Highly Sensitive D-Shaped Surface Plasmon Resonance-Based Photonic Crystal Fibre Refractive Index Sensor for Cancer Detection
AbstractIn this paper, we propose a highly sensitive Surface Plasmon Resonance-based single-core D-shaped Photonic Crystal Fibre using a nanocomposite material rather than a single metal. Except for a few microscopic air holes, the Photonic fibre is filled with fused silica. Titanium dioxide (\(TiO_2\)) nanoparticles wrapped in a layer of gold (Au) form the nanocomposite, which is the active material used in cancer detection using surface plasmon resonance. The nanocomposite material is deposited on the flat surface of the PCF, followed by an analyte sensing layer (blood cells). This type of analyte infiltration in the D-s...
Source: Plasmonics - March 14, 2024 Category: Biomedical Science Source Type: research
Functional specialisation and coordination of myonuclei
Biol Rev Camb Philos Soc. 2024 Mar 13. doi: 10.1111/brv.13063. Online ahead of print.ABSTRACTMyofibres serve as the functional unit for locomotion, with the sarcomere as fundamental subunit. Running the entire length of this structure are hundreds of myonuclei, located at the periphery of the myofibre, juxtaposed to the plasma membrane. Myonuclear specialisation and clustering at the centre and ends of the fibre are known to be essential for muscle contraction, yet the molecular basis of this regionalisation has remained unclear. While the 'myonuclear domain hypothesis' helped explain how myonuclei can independently govern...
Source: Biological Reviews of the Cambridge Philosophical Society - March 13, 2024 Category: Biology Authors: Amaury Korb Shahragim Tajbakhsh Glenda E Comai Source Type: research
Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
This study introduces the Fibre Optic FLASH Monitor (FOFM), which consists of an array of silica optical fibre-based Cherenkov sensors with a photodetector for signal readout.
Approach: Experiments were conducted at the CLEAR facility at CERN using 200 MeV and 160 MeV electrons to assess the FOFM's response linearity to UHDR (characterised with radiochromic films) required for FLASH radiotherapy. Beam profile measurements made on the FOFM were compared to those using radiochromic film and scintillating Yttrium Aluminium Garnet (YAG) screens.
Main Results: A range of photodetectors were evaluated, with a Com...
Source: Physics in Medicine and Biology - March 13, 2024 Category: Physics Authors: Joseph John Bateman Emma Buchanan Roberto Corsini Wilfrid Farabolini Pierre Korysko Robert Garbrecht Larsen Alexander Malyzhenkov I ñaki Ortega Ruiz Vilde Rieker Alexander Gerbershagen Manjit Dosanjh Source Type: research
Dynamic monitoring of radiation-induced white matter microstructure injury in nasopharyngeal carcinoma via high-angular resolution diffusion imaging
CONCLUSIONS: White matter tract changes detected by HARDI are potential biomarkers for monitoring radiotherapy-related brain damage in NPC patients.PMID:38479491 | DOI:10.1016/j.brainres.2024.148851 (Source: Brain Research)
Source: Brain Research - March 13, 2024 Category: Neurology Authors: Tiansheng Li Yihao Guo Xin Jin Tao Liu Gang Wu Weiyuan Huang Feng Chen Source Type: research
Functional specialisation and coordination of myonuclei
Biol Rev Camb Philos Soc. 2024 Mar 13. doi: 10.1111/brv.13063. Online ahead of print.ABSTRACTMyofibres serve as the functional unit for locomotion, with the sarcomere as fundamental subunit. Running the entire length of this structure are hundreds of myonuclei, located at the periphery of the myofibre, juxtaposed to the plasma membrane. Myonuclear specialisation and clustering at the centre and ends of the fibre are known to be essential for muscle contraction, yet the molecular basis of this regionalisation has remained unclear. While the 'myonuclear domain hypothesis' helped explain how myonuclei can independently govern...
Source: Biological Reviews of the Cambridge Philosophical Society - March 13, 2024 Category: Biology Authors: Amaury Korb Shahragim Tajbakhsh Glenda E Comai Source Type: research
Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
This study introduces the Fibre Optic FLASH Monitor (FOFM), which consists of an array of silica optical fibre-based Cherenkov sensors with a photodetector for signal readout.
Approach: Experiments were conducted at the CLEAR facility at CERN using 200 MeV and 160 MeV electrons to assess the FOFM's response linearity to UHDR (characterised with radiochromic films) required for FLASH radiotherapy. Beam profile measurements made on the FOFM were compared to those using radiochromic film and scintillating Yttrium Aluminium Garnet (YAG) screens.
