Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways
CONCLUSION: Our experiments proved that TFBP has the therapeutic effect in NAFLD, and the activation of Nrf2 and AMPK signaling pathways should make sense.PMID:38649009 | DOI:10.1016/j.bbalip.2024.159497 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Qi Wang Yunfei Wei Yeling Wang Ziyang Yu Haiyan Qin Lilei Zhao Jiaqi Cheng Bingyu Shen Meiyu Jin Haihua Feng Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2
The past few decades have witnessed a rapid growth in the prevalence of nonalcoholic fatty liver disease (NAFLD). While the ketogenic diet (KD) is considered for managing NAFLD, the safety and efficacy of the KD on NAFLD has been a controversial topic. Here, we aimed to investigate the effect of KD of different durations on metabolic endpoints in mice with NAFLD and explore the underlying mechanisms. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 22, 2024 Category: Nutrition Authors: Yuehua You, Yi Huang, Xiaoyang Wang, Hongbin Ni, Qin Ma, Haiying Ran, Jingshu Cai, Xiaojing Lin, Ting Luo, Chaodong Wu, Xiaoqiu Xiao, Li Ma Source Type: research
MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo and Hong Xu Tags: Research Source Type: research
Relationship between sarcopenia and fatty liver in middle-aged and elderly patients with type 2 diabetes mellitus
In this study, we investigated the relationship between sarcopenia and fatty liver in middle-aged and elderly patients diagnosed with type 2 diabetes mellitus (T2DM) to provide a theoretical foundation for the... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - April 20, 2024 Category: Orthopaedics Authors: Li Quan, Fang Zhang, Jing Xu, Fei Wang and Yong Fan Tags: Research article Source Type: research
Role of ghrelin hormone in the development of alcohol-associated liver disease
In this study, we used a ghrelin receptor (GHSR) knockout (KO) rat model to characterize the specific contribution of ghrelin in the development of ALD with emphasis on energy homeostasis. Male Wistar wild type (WT) and GHSR-KO rats were pair-fed the Lieber-DeCarli control or ethanol diet for 6 weeks. At the end of the feeding period, glucose tolerance test was conducted, and tissue samples were collected. We observed reduced alcohol intake by GHSR-KOs compared to a previous study where WT rats were fed ethanol diet ad libitum. Further, when the WTs were pair-fed to GHSR-KOs, the KO rats exhibited resistance to develop ALD...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Sundararajan Mahalingam Ramesh Bellamkonda Kusum K Kharbanda Madan Kumar Arumugam Vikas Kumar Carol A Casey Lorenzo Leggio Karuna Rasineni Source Type: research
Mixed exposure to haloacetaldehyde disinfection by-products exacerbates lipid aggregation in the liver of mice
Environ Pollut. 2024 Apr 17:123971. doi: 10.1016/j.envpol.2024.123971. Online ahead of print.ABSTRACTHaloacetaldehyde disinfection by-products (HAL-DBPs) are among the top three unregulated DBPs found in drinking water. The cytotoxicity and genotoxicity of HALs are much higher than that of the regulated trihalomethanes and haloacetic acids. Previous studies have mainly focused on the toxic effects of single HALs, with few examining the toxic effects of mixed exposures to HALs. The study aimed to observe the effects of mixed exposures of 1∼1000X the realistic level of HALs on the hepatotoxicity and lipid metabolism of C57...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Meiyue Qiu Lili Yang Zhiqiang Jiang Yu Chen Qinxin Liu Xia Wang Weidong Qu Source Type: research
Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress
This study provides a potential molecular mechanism underlying the anti-inflammatory effects of DTPP on NAFLD and suggests DTPP as a promising therapeutic strategy for NAFLD treatment.PMID:38640721 | DOI:10.1016/j.bioorg.2024.107369 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - April 19, 2024 Category: Chemistry Authors: Lingzhi Wang Wenxi Li Yinggang Li Gengrui Chen Lijuan Zhao Wu Li Shengwei Wang Chunming Wang Yanxian Feng Yibo Zhang Source Type: research
