Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
World J Gastroenterol. 2024 Mar 21;30(11):1480-1487. doi: 10.3748/wjg.v30.i11.1480.ABSTRACTDuring the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleuk...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis Source Type: research
Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms
Planta Med DOI: 10.1055/a-2277-4805Non-alcoholic fatty liver disease (NAFLD), with a global prevalence of 25%, continues to escalate, creating noteworthy concerns towards the global health burden. NAFLD causes triglycerides and free fatty acids to build up in the liver. The excessive fat build-up causes inflammation and damages the healthy hepatocytes, leading to non-alcoholic steatohepatitis (NASH). Dietary habits, obesity, insulin resistance, type 2 diabetes, and dyslipidemia influence NAFLD progression. The disease burden is complicated due to the paucity of therapeutic interventions. Obeticholic acid is the only approv...
Source: Planta Medica - April 15, 2024 Category: Drugs & Pharmacology Authors: Banerjee, Tanmoy Sarkar, Arnab Ali, Sk Zeeshan Bhowmik, Rudranil Karmakar, Sanmoy Halder, Amit Kumar Ghosh, Nilanjan Tags: Reviews Source Type: research
Metabolic Syndrome and Cardiac Vessel Remodeling Associated with Vessel Rarefaction: A Possible Underlying Mechanism May Result from a Poor Angiogenic Response to Altered VEGF Signaling Pathways
J Vasc Res. 2024 Apr 12:1-9. doi: 10.1159/000538361. Online ahead of print.ABSTRACTBACKGROUND: Elevated mortality rates in patients with metabolic syndrome (MetS) are partly due to adverse remodeling of multiple organs, which may lead to cardiovascular disease, nonalcoholic fatty liver disease, kidney failure, or other conditions. MetS symptoms, such as obesity, hypertension, hyperglycemia, dyslipidemia, associated with insulin and leptin resistance, are recognized as major cardiovascular risk factors that adversely affect the heart.SUMMARY: Pathological cardiac remodeling is accompanied by endothelial cell dysfunction whi...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Krzysztof Bartkowiak Mateusz Bartkowiak Ewa Jankowska-Steifer Anna Ratajska Marek Kujawa Olga Anio łek Justyna Niderla-Bieli ńska Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population
The diagnosis and comprehension of nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) are gaining a better understanding. In this s... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 14, 2024 Category: Lipidology Authors: Chenbing Liu, Nan Li, Di Sheng, Yahong Shao, Lihong Qiu, Chao Shen and Zhong Liu Tags: Research Source Type: research
Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea
Ecotoxicol Environ Saf. 2024 Apr 12;276:116310. doi: 10.1016/j.ecoenv.2024.116310. Online ahead of print.ABSTRACTEndocrine-disrupting chemicals (EDCs) may play a role in non-alcoholic fatty liver disease (NAFLD); however, studies on the combined effects of EDC mixtures on NAFLD development are limited. Here, we explored the association between exposure to EDC mixtures and NAFLD and investigated the potential mediating role of metabolic syndrome (MetS). We included participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020) and quantified the urinary concentrations of various EDCs-eight phthalate m...
Source: Ecotoxicology and Environmental Safety - April 13, 2024 Category: Environmental Health Authors: Bohyun Park Byungmi Kim Chung Ho Kim Hyun Jin Oh Bomi Park Source Type: research
Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea
Ecotoxicol Environ Saf. 2024 Apr 12;276:116310. doi: 10.1016/j.ecoenv.2024.116310. Online ahead of print.ABSTRACTEndocrine-disrupting chemicals (EDCs) may play a role in non-alcoholic fatty liver disease (NAFLD); however, studies on the combined effects of EDC mixtures on NAFLD development are limited. Here, we explored the association between exposure to EDC mixtures and NAFLD and investigated the potential mediating role of metabolic syndrome (MetS). We included participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020) and quantified the urinary concentrations of various EDCs-eight phthalate m...
Source: Ecotoxicology and Environmental Safety - April 13, 2024 Category: Environmental Health Authors: Bohyun Park Byungmi Kim Chung Ho Kim Hyun Jin Oh Bomi Park Source Type: research
