Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00013.2024. Online ahead of print.ABSTRACTFatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed quantitative proteomics in lean, glucose-tolerant mice compared to high-fat diet (HFD) fed mice that displayed hepatic steatosis and glucose intolerance as well as high-starch diet (HStD) fed mice who exhibited similar levels of hepatic steatosis but remained glucose tolerant. Both HFD and HStD-fed mice had more and larger LDs t...
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Andries Van Woerkom Dylan J Harney Shilpa R Nagarajan Mariam F Hakeem-Sanni Jinfeng Lin Matthew Hooke Tamara Pilpitel Gregory J Cooney Mark Larance Darren N Saunders Amanda E Brandon Andrew J Hoy Source Type: research
Association between sleep duration and a new onset of nonalcoholic fatty liver disease
Conclusions In women, a short sleep duration was independently associated with the onset of NAFLD, thus suggesting that an adequate sleep duration can be a promising preventive factor for the onset of NAFLD in women.PMID:38658342 | DOI:10.2169/internalmedicine.3119-23 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiromichi Imaizumi Atsushi Takahashi Yosuke Takahata Yukio Anzai Atsuko Kogre Chiharu Sakuma Naoto Abe Tatsuro Sugaya Masashi Fujita Manabu Hayashi Kazumichi Abe Hiromasa Ohira Source Type: research
Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00013.2024. Online ahead of print.ABSTRACTFatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed quantitative proteomics in lean, glucose-tolerant mice compared to high-fat diet (HFD) fed mice that displayed hepatic steatosis and glucose intolerance as well as high-starch diet (HStD) fed mice who exhibited similar levels of hepatic steatosis but remained glucose tolerant. Both HFD and HStD-fed mice had more and larger LDs t...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Andries Van Woerkom Dylan J Harney Shilpa R Nagarajan Mariam F Hakeem-Sanni Jinfeng Lin Matthew Hooke Tamara Pilpitel Gregory J Cooney Mark Larance Darren N Saunders Amanda E Brandon Andrew J Hoy Source Type: research
Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00013.2024. Online ahead of print.ABSTRACTFatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed quantitative proteomics in lean, glucose-tolerant mice compared to high-fat diet (HFD) fed mice that displayed hepatic steatosis and glucose intolerance as well as high-starch diet (HStD) fed mice who exhibited similar levels of hepatic steatosis but remained glucose tolerant. Both HFD and HStD-fed mice had more and larger LDs t...
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Andries Van Woerkom Dylan J Harney Shilpa R Nagarajan Mariam F Hakeem-Sanni Jinfeng Lin Matthew Hooke Tamara Pilpitel Gregory J Cooney Mark Larance Darren N Saunders Amanda E Brandon Andrew J Hoy Source Type: research
Association between sleep duration and a new onset of nonalcoholic fatty liver disease
Conclusions In women, a short sleep duration was independently associated with the onset of NAFLD, thus suggesting that an adequate sleep duration can be a promising preventive factor for the onset of NAFLD in women.PMID:38658342 | DOI:10.2169/internalmedicine.3119-23 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiromichi Imaizumi Atsushi Takahashi Yosuke Takahata Yukio Anzai Atsuko Kogre Chiharu Sakuma Naoto Abe Tatsuro Sugaya Masashi Fujita Manabu Hayashi Kazumichi Abe Hiromasa Ohira Source Type: research
Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
In this study, we engineered aging FGF21 knockout mice of 36 –40 weeks and observed that FGF21 deficiency manifests a spontaneous inflammatory response of lung and abnormal accumulation of lipids in liver. On one hand, inflamed state in lungs and increased circulating inflammatory cytokines were found in FGF21 knockout mice of 36–40 weeks. To evaluate t he ability of FGF21 to suppress inflammation, a subsequent study found that FGF21 knockout aggravated LPS-induced pulmonary exudation and inflammatory infiltration in mice, while exogenous administration of FGF21 reversed these malignant phenotypes by enhancing microv...
