Urinary bladder cancer as a late sequela of traumatic spinal cord injury
ConclusionsThe results showed that urinary bladder cancer in SCI patients differs considerably from that in able-bodied patients. The presented algorithm is an important aid in everyday clinical practice for assessing the correlation between SCI and bladder cancer. (Source: Military Medical Research)
Source: Military Medical Research - April 29, 2021 Category: International Medicine & Public Health Source Type: research

Hemopneumothorax detection through the process of artificial evolution - a feasibility study
ConclusionsWe present a novel, objective device for rapid diagnosis of potentially lethal thoracic injuries. With further optimization, such a device could provide real-time detection and monitoring of pneumothorax and hemothorax in battlefield conditions. (Source: Military Medical Research)
Source: Military Medical Research - April 25, 2021 Category: International Medicine & Public Health Source Type: research

Research progress in the effects of terahertz waves on biomacromolecules
AbstractWith the rapid development of terahertz technologies, basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomacromolecules fall in the energy range of terahertz waves; thus, terahertz waves might interact with biomacromolecules. Therefore, terahertz waves have been widely applied to explore features of the terahertz spectrum of biomacromolecules. However, the effects of terahertz waves on biomacromolecules are largely unexplored. Although some progress has been reported, there are still numerous technical barriers to c...
Source: Military Medical Research - April 25, 2021 Category: International Medicine & Public Health Source Type: research

Correction to: Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis
An amendment to this paper has been published and can be accessed via the original article. (Source: Military Medical Research)
Source: Military Medical Research - April 16, 2021 Category: International Medicine & Public Health Source Type: research

Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy
AbstractTrauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly focused on hemorrhagic coagulopathy caused by the hypocoagulable phenotype of TIC, while recent studies have found that trauma-induced hypercoagulopathy can occur in as many as 22.2 –85.1% of trauma patients, in whom it can increase the risk of thrombotic events and mortality by 2- to 4-fold. Therefore, the Chinese People’s Liberation Army Professional Committ...
Source: Military Medical Research - April 12, 2021 Category: International Medicine & Public Health Source Type: research

Correction to: Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules
An amendment to this paper has been published and can be accessed via the original article. (Source: Military Medical Research)
Source: Military Medical Research - April 6, 2021 Category: International Medicine & Public Health Source Type: research

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia
ConclusionNBP improved physical and learning and memory functions in rodents exposed to acute or chronic hypobaric hypoxia by increasing their anti-oxidative capacity and energy supply. (Source: Military Medical Research)
Source: Military Medical Research - March 25, 2021 Category: International Medicine & Public Health Source Type: research

Early stage nonclinical pulmonary disorder in COVID-19 may present asymptomatic and fuel the contagion
AbstractEvidence shows that pulmonary problems in coronavirus disease 2019 (COVID-19) may set off from vascular injury that progresses to physiological disturbances through a compromised gas exchange, following an infection with the severe acute respiratory syndrome coronavirus 2. In this process, inefficient gas exchange in the alveolar could precipitate silent nonclinical hypoxemia. Unfortunately, patients with “silent hypoxemia” do not necessarily experience any breathing difficulty (dyspnea) at the early stage of COVID-19 while the disease progresses. As a result, several asymptomatic, presymptomatic and pa...
Source: Military Medical Research - March 24, 2021 Category: International Medicine & Public Health Source Type: research

Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study
ConclusionsThis nomogram could help clinicians to identify severe patients who have high risk of death, and to develop more appropriate treatment strategies to reduce the mortality of severe patients. Tocilizumab may improve the prognosis of severe COVID-19 patients with high levels of IL-6. (Source: Military Medical Research)
Source: Military Medical Research - March 17, 2021 Category: International Medicine & Public Health Source Type: research

Military medical research on internal diseases in modern warfare: new concepts, demands, challenges, and opportunities
AbstractBattlefield internal medicine aims at the treatment of combatants and noncombatants with various internal diseases on the battlefield. The military medical research on battlefield internal diseases focuses on the pathogenesis, clinical management, and prevention of internal diseases under military war conditions. In both wartime and peacetime, the soldiers suffer from more internal diseases than surgical wounds. With the introduction of high-tech weapons, including chemical, physical, and biological agents, a large number of special internal illnesses and casualties will appear in future wars. The battles often occ...
Source: Military Medical Research - March 12, 2021 Category: International Medicine & Public Health Source Type: research

Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection
ConclusionsThese data revealed a comprehensive circRNA-associated ceRNA network duringT. asahii infection, thus providing new insights into the pathogenesis of theT. asahii-host interactions. (Source: Military Medical Research)
Source: Military Medical Research - March 9, 2021 Category: International Medicine & Public Health Source Type: research

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs
ConclusionsA recombinant human epidermal growth factor (rhEGF) concentration of 10  ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in vitro. VSD combined with rhEGF kept in place for 10 min and then washed, can promote wound healing better than the other treatments in vivo. (Source: Military Medical Research)
Source: Military Medical Research - March 9, 2021 Category: International Medicine & Public Health Source Type: research

Benefits of early ambulation within 24  h after total knee arthroplasty: a multicenter retrospective cohort study in China
ConclusionEarly ambulation within 24  h after TKA was associated with reduced LOS, improved knee function, lower hospitalization costs and lower incidence of DVT and pulmonary infection in the Chinese population. (Source: Military Medical Research)
Source: Military Medical Research - March 5, 2021 Category: International Medicine & Public Health Source Type: research

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
ConclusionWe reveal that TLR5 activation contributes to the initial events of liver regeneration after PHx. Our findings demonstrate that TLR5 signaling positively regulates liver regeneration and suggest the potential of TLR5 agonist to promote liver regeneration. (Source: Military Medical Research)
Source: Military Medical Research - February 23, 2021 Category: International Medicine & Public Health Source Type: research

The effects of 12  weeks of functional strength training on muscle strength, volume and activity upon exposure to elevated G z forces in high-performance aircraft personnel
AbstractBackgroundTechnological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel, including inducing neck and back pain. The purpose of this study was to examine the effects of 12  weeks of functional strength training on 1) the volume and strength of the neck and shoulder muscles and 2) muscular activity upon exposure to helmets of different masses and elevated Gz forces in a long-arm centrifuge in high-performance aircraft personnel.MethodsEighteen participants underwent 12  weeks of functional strength trai...
Source: Military Medical Research - February 23, 2021 Category: International Medicine & Public Health Source Type: research

Establishment of injury models in studies of biological effects induced by microwave radiation
AbstractMicrowave radiation has been widely used in various fields, such as communication, industry, medical treatment, and military applications. Microwave radiation may cause injuries to both the structures and functions of various organs, such as the brain, heart, reproductive organs, and endocrine organs, which endanger human health. Therefore, it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave radiation. The successful establishment of injury models is of great importance to the reliability and reproducibility of these studies. In this article, we review...
Source: Military Medical Research - February 18, 2021 Category: International Medicine & Public Health Source Type: research

Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak
AbstractBackgroundUntil January 18, 2021, coronavirus disease-2019 (COVID-19) has infected more than 93 million individuals and has caused a certain degree of panic. Viral pneumonia caused by common viruses such as respiratory syncytial virus, rhinovirus, human metapneumovirus, human bocavirus, and parainfluenza viruses have been more common in children. However, the incidence of COVID-19 in children was significantly lower than that in adults. The purpose of this study was to describe the clinical manifestations, treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnos...
Source: Military Medical Research - February 16, 2021 Category: International Medicine & Public Health Source Type: research

Association between medical resources and the proportion of oldest-old in the Chinese population
AbstractThe potential association between medical resources and the proportion of oldest-old (90  years of age and above) in the Chinese population was examined, and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers. (Source: Military Medical Research)
Source: Military Medical Research - February 16, 2021 Category: International Medicine & Public Health Source Type: research

Correction to: Combating an invisible enemy: the American military response to global pandemics
An amendment to this paper has been published and can be accessed via the original article. (Source: Military Medical Research)
Source: Military Medical Research - February 4, 2021 Category: International Medicine & Public Health Source Type: research

