02.030 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - March 2, 2024 Category: Nutrition Authors: Jillian J Haszard Anne-Louise M Heath Ioanna Katiforis Elizabeth A Fleming Rachael W Taylor Source Type: research
Contribution of baby food pouches and other commercial infant foods to the diets of infants: a cross-sectional study
CONCLUSIONS: Baby food pouches make relatively small contributions to energy intake in infants, but are important sources of carbohydrate, fiber, and vitamins A, C and B6. Almost half of the total sugars consumed from complementary foods is provided by these pouches.CLINICAL TRIAL REGISTRY: Australian New Zealand Clinical Trials Registry (registration number: ACTRN12620000459921; website: http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436) for the FFNZ study.PMID:38431120 | DOI:10.1016/j.ajcnut.2024.02.030 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - March 2, 2024 Category: Nutrition Authors: Jillian J Haszard Anne-Louise M Heath Ioanna Katiforis Elizabeth A Fleming Rachael W Taylor Source Type: research
Reorganization of mitochondria-organelle interactions during postnatal development in skeletal muscle
J Physiol. 2024 Mar 1. doi: 10.1113/JP285014. Online ahead of print.ABSTRACTSkeletal muscle cellular development requires the integrated assembly of mitochondria and other organelles adjacent to the sarcomere in support of muscle contractile performance. However, it remains unclear how interactions among organelles and with the sarcomere relates to the development of muscle cell function. Here, we combine 3D volume electron microscopy, proteomic analyses, and live cell functional imaging to investigate the postnatal reorganization of mitochondria-organelle interactions in skeletal muscle. We show that while mitochondrial n...
Source: The Journal of Physiology - March 2, 2024 Category: Physiology Authors: Yuho Kim Hailey A Parry T Bradley Willingham Greg Alspaugh Eric Lindberg Christian A Combs Jay R Knutson Christopher K E Bleck Brian Glancy Source Type: research
Contribution of baby food pouches and other commercial infant foods to the diets of infants: a cross-sectional study
CONCLUSIONS: Baby food pouches make relatively small contributions to energy intake in infants, but are important sources of carbohydrate, fiber, and vitamins A, C and B6. Almost half of the total sugars consumed from complementary foods is provided by these pouches.CLINICAL TRIAL REGISTRY: Australian New Zealand Clinical Trials Registry (registration number: ACTRN12620000459921; website: http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436) for the FFNZ study.PMID:38431120 | DOI:10.1016/j.ajcnut.2024.02.030 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - March 2, 2024 Category: Nutrition Authors: Jillian J Haszard Anne-Louise M Heath Ioanna Katiforis Elizabeth A Fleming Rachael W Taylor Source Type: research
Contribution of baby food pouches and other commercial infant foods to the diets of infants: a cross-sectional study
CONCLUSIONS: Baby food pouches make relatively small contributions to energy intake in infants, but are important sources of carbohydrate, fiber, and vitamins A, C and B6. Almost half of the total sugars consumed from complementary foods is provided by these pouches.CLINICAL TRIAL REGISTRY: Australian New Zealand Clinical Trials Registry (registration number: ACTRN12620000459921; website: http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436) for the FFNZ study.PMID:38431120 | DOI:10.1016/j.ajcnut.2024.02.030 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - March 2, 2024 Category: Nutrition Authors: Jillian J Haszard Anne-Louise M Heath Ioanna Katiforis Elizabeth A Fleming Rachael W Taylor Source Type: research
Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review
Crystalline silica (cSiO2) is a mineral found in rocks; workers from the construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 inhalation increases the risk of silicosis and... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 1, 2024 Category: Toxicology Authors: Laura Morin, Val érie Lecureur and Alain Lescoat Tags: Review Source Type: research