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
ConclusioncircSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
Waistline to thigh circumference ratio as a predictor of MAFLD: a health care worker study with 2-year follow-up
This study aimed to determine whether the waist-to-thigh ratio (WTTR) is associated with the incidence of metabolic-associated fatty liver disease (MAFLD) in health care workers. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Xiaoyan Hao, Honghai He, Liyuan Tao, Wei Zhao and Peng Wang Tags: Research Source Type: research
Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
In this study, we engineered aging FGF21 knockout mice of 36 –40 weeks and observed that FGF21 deficiency manifests a spontaneous inflammatory response of lung and abnormal accumulation of lipids in liver. On one hand, inflamed state in lungs and increased circulating inflammatory cytokines were found in FGF21 knockout mice of 36–40 weeks. To evaluate t he ability of FGF21 to suppress inflammation, a subsequent study found that FGF21 knockout aggravated LPS-induced pulmonary exudation and inflammatory infiltration in mice, while exogenous administration of FGF21 reversed these malignant phenotypes by enhancing microv...
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis
CONCLUSION: These findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.PMID:38650638 | PMC:PMC11033504 | DOI:10.3389/fnut.2024.1368459 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Banghe Bao Shuang Xu Peng Sun Liduan Zheng Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Accelerated free-breathing liver fat and < mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" > < mml:mrow > < mml:msubsup > < mml:mi > R < /mml:mi > < mml:mn > 2 < /mml:mn > < mml:mo > * < /mml:mo > < /mml:msubsup > < /mml:mrow > < /mml:math > quantification using multi-echo stack-of-radial MRI with motion-resolved multidimensional regularized reconstruction: Initial retrospective evaluation
CONCLUSION: This proposed method may allow accelerated free-breathing liver PDFF and R 2 * $$ {\mathrm{R}}_2^{\ast } $$ mapping with reduced biases and variations.PMID:38650444 | DOI:10.1002/mrm.30117 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Xiaodong Zhong Marcel D Nickel Stephan A R Kannengiesser Brian M Dale Fei Han Chang Gao Shu-Fu Shih Qing Dai Omar Curiel Tsu-Chin Tsao Holden H Wu Vibhas Deshpande Source Type: research
Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00173-0. doi: 10.1016/j.ejim.2024.04.013. Online ahead of print.ABSTRACTThe medical term nonalcoholic fatty liver disease (NAFLD) was coined in 1986 for a condition that has since become the most prevalent liver disorder worldwide. In the last 3 years, the global professional community launched 2 consecutive efforts to purge NAFLD from the medical dictionary and recommended new terms based on disease pathophysiology rather than distinction from similar conditions featuring liver steatosis. A consensus by renowned clinical scholars primarily residing in the Asian-Pacific region in...
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Piero Portincasa Gyorgy Baffy Source Type: research
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
This study investigated the role of adiposity-associated orphan G protein-coupled receptor 75 (GPR75) in liver lipid accumulation. We profiled Gpr75 expression and report that it is most abundant in the brain. Next, we generated the first single-cell-level analysis of Gpr75 and identified a subpopulation co-expressed with key appetite-regulating hypothalamic neurons. CRISPR-Cas9-deleted Gpr75 mice fed a palatable western diet high in fat adjusted caloric intake to remain in energy balance, thereby preventing NAFLD. Consistent with mouse results, analysis of whole-exome sequencing data from 428,719 individuals (UK Biobank) ...
Source: Cell Metabolism - April 23, 2024 Category: Cytology Authors: Alasdair Leeson-Payne Jean Iyinikkel Cameron Malcolm Brian Y H Lam Nadine Sommer Georgina K C Dowsett Pablo B Martinez de Morentin Dawn Thompson Alasdair Mackenzie Raffaella Chianese Katherine Kentistou Eugene J Gardner John R B Perry Felix Grassmann John Source Type: research