Development of rapid advice guideline and standard and continuous updating guideline: experiences and practice
AbstractWe published rapid advice guidelines and updated guidelines for coronavirus disease 2019 (COVID-19) management on February 6, 2020, and September 4, 2020, respectively. These two guidelines vary widely in their developmental background, type of evidence, grade of recommendation and so on. We shared our experience for the development of these two guidelines to help clinical practitioners better understand and implement guidelines and to help guideline developers facilitate communication and discussion for guideline development during the pandemic. (Source: Military Medical Research)
Source: Military Medical Research - February 3, 2021 Category: International Medicine & Public Health Source Type: research

Immunotherapeutic strategies targeting B cell maturation antigen in multiple myeloma
AbstractMultiple myeloma (MM) is the second most common hematologic malignancy, and is characterized by the clonal expansion of malignant plasma cells. Despite the recent improvement in patient outcome due to the use of novel therapeutic agents and stem cell transplantation, all patients eventually relapse due to clone evolution. B cell maturation antigen (BCMA) is highly expressed in and specific for MM cells, and has been implicated in the pathogenesis as well as treatment development for MM. In this review, we will summarize representative anti-BCMA immune therapeutic strategies, including BCMA-targeted vaccines, anti-B...
Source: Military Medical Research - January 27, 2021 Category: International Medicine & Public Health Source Type: research

Combating an invisible enemy: the American military response to global pandemics
AbstractThe present moment is not the first time that America has found itself at war with a pathogen during a time of international conflict. Between crowded barracks at home and trenches abroad, wartime conditions helped enable the spread of influenza in the fall of 1918 during World War I such that an estimated 20 –40% of U.S. military members were infected. While the coronavirus disease 2019 (COVID-19) pandemic is unparalleled for most of today’s population, it is essential to not view it as unprecedented lest the lessons of past pandemics and their effect on the American military be forgotten. This arti cl...
Source: Military Medical Research - January 25, 2021 Category: International Medicine & Public Health Source Type: research

A practical approach to imaging characteristics and standardized reporting of COVID-19: a radiologic review
AbstractNovel coronavirus (2019-nCoV), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pathogen that has caused a rapidly spreading pandemic all over the world. The primary mean of transmission is inhalation with a predilection for respiratory system involvement, especially in the distal airways. The disease that arises from this novel coronavirus is named coronavirus disease 2019 (COVID-19). COVID-19 may have a rapid and devastating course in some cases leading to severe complications and death. Radiological imaging methods have an invaluable role in diagnosis, follow-up, and treatment. In...
Source: Military Medical Research - January 24, 2021 Category: International Medicine & Public Health Source Type: research

Research progress of heat stroke during 1989 –2019: a bibliometric analysis
ConclusionsCorresponding to this important field, while the contributions of the publications from the United States were significant, the mismatch between the quantity and quality of publications from China must be examined. Moreover, it is hypothesized that clinical and epidemiological studies may become hotspots in the near future. (Source: Military Medical Research)
Source: Military Medical Research - January 21, 2021 Category: International Medicine & Public Health Source Type: research

Expert consensus on the prevention, diagnosis and treatment of cold injury in China, 2020
AbstractCold injury refers to local or systemic injury caused by a rapid, massive loss of body heat in a cold environment. The incidence of cold injury is high. However, the current situation regarding the diagnosis and treatment of cold injury in our country is not ideal. To standardize and improve the level of clinical diagnosis and treatment of cold injury in China, it is necessary to make a consensus that is practical and adapted to the conditions in China. We used the latest population-level epidemiological and clinical research data, combined with relevant literature from China and foreign countries. The consensus wa...
Source: Military Medical Research - January 21, 2021 Category: International Medicine & Public Health Source Type: research

Correction to: Extremity soft tissue coverage in the combat zone: use of pedicled flap transfers by the deployed orthopedic surgeon
An amendment to this paper has been published and can be accessed via the original article. (Source: Military Medical Research)
Source: Military Medical Research - January 21, 2021 Category: International Medicine & Public Health Source Type: research

