Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in < em > Fxr < /em > -null mice
This study aims to determine the effect of TMAO on NAFLD. A diet containing 0.3% TMAO was fed to farnesoid X receptor (Fxr)-null mice, a model of NAFLD, for 13 weeks. Fxr-null mice fed TMAO showed significant reductions in liver damage markers but not wild-type mice. Hepatic bile acid and cholesterol levels were significantly decreased, and triacylglycerol levels tended to decrease in TMAO-fed Fxr-null mice. Changes in mRNA levels of hepatic bile acid and cholesterol transporters and synthetic enzymes were observed, which could explain the decreased hepatic bile acid and cholesterol levels in Fxr-null mice given the TMAO d...
Source: International Journal of Food Sciences and Nutrition - May 1, 2024 Category: Nutrition Authors: Masaaki Miyata Kento Takeda Sayuri Nagira Yoshimasa Sugiura Source Type: research
Comorbidity and multimorbidity in patients with cirrhosis, hospitalised in an internal medicine ward: a monocentric, cross-sectional study
Conclusions
Comorbidity is more common in alcohol cirrhosis compared with other aetiologies in a hospital, internal medicine setting. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Lenti, M. V., Ballesio, A., Croce, G., Brera, A. S., Padovini, L., Bertolino, G., Di Sabatino, A., Klersy, C., Corazza, G. R. Tags: Open access, Gastroenterology and hepatology Source Type: research
Plasma exchange improves survival in acute liver failure - An updated systematic review and meta-analysis focussed on comparing within single etiology
ConclusionPLEX is safe and improves survival, independent of the volumes utilized, in patients with ALF as compared to standard medical treatment. The survival benefit is especially pronounced in studies restricted to single etiology.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Source Type: research
Acute liver failure in pregnancy
AbstractLiver function abnormalities are noted in a minority of pregnancies with multiple causes for the same. A small proportion of these develop severe liver injury and progress to acute liver failure (ALF). There is a discrete set of etiology for ALF in pregnancy and comprehensive understanding will help in urgent evaluation. Certain diseases such as acute fatty liver of pregnancy, hemolysis, elevated liver enzyme, low platelet (HELLP) syndrome and pre-eclampsia are secondary to pregnant state and can present as ALF. Quick and targeted evaluation with urgent institution of etiology-specific management, especially urge...
Source: Indian Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Source Type: research
Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study
This study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma (HCC) associated with metabolic dysfunction-related fatty liver dis... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Da-Long Yang, Shao-Ping Liu, Hong-Liang Wang, Jian-Rong Li, Jia-Yong Su, Min-Jun Li, Yu-Xian Teng, Zhu-Jian Deng, Zhong-Hai Li, Jian-Li Huang, Ping-Ping Guo, Liang Ma, Zhen-Zhen Li and Jian-Hong Zhong Tags: Research Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
A consortium of < em > Hordeum vulgare < /em > and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):250-260. doi: 10.1080/21691401.2024.2347380. Epub 2024 Apr 30.ABSTRACTDespite many recent studies on non-alcoholic fatty liver disease (NAFLD) therapeutics, the optimal treatment has yet to be determined. In this unfinished project, we combined secondary metabolites (SMs) from the gut microbiota (GM) and Hordeum vulgare (HV) to investigate their combinatorial effects via network pharmacology (NP). Additionally, we analyzed GM or barley - signalling pathways - targets - metabolites (GBSTMs) in combinatorial perspectives (HV, and GM). A total of 31 key targets were analysed via ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been Lee Haripriya Gupta Byeong-Hyun Min Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Sang Youn Lee Mi-Ran Choi Dong Joon Kim Ki-Kwang Oh Ki-Tae Suk Source Type: research
Prognostic value of liver stiffness in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis
CONCLUSIONS: Metabolic dysfunction-associated steatotic liver disease patients with high liver stiffness measurement values were at an increased risk of liver-related events. Liver stiffness measurement can be used as a prognostic tool to achieve risk stratification in fatty liver patients.PMID:38685902 | DOI:10.17235/reed.2024.10353/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - April 30, 2024 Category: Gastroenterology Authors: Yijun Mu Cheng Peng Huijun Chang Shaotong Wang Xiuli Zuo Source Type: research
Multi-omics approach characterizes the role of Bisphenol F in disrupting hepatic lipid metabolism
Environ Int. 2024 Apr 24;187:108690. doi: 10.1016/j.envint.2024.108690. Online ahead of print.ABSTRACTBisphenol F (BPF), a substitute for bisphenol A (BPA), is ubiquitous existed in various environmental media. Exposure to BPF may promote non-alcoholic fatty liver disease (NAFLD), while the potential mechanism is still unknown. In current study, we used in vitro and in vivo model to evaluate its hepatotoxicity and molecular mechanism. Using multi-omics approach, we found that BPF exposure led to changes in hepatic transcriptome, metabolome and chromatin accessible regions that were enriched for binding sites of transcripti...
Source: Environment International - April 30, 2024 Category: Environmental Health Authors: Yun Fan Shiqi Li Xiancheng Yang Shengjun Bai Min Tang Xueer Zhang Chuncheng Lu Chenbo Ji Guizhen Du Yufeng Qin Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
