Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in < em > Fxr < /em > -null mice
This study aims to determine the effect of TMAO on NAFLD. A diet containing 0.3% TMAO was fed to farnesoid X receptor (Fxr)-null mice, a model of NAFLD, for 13 weeks. Fxr-null mice fed TMAO showed significant reductions in liver damage markers but not wild-type mice. Hepatic bile acid and cholesterol levels were significantly decreased, and triacylglycerol levels tended to decrease in TMAO-fed Fxr-null mice. Changes in mRNA levels of hepatic bile acid and cholesterol transporters and synthetic enzymes were observed, which could explain the decreased hepatic bile acid and cholesterol levels in Fxr-null mice given the TMAO d...
Source: International Journal of Food Sciences and Nutrition - May 1, 2024 Category: Nutrition Authors: Masaaki Miyata Kento Takeda Sayuri Nagira Yoshimasa Sugiura Source Type: research
MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer
This study explores the mechanistic role of fatty liver in CRC progression, focusing on macrophage polarization and lipid metabolism. A murine fatty liver model was created with a high-fat diet (HFD), and CRC was induced using AOM and DSS. Single-cell transcriptome sequencing (scRNA-seq) identified MAPKAP1 as a critical gene promoting CRC via M2 macrophage polarization and lipid metabolism reprogramming. Prognosis analysis on the TCGA-CRC dataset confirmed MAPKAP1's significance. In vitro and in vivo experiments demonstrated that EVs from fatty liver cells enhanced MAPKAP1 expression, accelerating CRC development and metas...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Bo Huang Zhenqiu Yu Dejun Cui Fawang Du Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in < em > Fxr < /em > -null mice
This study aims to determine the effect of TMAO on NAFLD. A diet containing 0.3% TMAO was fed to farnesoid X receptor (Fxr)-null mice, a model of NAFLD, for 13 weeks. Fxr-null mice fed TMAO showed significant reductions in liver damage markers but not wild-type mice. Hepatic bile acid and cholesterol levels were significantly decreased, and triacylglycerol levels tended to decrease in TMAO-fed Fxr-null mice. Changes in mRNA levels of hepatic bile acid and cholesterol transporters and synthetic enzymes were observed, which could explain the decreased hepatic bile acid and cholesterol levels in Fxr-null mice given the TMAO d...
Source: International Journal of Food Sciences and Nutrition - May 1, 2024 Category: Nutrition Authors: Masaaki Miyata Kento Takeda Sayuri Nagira Yoshimasa Sugiura Source Type: research
MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer
This study explores the mechanistic role of fatty liver in CRC progression, focusing on macrophage polarization and lipid metabolism. A murine fatty liver model was created with a high-fat diet (HFD), and CRC was induced using AOM and DSS. Single-cell transcriptome sequencing (scRNA-seq) identified MAPKAP1 as a critical gene promoting CRC via M2 macrophage polarization and lipid metabolism reprogramming. Prognosis analysis on the TCGA-CRC dataset confirmed MAPKAP1's significance. In vitro and in vivo experiments demonstrated that EVs from fatty liver cells enhanced MAPKAP1 expression, accelerating CRC development and metas...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Bo Huang Zhenqiu Yu Dejun Cui Fawang Du Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in < em > Fxr < /em > -null mice
This study aims to determine the effect of TMAO on NAFLD. A diet containing 0.3% TMAO was fed to farnesoid X receptor (Fxr)-null mice, a model of NAFLD, for 13 weeks. Fxr-null mice fed TMAO showed significant reductions in liver damage markers but not wild-type mice. Hepatic bile acid and cholesterol levels were significantly decreased, and triacylglycerol levels tended to decrease in TMAO-fed Fxr-null mice. Changes in mRNA levels of hepatic bile acid and cholesterol transporters and synthetic enzymes were observed, which could explain the decreased hepatic bile acid and cholesterol levels in Fxr-null mice given the TMAO d...
Source: International Journal of Food Sciences and Nutrition - May 1, 2024 Category: Nutrition Authors: Masaaki Miyata Kento Takeda Sayuri Nagira Yoshimasa Sugiura Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