Preparing for a “dirty bomb” attack: the optimum mix of medical countermeasure resources
ConclusionTo achieve economic efficiency a high daily screening capacity is of major importance to substantially decrease the required amount of antidote doses. Among the determinants of the number of equipment units needed, the fraction of the potentially contaminated victims that actually needs treatment is the most difficult to assess. Judging cost-effectiveness of the preparedness for “dirty bomb” attacks is an issue of principle that must be dealt with by political leaders. (Source: Military Medical Research)
Source: Military Medical Research - January 17, 2021 Category: International Medicine & Public Health Source Type: research

Repair cell first, then regenerate the tissues and organs
AbstractWound healing, tissue repair and regenerative medicine are in great demand, and great achievements in these fields have been made. The traditional strategy of tissue repair and regeneration has focused on the level of tissues and organs directly; however, the basic process of repair at the cell level is often neglected. Because the cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. Then, damage to tissues and organs occurs with massive cell damage, apoptosis and even cell death. Thus, how to achieve the aim of pe...
Source: Military Medical Research - January 15, 2021 Category: International Medicine & Public Health Source Type: research

SARS-CoV-2: vaccines in the pandemic era
AbstractCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 drugs, researchers from the government, academia and industry are developing vaccines at an unprecedented speed to halt the pandemic. In this review, the results of animal experiments and clinical trials on several vaccine technical platforms are summarized, and several challenges are also discussed to further promote the ...
Source: Military Medical Research - January 6, 2021 Category: International Medicine & Public Health Source Type: research

Spine system changes in soldiers after load carriage training in a plateau environment: a prediction model research
AbstractBackgroundLow back pain is the most common spinal disorder among soldiers, and load carriage training (LCT) is considered the main cause. We aimed to investigate changes in the spine system of soldiers after LCT at high altitudes and the change trend of the lumbar spine and surrounding soft tissues under different load conditions.MethodsMagnetic resonance imaging scans of the lumbar spines of nine soldiers from plateau troops were collected and processed. We used ImageJ and Surgimap software to analyze changes in the lumbar paraspinal muscles, intervertebral discs (IVDs), intervertebral foramina, and curvature. Fur...
Source: Military Medical Research - December 21, 2020 Category: International Medicine & Public Health Source Type: research

Impact of adolescent complex regional pain syndrome on the psychopathology of young men ahead of military service: a retrospective cohort analysis of Korean conscription data
AbstractBackgroundThe relationship between physical and psychopathological features in complex regional pain syndrome (CRPS) has been a subject of constant interest, but no data are available in adolescents. Therefore, we aimed to identify the factors associated with psychopathology in adolescents with CRPS ahead of military service.MethodsWe retrospectively reviewed all conscription examinees who had completed a Military Personality Inventory (MPI) during a period between February 2013 and December 2016. A total of 63 persons with a history of CRPS (19-years of age for all) were enrolled. Basic demographic and pain-relate...
Source: Military Medical Research - December 21, 2020 Category: International Medicine & Public Health Source Type: research

CRISPR/Cas9 from bench to bedside: what clinicians need to know before application?
AbstractIn October 2020, Dr. Emmanuelle Charpentier and Dr. Jennifer Doudna won the Nobel Prize in Chemistry for their pioneering work in precise genome editing using the CRISPR technology. Although CRISPR technology has developed rapidly in the last decade, there are still many uncertainties before eventual use in clinical settings. In this mini review, we summarize the current efforts in addressing the limitations of CRISPR technology and future directions. (Source: Military Medical Research)
Source: Military Medical Research - December 8, 2020 Category: International Medicine & Public Health Source Type: research

Outbreak of Mycoplasma pneumoniae at a military academy
AbstractIn 2019, an outbreak ofMycoplasma pneumoniae occurred at a military academy in China. The attack rate (10.08%,60/595) was significantly different among the units. High-intensity training and crowded environments to which cadets are exposed are the high risk factors for the outbreak ofM. pneumoniae. In-time prevention and control measures effectively controlled the spread of the epidemic. (Source: Military Medical Research)
Source: Military Medical Research - December 3, 2020 Category: International Medicine & Public Health Source Type: research

Hepatitis C: milestones from discovery to clinical  cure
AbstractOn October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “sc ientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting a...
Source: Military Medical Research - December 1, 2020 Category: International Medicine & Public Health Source Type: research

