Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,496 adults using serial echocardiography
CONCLUSIONS: This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.PMID:38608865 | DOI:10.1016/j.diabet.2024.101534 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 12, 2024 Category: Endocrinology Authors: Gyuri Kim Tae Yang Yu Jae Hwan Jee Ji Cheol Bae Mira Kang Jae Hyeon Kim Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography
CONCLUSIONS: This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.PMID:38608865 | DOI:10.1016/j.diabet.2024.101534 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 12, 2024 Category: Endocrinology Authors: Gyuri Kim Tae Yang Yu Jae Hwan Jee Ji Cheol Bae Mira Kang Jae Hyeon Kim Source Type: research
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography
CONCLUSIONS: This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.PMID:38608865 | DOI:10.1016/j.diabet.2024.101534 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 12, 2024 Category: Endocrinology Authors: Gyuri Kim Tae Yang Yu Jae Hwan Jee Ji Cheol Bae Mira Kang Jae Hyeon Kim Source Type: research
GSE260582 Mitochondrial ACSS1-K-635 acetylation mimic knock-in mice exhibit altered lipid metabolism, hepatic cell senescence, and acute non-alcoholic fatty liver [2ndSet_analysis]
Contributors : David Gius ; Guogang Xu ; Joseph Schell ; Nobuo Horikoshi ; Yidong Chen ; Zhao LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated an ACSS1-acetylation (Ac) mimic mouse, where lysine 635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate, and decreased liver/serum ATP and lactate levels. After a 48-hour fast, Acss1K635Q/K635Q mice presented hypothermia and liver aberrations, including enlargement, discoloration, lipid droplet accumulation, and microsteatosis – consistent with nonalco...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE260581 Mitochondrial ACSS1-K-635 acetylation mimic knock-in mice exhibit altered lipid metabolism, hepatic cell senescence, and acute non-alcoholic fatty liver [1stSet_analysis]
Contributors : David Gius ; Guogang Xu ; Joseph Schell ; Nobuo Horikoshi ; Yidong Chen ; Zhao LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated an ACSS1-acetylation (Ac) mimic mouse, where lysine 635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate, and decreased liver/serum ATP and lactate levels. After a 48-hour fast, Acss1K635Q/K635Q mice presented hypothermia and liver aberrations, including enlargement, discoloration, lipid droplet accumulation, and microsteatosis – consistent with nonalco...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Optimal probiotic combinations for treating nonalcoholic fatty liver disease: A systematic review and network meta-analysis
Probiotic administration is a promising therapy for improving conditions in NAFLD patients. This network meta-analysis aimed to compare and estimate the relative effects of probiotic interventions and identify the optimal probiotic species for the treatment of NAFLD (Nonalcoholic fatty liver disease) patients. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 12, 2024 Category: Nutrition Authors: Yafang Yang, Ligang Yang, Jiale Wu, Jing Hu, Min Wan, Jindi Bie, Jiaxin Li, Da Pan, Guiju Sun, Chao Yang Source Type: research
FDA Okays First Drug for Scarring From Fatty Liver Disease
The US Food and Drug Administration (FDA) recently approved resmetirom, marketed as Rezdiffra, for adults with nonalcoholic steatohepatitis (NASH) without cirrhosis. NASH is a progressive fatty liver disease that affects up to 8 million people in the US and can cause liver inflammation and scarring, known as fibrosis. Resmetirom, an oral drug that reduces the accumulation of liver fat, can be used along with diet and exercise, which are the standard care for patients with NASH. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 12, 2024 Category: General Medicine Source Type: research
Would Combination Be Better: Swimming Exercise and Intermittent Fasting Improve High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Obese Rats via the miR-122-5p/SREBP-1c/CPT1A Pathway
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 11, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
CONCLUSION: Most participants with MAFLD had normal ALT levels. Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.PMID:38596503 | PMC:PMC11000085 | DOI:10.3748/wjg.v30.i10.1346 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Jing-Feng Chen Zhuo-Qing Wu Hao-Shuang Liu Su Yan You-Xiang Wang Miao Xing Xiao-Qin Song Su-Ying Ding Source Type: research
Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease
CONCLUSION: The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.PMID:38596499 | PMC:PMC11000086 | DOI:10.3748/wjg.v30.i10.1393 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ming-Hui Zeng Qi-Yu Shi Liang Xu Yu-Qiang Mi Source Type: research
Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
CONCLUSION: Most participants with MAFLD had normal ALT levels. Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.PMID:38596503 | PMC:PMC11000085 | DOI:10.3748/wjg.v30.i10.1346 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Jing-Feng Chen Zhuo-Qing Wu Hao-Shuang Liu Su Yan You-Xiang Wang Miao Xing Xiao-Qin Song Su-Ying Ding Source Type: research
Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease
CONCLUSION: The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.PMID:38596499 | PMC:PMC11000086 | DOI:10.3748/wjg.v30.i10.1393 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ming-Hui Zeng Qi-Yu Shi Liang Xu Yu-Qiang Mi Source Type: research
Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
CONCLUSION: Most participants with MAFLD had normal ALT levels. Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.PMID:38596503 | PMC:PMC11000085 | DOI:10.3748/wjg.v30.i10.1346 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Jing-Feng Chen Zhuo-Qing Wu Hao-Shuang Liu Su Yan You-Xiang Wang Miao Xing Xiao-Qin Song Su-Ying Ding Source Type: research
