Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure

In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022

Source: Am J Physiol Lung Ce... - March 12, 2024 Category: Respiratory Medicine Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research