Methods for improving thermal tolerance in military personnel prior to deployment
AbstractAcute exposure to heat, such as that experienced by people arriving into a hotter or more humid environment, can compromise physical and cognitive performance as well as health. In military contexts heat stress is exacerbated by the combination of protective clothing, carried loads, and unique activity profiles, making them susceptible to heat illnesses. As the operational environment is dynamic and unpredictable, strategies to minimize the effects of heat should be planned and conducted prior to deployment. This review explores how heat acclimation (HA) prior to deployment may attenuate the effects of heat by init...
Source: Military Medical Research - November 29, 2020 Category: International Medicine & Public Health Source Type: research

Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury
ConclusionsIn summary, these findings provide an overview of the dynamic changes in cytokines in the SNs and DRGs at different time points after nerve crush injury in rats, elucidate the biological processes of differentially expressed cytokines, especially the important roles in inflammatory and immune responses after peripheral nerve injury, and thus might contribute to the identification of potential treatments for peripheral nerve repair and regeneration. (Source: Military Medical Research)
Source: Military Medical Research - November 23, 2020 Category: International Medicine & Public Health Source Type: research

Effects and mechanism of platelet-rich plasma on military drill injury: a review
AbstractMilitary drill injury is a significant part of military medical research. The increase of training intensity and changes in training methods lead to differences in injury types. The ideal therapeutic modality should allow rapid healing at a reasonable cost and minimize impact on patients ’ life. Platelet -rich plasma (PRP), a platelet concentrate, is rich in a variety of growth factors and widely used clinically as a minimally invasive treatment. It plays an important role in injury repair and rehabilitation. In this article, we review the therapeutic role of PRP in military drill injury and its possible unde...
Source: Military Medical Research - November 22, 2020 Category: International Medicine & Public Health Source Type: research

Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution
AbstractBackgroundPlasma expanders are widely used for acute normovolemic hemodilution (ANH). However, existing studies have not focused on large-volume infusion with colloidal plasma expanders, and there is a lack of studies that compare the effects of different plasma expanders.MethodsThe viscosity, hydrodynamic radius (Rh) and colloid osmotic pressure (COP) of plasma expanders were determined by a cone-plate viscometer, Zetasizer and cut-off membrane, respectively. Sixty male rats were randomized into five groups with Gelofusine (Gel), Hydroxyethyl Starch 200/0.5 (HES200), Hydroxyethyl Starch 130/0.4 (HES130), Hydroxyet...
Source: Military Medical Research - November 11, 2020 Category: International Medicine & Public Health Source Type: research

Biodegradable materials for bone defect repair
AbstractCompared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers. In the treatment of bone defects, scaffolds made of biodegradable materials can provide a crawling bridge for new bone tissue in the gap and a platform for cells and growth factors to play a physiological role, which will eventually be degraded and absorbed in the body and be replaced by the new bone tissue. Traditional biodegradable materials include polymers, ceramics and metals, which have been used in bone defect ...
Source: Military Medical Research - November 10, 2020 Category: International Medicine & Public Health Source Type: research

Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent
AbstractBackgroundAcute mountain sickness (AMS) is the mildest form of acute altitude illnesses, and consists of non-specific symptoms when unacclimatized persons ascend to elevation of ≥2500 m. Risk factors of AMS include: the altitude, individual susceptibility, ascending rate and degree of pre-acclimatization. In the current study, we examined whether physiological response at low altitude could predict the development of AMS.MethodsA total of 111 healthy adult healthy volunteers participated in this trial; and 99 (67 men and 32 women) completed the entire study protocol. Subjects were asked to complete a 9-mi...
Source: Military Medical Research - November 5, 2020 Category: International Medicine & Public Health Source Type: research

Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors
ConclusionWe developed a chemical cocktail of small molecules and protein factors to convert human fibroblasts into DA neuron-like cells without passing through a neural progenitor/stem cell intermediate stage. The induced DA neuron-like cells from human fibroblasts might provide a cellular source for cell-based therapy of Parkinson ’s disease in the future. (Source: Military Medical Research)
Source: Military Medical Research - November 1, 2020 Category: International Medicine & Public Health Source Type: research

