Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells
Toxicol Lett. 2024 Apr 15;396:11-18. doi: 10.1016/j.toxlet.2024.04.002. Online ahead of print.ABSTRACTMitochondrial fatty acid oxidation (mtFAO) plays an important role in hepatic energy metabolism. Severe mtFAO injury leads to nonalcoholic fatty liver disease (NAFLD) and liver failure. Several drugs have been withdrawn owing to safety issues, such as induction of fatty liver disease through mtFAO disruption. For instance, the antimicrobial triclocarban (TCC), an environmental contaminant that was removed from the market due to its unknown safety in humans, induces NAFLD in rats and promotes hepatic FAO in mice. Therefore,...
Source: Toxicology Letters - April 17, 2024 Category: Toxicology Authors: Hitoshi Nakamura Toshikatsu Matsui Tadahiro Shinozawa Source Type: research
The Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease
Ann Hepatol. 2024 Apr 15:101501. doi: 10.1016/j.aohep.2024.101501. Online ahead of print.ABSTRACTMetabolic Dysfunction-Associated Fatty Liver Disease and Diabetes Mellitus are two prevalent metabolic disorders that often coexist and synergistically contribute to the progression of each other. Several pathophysiological pathways are involved in the association, including insulin resistance, inflammation, and lipotoxicity, providing a foundation for understanding the complex interrelationships between these conditions. The presence of MASLD has a significant impact on diabetes risk and the development of microvascular and ma...
Source: Annals of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Francisco Barrera Javier Uribe Nixa Olvares Paula Huerta Daniel Cabrera Manuel Romero-G ómez Source Type: research
From the Editor ’s Desk...
Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). However, given that MASLD requires at least one cardiometabolic risk factor, questions were raised as to whether new evidence would need to be generated for MASLD. In this issue, Younossi and coworkers compared the clinical profile and outcomes of NAFLD to MASLD using a tertiary-care NAFLD database and NHANES-III. Ninety-nine percent of included patients met MASLD criteria while 95% met MASLD criteria on BMI only. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research
Italian guidelines for the management of adult individuals with overweight and obesity and metabolic comorbidities that are resistant to behavioral treatment
ConclusionThe present GL is directed to all physicians addressing people with obesity —working in hospitals, territorial services or private practice—and to general practitioners and patients. The recommendations should also consider the patient’s preferences and the available resources and expertise. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2024 Category: Endocrinology Source Type: research
Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against non-alcoholic fatty liver disease
CONCLUSIONS: Ursolic acid could improve immune inflammation in NAFLD by modulating SPP1-mediated Th17 cell differentiation via the ERK signaling pathway, which is orchestrated jointly by ITGB1 and CD44, emerging as a linchpin in this molecular cascade.PMID:38623614 | DOI:10.3350/cmh.2024.0047 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Yiyuan Zheng Lina Zhao Zhekun Xiong Chaoyuan Huang Qiuhong Yong Dan Fang Yugang Fu Simin Gu Chong Chen Jiacheng Li Yingying Zhu Jing Liu Fengbin Liu Yong Li Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
Overexpression of Slc22a18 facilitates fat accumulation in mice
Biochem Biophys Res Commun. 2024 Apr 9;712-713:149922. doi: 10.1016/j.bbrc.2024.149922. Online ahead of print.ABSTRACTWe previously reported that solute carrier family 22 member 18 (Slc22a18) regulates lipid accumulation in 3T3-L1 adipocytes. Here, we provide additional evidence derived from experiments with adenoviral vector expression and genetic manipulation of mice. In primary cultured rat hepatocytes, adenoviral overexpression of mouse Slc22a18 increased triglyceride accumulation and triglyceride synthetic activity, which was decreased in an adenoviral knockdown experiment. Adenoviral overexpression of mouse Slc22a18 ...
Source: Biochemical and Biophysical Research communications - April 16, 2024 Category: Biochemistry Authors: Takashi Yamamoto Yoko Iizuka Kozue Izumi-Yamamoto Midori Shirota Nobuko Mori Yoshikazu Tahara Toshiro Fujita Takanari Gotoda Source Type: research
Overexpression of Slc22a18 facilitates fat accumulation in mice
Biochem Biophys Res Commun. 2024 Apr 9;712-713:149922. doi: 10.1016/j.bbrc.2024.149922. Online ahead of print.ABSTRACTWe previously reported that solute carrier family 22 member 18 (Slc22a18) regulates lipid accumulation in 3T3-L1 adipocytes. Here, we provide additional evidence derived from experiments with adenoviral vector expression and genetic manipulation of mice. In primary cultured rat hepatocytes, adenoviral overexpression of mouse Slc22a18 increased triglyceride accumulation and triglyceride synthetic activity, which was decreased in an adenoviral knockdown experiment. Adenoviral overexpression of mouse Slc22a18 ...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Takashi Yamamoto Yoko Iizuka Kozue Izumi-Yamamoto Midori Shirota Nobuko Mori Yoshikazu Tahara Toshiro Fujita Takanari Gotoda Source Type: research
