Cohort profile: the PERSIAN Dena Cohort Study (PDCS) of non-communicable diseases in Southwest Iran
This study conducted in Dena County is a population-based cohort study as part of the Prospective Epidemiological Research Studies in Iran (PERSIAN). The specific objectives of this study were to estimate the prevalence of region-specific modifiable risk factors and their associations with the incidence of major non-communicable diseases (NCDs).
Participants
This PERSIAN Dena Cohort Study (PDCS) was conducted on 1561 men and 2069 women aged 35–70 years from October 2016 in Dena County, Kohgiluyeh and Boyer-Ahmad Province, Southwest Iran. The overall participation rate was 82.7%.
Findings to date
Out of 3630 partici...
Source: BMJ Open - April 10, 2024 Category: General Medicine Authors: Harooni, J., Joukar, F., Goujani, R., Sikaroudi, M. K., Hatami, A., Zolghadrpour, M.-A., Hejazi, M., Karimi, Z., Rahmanpour, F., Askari Shahid, S., Jowshan, M.-R. Tags: Open access, Epidemiology Source Type: research
Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review
Introduction
Metabolic dysfunction-associated fatty liver disease (MASLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease worldwide. Given that there is no pharmacological treatment for MASLD, it is imperative to understand whether lifestyle modifications may improve biochemical and pathological outcomes. One commonly proposed dietary modification is the Mediterranean diet; however, vegetarianism may also be a promising intervention. Vegetarianism has been shown to be associated with reduced morbidity and mortality in metabolic syndrome outcomes in coronary artery disease a...
Source: BMJ Open - April 10, 2024 Category: General Medicine Authors: Moss, K., Gitman, V., Pinto Sanchez, M. I., Oczkowski, S., Armstrong, D., Jayakumar, S., Karvellas, C. J., Selzner, N., Dionne, J. Tags: Open access, Gastroenterology and hepatology Source Type: research
Hepatic steatosis predicts metachronous liver metastasis in colorectal cancer patients: a nested case-control study and systematic review
In conclusion, our data suggest that patients with a steatotic liver and a high fibrosis score at CRC diagnosis have elevated risk of developing metachronous CRLM.PMID:38590410 | PMC:PMC10998736 | DOI:10.62347/JHMS4303 (Source: Cancer Control)
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Siqi Dai Chengcheng Liu Lihao Chen Kai Jiang Xiangxing Kong Xiangyuan Li Haiyan Chen Kefeng Ding Source Type: research
Hepatic lipid accumulation is associated with multiple metabolic pathway alterations but not dyslipidemia and insulin resistance in central bearded dragons (Pogona vitticeps)
Am J Vet Res. 2024 Apr 13:1-10. doi: 10.2460/ajvr.23.12.0285. Online ahead of print.ABSTRACTOBJECTIVE: To investigate associations between hepatic fat accumulation, fibrosis, and plasma values of primary metabolites, biochemical measurands, insulin, and lipoproteins in bearded dragons.ANIMALS: 48 adult central bearded dragons (Pogona vitticeps).METHODS: Dragons were sedated with alfaxalone, and a blood sample was collected. Plasma was submitted for untargeted primary metabolomics using gas chromatography time-of-flight mass spectrometry, a biochemistry panel, and a lipoprotein panel determined by PAGE. Hepatic lipid conten...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Hugues Beaufr ère Lisa Pacumio Leonardo Susta Danielle Tarbert M élanie Ammersbach Kevin Keel Source Type: research
StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis
CONCLUSIONS: StarD5's downregulation with hepatic lipid excess is a previously unappreciated physiologic function appearing to promote lipid storage for future needs. Conversely, StarD5's lingering downregulation with prolonged lipid/cholesterol excess accelerates fatty liver's transition to fibrosis; mediated via dysregulation in the oxysterol signaling pathway.PMID:38591148 | DOI:10.1152/ajpgi.00024.2024 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Genta Kakiyama Kei Minowa Nanah Bai-Kamara Taishi Hashiguchi William M Pandak Daniel Rodriguez-Agudo Source Type: research