Soft tissue coverage using pedicled flap in combat zone: a case series
ConclusionsSoft tissue defect can be managed with simple pedicled flaps in theatre of operations if needed. Basic reconstructive procedures should be part of the training for military orthopedic surgeons.Trial registrationRetrospectively registered in January 2019 (2019-0901-001). (Source: Military Medical Research)
Source: Military Medical Research - October 24, 2020 Category: International Medicine & Public Health Source Type: research

Extremity soft tissue coverage in the combat zone: use of pedicled flap transfers by the deployed orthopedic surgeon
ConclusionsSatisfying results can be achieved by simple pedicled flaps performed by orthopedic surgeons deployed in forward surgical units. Most complications were related to failure of bone infection treatment. The teaching of such basic reconstructive procedures should be part of the training for any military orthopedic surgeon.Trial registrationRetrospectively registered on January 2019 (n °2019–090 1-001). (Source: Military Medical Research)
Source: Military Medical Research - October 24, 2020 Category: International Medicine & Public Health Source Type: research

Correction to: Preliminary evaluation of the Vision PERformance (VIPER) simulator
An amendment to this paper has been published and can be accessed via the original article. (Source: Military Medical Research)
Source: Military Medical Research - October 18, 2020 Category: International Medicine & Public Health Source Type: research

Coronaviruses and gastrointestinal diseases
AbstractThe effects of coronaviruses on the respiratory system are of great concern, but their effects on the digestive system receive much less attention. Coronaviruses that infect mammals have shown gastrointestinal pathogenicity and caused symptoms such as diarrhea and vomiting. Available data have shown that human coronaviruses, including the newly emerged SARS-CoV-2, mainly infect the respiratory system and cause symptoms such as cough and fever, while they may generate gastrointestinal symptoms. However, there is little about the relation between coronavirus and digestive system. This review specifically addresses th...
Source: Military Medical Research - October 14, 2020 Category: International Medicine & Public Health Source Type: research

Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma
In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous cell carcinoma (HNSCC) cell death.MethodsCAL-27 and SCC-25 cells were treated with Ad-DIRAS3 and rAd-p53 to induce re-expression of DIRAS3 and p53 respectively. The effects of DIRAS3 and p53 re-expression on the growth and apoptosis of HNSCC cells were examined by TUNEL assay, flow cytometric analysis and MTT. The effects of DIRAS3 and p53 re-expression on Akt phosphorylation, oncogene expression, and the interaction of 4E-BP1 with eIF4E were determined by real-time PCR, Western blott...
Source: Military Medical Research - October 11, 2020 Category: International Medicine & Public Health Source Type: research

Acute kidney injury in severely injured patients admitted to the intensive care unit
ConclusionWe found that age, APACHE II score, thoracic trauma, lactic acidosis, and dobutamine administration were independently associated with AKI. Trauma surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients. (Source: Military Medical Research)
Source: Military Medical Research - October 9, 2020 Category: International Medicine & Public Health Source Type: research

Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study
We report the study protocol of a pilot study funded under the South-Central Mental Illness Research, Education, and Clinical Center pilot study program from the U.S. Department of Veterans Affairs. This randomized, open-label study was designed to evaluate the feasibility of completing a randomized trial of quetiapine vs. treatment as usual to promote patient engagement in PTSD patients with a history of mTBI.DiscussionWe expect that the success of this ongoing study should provide us with the preliminary data necessary to design a full-scale randomized trial. Positive efficacy results in a full- scale trial should inform...
Source: Military Medical Research - October 8, 2020 Category: International Medicine & Public Health Source Type: research

Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma
ConclusionWhen COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment, alternative therapy with convalescent plasma administration may be considered. (Source: Military Medical Research)
Source: Military Medical Research - September 22, 2020 Category: International Medicine & Public Health Source Type: research

Mental health status in veterans residing in rural versus non-rural areas: results from the veterans ’ health study
ConclusionsRural residence is associated with lower mental health service use, but not with poor mental health in veterans with former warzone deployment, suggesting rural residence is possibly protective. (Source: Military Medical Research)
Source: Military Medical Research - September 20, 2020 Category: International Medicine & Public Health Source Type: research