Main Results: A range of photodetectors were evaluated, with a Com...
Source: Physics in Medicine and Biology - March 13, 2024 Category: Physics Authors: Joseph John Bateman Emma Buchanan Roberto Corsini Wilfrid Farabolini Pierre Korysko Robert Garbrecht Larsen Alexander Malyzhenkov I ñaki Ortega Ruiz Vilde Rieker Alexander Gerbershagen Manjit Dosanjh Source Type: research
Functional specialisation and coordination of myonuclei
Biol Rev Camb Philos Soc. 2024 Mar 13. doi: 10.1111/brv.13063. Online ahead of print.ABSTRACTMyofibres serve as the functional unit for locomotion, with the sarcomere as fundamental subunit. Running the entire length of this structure are hundreds of myonuclei, located at the periphery of the myofibre, juxtaposed to the plasma membrane. Myonuclear specialisation and clustering at the centre and ends of the fibre are known to be essential for muscle contraction, yet the molecular basis of this regionalisation has remained unclear. While the 'myonuclear domain hypothesis' helped explain how myonuclei can independently govern...
Source: Biological Reviews of the Cambridge Philosophical Society - March 13, 2024 Category: Biology Authors: Amaury Korb Shahragim Tajbakhsh Glenda E Comai Source Type: research
Functional specialisation and coordination of myonuclei
Biol Rev Camb Philos Soc. 2024 Mar 13. doi: 10.1111/brv.13063. Online ahead of print.ABSTRACTMyofibres serve as the functional unit for locomotion, with the sarcomere as fundamental subunit. Running the entire length of this structure are hundreds of myonuclei, located at the periphery of the myofibre, juxtaposed to the plasma membrane. Myonuclear specialisation and clustering at the centre and ends of the fibre are known to be essential for muscle contraction, yet the molecular basis of this regionalisation has remained unclear. While the 'myonuclear domain hypothesis' helped explain how myonuclei can independently govern...
Source: Biological Reviews of the Cambridge Philosophical Society - March 13, 2024 Category: Biology Authors: Amaury Korb Shahragim Tajbakhsh Glenda E Comai Source Type: research
Oat protein modulates cholesterol metabolism and improves cardiac systolic function in high fat, high sucrose fed rats
Applied Physiology, Nutrition, and Metabolism, Ahead of Print. Oats are recognized to provide many health benefits that are mainly associated with its dietary fibre, β-glucan. However, the protein derived from oats is largely understudied with respect to its ability to maintain health and attenuate risk factors of chronic diseases. The goal of the current study was to investigate the metabolic effects of oat protein consumption in lieu of casein as the protein source in high fat, high sucrose (HF/HS) fed Wistar rats. Four-week-old rats were divided into three groups and were fed three different experimental diets: a contr...
Source: Applied Physiology, Nutrition, and Metabolism - March 13, 2024 Category: Physiology Authors: Jenny Bouchard Pema Raj Liping Yu Babak Sobhi Maneka Malalgoda Lovemore Malunga Thomas Netticadan Sijo Joseph Thandapilly Source Type: research
Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 12, 2024 Category: Respiratory Medicine Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research
The anteromedial retinaculum in ACL-injured knees: An overlooked injury?
CONCLUSION: Data from this study suggest that injuries to the AMR are much more common than posteromedial lesions in subjects with ACL injuries.LEVEL OF EVIDENCE: Level IV.PMID:38469949 | DOI:10.1002/ksa.12137 (Source: Hand Surgery)
Source: Hand Surgery - March 12, 2024 Category: Surgery Authors: Ole Grunenberg Mirjam Gerwing Simon Oeckenp öhler Christian Peez Thorben Briese Johannes Glasbrenner Luise M H ägerich Michael J Raschke Christoph Kittl Elmar Herbst Source Type: research
Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research
Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 12, 2024 Category: Respiratory Medicine Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research
The anteromedial retinaculum in ACL-injured knees: An overlooked injury?
CONCLUSION: Data from this study suggest that injuries to the AMR are much more common than posteromedial lesions in subjects with ACL injuries.LEVEL OF EVIDENCE: Level IV.PMID:38469949 | DOI:10.1002/ksa.12137 (Source: Hand Surgery)
Source: Hand Surgery - March 12, 2024 Category: Surgery Authors: Ole Grunenberg Mirjam Gerwing Simon Oeckenp öhler Christian Peez Thorben Briese Johannes Glasbrenner Luise M H ägerich Michael J Raschke Christoph Kittl Elmar Herbst Source Type: research
Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research
