Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)
Mol Med Rep. 2024 May;29(5):82. doi: 10.3892/mmr.2024.13207. Epub 2024 Mar 22.ABSTRACTGlaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Qiongrong Xia Dingding Zhang Source Type: research
In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches
Organomodified nanoclays (ONC), two-dimensional montmorillonite with organic coatings, are increasingly used to improve nanocomposite properties. However, little is known about pulmonary health risks along the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 21, 2024 Category: Toxicology Authors: Todd A. Stueckle, Jake Jensen, Jayme P. Coyle, Raymond Derk, Alixandra Wagner, Cerasela Zoica Dinu, Tiffany G. Kornberg, Sherri A. Friend, Alan Dozier, Sushant Agarwal, Rakesh K. Gupta and Liying W. Rojanasakul Tags: Research Source Type: research
Association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline
Conclusions and relevance
Retinal OCT measurements are significantly associated with genetic risk of neurodegenerative disease and may serve as biomarkers predictive of future cognitive impairment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - March 20, 2024 Category: Opthalmology Authors: Sekimitsu, S., Shweikh, Y., Shareef, S., Zhao, Y., Elze, T., Segre, A., Wiggs, J., Zebardast, N. Tags: Neuro-ophthalmology and strabismus Source Type: research
Papillary vitreous detachment as a possible accomplice in non-arteritic anterior ischaemic optic neuropathy
Conclusion
Peripapillary wrinkles and superficial vessel protrusion may be signs of papillary vitreous detachment-related traction in NAION. Papillary vitreous detachment may play an important role in NAION pathogenesis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - March 20, 2024 Category: Opthalmology Authors: Li, D., Sun, S., Liang, J., Yue, Y., Yang, J., Zhi, Y., Zhang, X., Yu, R., Li, X. Tags: Open access Neuro-ophthalmology and strabismus Source Type: research
Sensors, Vol. 24, Pages 1980: Damage Detection in Glass Fibre Composites Using Cointegrated Hyperspectral Images
In this study, a data conditioning procedure is proposed for improving the results of damage detection with various classifiers. The developed procedure is based on the concept of signal stationarity and cointegration analysis, and achieves its goal by performing the detection and removal of the non-stationary trends in hyperspectral images caused by imperfect lighting. To evaluate the effectiveness of the proposed method, two damage detection tests have been performed on a damaged GFRP specimen: one using the proposed method, and one using an established damage detection workflow, based on the works of other authors. Appl...
Source: Sensors - March 20, 2024 Category: Biotechnology Authors: Jan D ługosz Phong B. Dao Wies ław J. Staszewski Tadeusz Uhl Tags: Article Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Demographic, clinical, and sociocognitive determinants related to physical activity and dietary intake in patients with ovarian cancer: A cross-sectional study
CONCLUSIONS: Patients with ovarian cancer have low physical activity levels and a suboptimal diet, particularly low fruit and vegetable consumption and dietary fibre intake. Interventions aiming to improve physical activity and dietary intake could focus on increasing self-efficacy and outcome expectations, and should consider age and comorbidity as factors that may impact behaviour.TRIAL REGISTRATION: Netherlands Trial Registry NTR6300.PMID:38503140 | DOI:10.1016/j.ygyno.2024.03.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 19, 2024 Category: Cancer & Oncology Authors: Yvonne A W Hartman Marlou-Floor Kenkhuis Stephanie Stelten Calvin G Brouwer Luc R C W van Lonkhuijzen Gemma G Kenter Willemien J van Driel Renate M Winkels Ruud L M Bekkers Nelleke P B Ottevanger Meeke Hoedjes Laurien M Buffart Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Demographic, clinical, and sociocognitive determinants related to physical activity and dietary intake in patients with ovarian cancer: A cross-sectional study
CONCLUSIONS: Patients with ovarian cancer have low physical activity levels and a suboptimal diet, particularly low fruit and vegetable consumption and dietary fibre intake. Interventions aiming to improve physical activity and dietary intake could focus on increasing self-efficacy and outcome expectations, and should consider age and comorbidity as factors that may impact behaviour.TRIAL REGISTRATION: Netherlands Trial Registry NTR6300.PMID:38503140 | DOI:10.1016/j.ygyno.2024.03.007 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 19, 2024 Category: Cancer & Oncology Authors: Yvonne A W Hartman Marlou-Floor Kenkhuis Stephanie Stelten Calvin G Brouwer Luc R C W van Lonkhuijzen Gemma G Kenter Willemien J van Driel Renate M Winkels Ruud L M Bekkers Nelleke P B Ottevanger Meeke Hoedjes Laurien M Buffart Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Near-real-time Mueller polarimetric image processing for neurosurgical intervention
Conclusion:The end-to-end image processing achieved real-time performance for a localised field of view (\(\approx 6.5\ \text {mm}^2\)). The denoised polarimetric intensities produced visibly clear directional patterns of neuronal fibre tracts in line with reference polarimetric image quality standards; directional disruption was kept in case of neoplastic lesions. The presented advances pave the way towards feasible oncological neurosurgical translations of novel, label-free, interventional feedback. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - March 19, 2024 Category: Intensive Care Source Type: research
HairNet2: deep learning to quantify cotton leaf hairiness, a complex genetic and environmental trait
Cotton accounts for 80% of the global natural fibre production. Its leaf hairiness affects insect resistance, fibre yield, and economic value. However, this phenotype is still qualitatively assessed by visuall... (Source: Plant Methods)
Source: Plant Methods - March 19, 2024 Category: Biology Authors: Moshiur Farazi, Warren C. Conaty, Lucy Egan, Susan P. J. Thompson, Iain W. Wilson, Shiming Liu, Warwick N. Stiller, Lars Petersson and Vivien Rolland Tags: Methodology Source Type: research
Fibre-based fluorescence-lifetime imaging microscopy: a real-time biopsy guidance tool for suspected lung cancer
Transl Lung Cancer Res. 2024 Feb 29;13(2):355-361. doi: 10.21037/tlcr-23-638. Epub 2024 Feb 28.ABSTRACTLung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime imaging microscopy (FLIM), a technique which measures endogenous fluorophore decay rates, may aid identification of optimal biopsy sites in suspected lung cancer. Our fibre-based fluorescence-lifetime imaging system, utilising 488 nm excitation, which...
Source: Cell Research - March 18, 2024 Category: Cytology Authors: Susan Fernandes Elvira Williams Neil Finlayson Hazel Stewart Catharine Dhaliwal David A Dorward William A Wallace Ahsan R Akram James Stone Kevin Dhaliwal Gareth O S Williams Source Type: research
Corneal nerves and amyotrophic lateral sclerosis: an in vivo corneal confocal imaging study
ConclusionsThe present study does not support the use of in vivo corneal confocal microscopy as an early diagnostic or prognostic tool for ALS. Further research, especially longitudinal investigations, is needed to understand any potential corneal innervation changes as ALS progresses. (Source: Journal of Neurology)
Source: Journal of Neurology - March 18, 2024 Category: Neurology Source Type: research
