Adult Laryngeal Pleomorphic Rhabdomyosarcoma: A Rare Entity
Ear Nose Throat J. 2023 Sep 16:1455613231198986. doi: 10.1177/01455613231198986. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is a rare and aggressive cancerous tumor that arises from embryonal mesenchymal cells with skeletal muscle differentiation, and it is exceedingly rare that occurs specifically in the larynx. To date, only 22 instances of laryngeal pleomorphic RMSs have been documented in adults. Consequently, there is limited information available to assist healthcare professionals in effectively handling RMS in the larynx of adult patients. Here, we present an uncommon occurrence involving a 45-year-old man...
Source: Ear, Nose and Throat Journal - September 16, 2023 Category: ENT & OMF Authors: Hua Cai Shan Chen Zhuo-Ya Zhang Bei-Bei Gao Yan-Yan Ding Bang-Hua Liu Wen-Wen Wang Source Type: research
Adult Laryngeal Pleomorphic Rhabdomyosarcoma: A Rare Entity
Ear Nose Throat J. 2023 Sep 16:1455613231198986. doi: 10.1177/01455613231198986. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is a rare and aggressive cancerous tumor that arises from embryonal mesenchymal cells with skeletal muscle differentiation, and it is exceedingly rare that occurs specifically in the larynx. To date, only 22 instances of laryngeal pleomorphic RMSs have been documented in adults. Consequently, there is limited information available to assist healthcare professionals in effectively handling RMS in the larynx of adult patients. Here, we present an uncommon occurrence involving a 45-year-old man...
Source: Ear, Nose and Throat Journal - September 16, 2023 Category: ENT & OMF Authors: Hua Cai Shan Chen Zhuo-Ya Zhang Bei-Bei Gao Yan-Yan Ding Bang-Hua Liu Wen-Wen Wang Source Type: research
Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival
CONCLUSIONS: BARD1 is an important neuroblastoma predisposition gene harboring both common and rare germline P-LP variation. The presence of any germline P-LP variant in a CPG was independently predictive of worse overall survival. As centers move toward paired tumor-normal sequencing at diagnosis, efforts should be made to centralize data and provide an infrastructure to support cooperative longitudinal prospective studies of germline pathogenic variation.PMID:37688579 | DOI:10.1093/jnci/djad183 (Source: Cancer Control)
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Jung Kim Zalman Vaksman Laura E Egolf Rebecca Kaufman J Perry Evans Karina L Conkrite Arnavaz Danesh Gonzalo Lopez Michael P Randall Maiah H Dent Lance M Farra Neil L Menghani Malwina Dymek Heena Desai Ryan Hausler Belynda Hicks Jaime Guidry Auvil Daniela Source Type: research
Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours
ConclusionsGiven the heterogeneity of immune infiltration within pedNST, our findings suggest personalized immunogenomic profiling is needed to guide selection of immunotherapeutic strategies. (Source: Genome Medicine)
Source: Genome Medicine - September 7, 2023 Category: Genetics & Stem Cells Source Type: research
Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Int J Cancer. 2023 Aug 26. doi: 10.1002/ijc.34697. Online ahead of print.ABSTRACTMalignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bloodstream, presumed within extracellular-vesicles (EVs) and represent promising biomarkers. Here, we comprehensively examined the role of EVs, and their miRNA cargo, on (fibroblast/endothelial/macrophage) cells representative of the testicular GCT (...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Luz Alonso-Crisostomo Jennifer Trendell Marta Ferraresso Shivani Bailey Dawn Ward Zachary G L Scurlock Stephanie C Wenlock Carlos A P Bastos Ravin Jugdaohsingh Nuno J Faria Anton J Enright Cinzia G Scarpini Nicholas Coleman Matthew J Murray Source Type: research
Genes, Vol. 14, Pages 1670: Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal Genes
This article aims to provide a comprehensive analysis of three unique cases involving pediatric patients with CPS who were diagnosed with multiple simultaneous or metachronous cancers. The first case involves a child with embryonal rhabdomyosarcoma, nephroblastoma, glioma, and subsequent medulloblastoma. Genetic analysis identified two pathogenic variants in the BRCA2 gene. The second case involves a child with alveolar rhabdomyosarcoma, juvenile xanthogranuloma, gliomas, and subsequent JMML/MDS/MPS. A pathogenic variant in the NF1 gene was identified. The third case involves a child with pleuropulmonary blastoma and pedia...
Source: Genes - August 24, 2023 Category: Genetics & Stem Cells Authors: Gabriela Telman Ewa Strauss Patrycja Sosnowska-Sienkiewicz Magdalena Halasz Danuta Januszkiewicz-Lewandowska Tags: Article Source Type: research
A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma
This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the synergistic potential of histone deacetylase inhibitors. We searched two databases (PubMed and Google Scholar) for the keywords “Rhabdomyosarcoma, histone deacetylase, histone deacetylase inhibitors.” We excluded three publications that did not permit access to the full text to review and those that focus exclusively on pleiomorphic RMS in adults. Forty-seven papers met the i...
Source: Frontiers in Oncology - August 18, 2023 Category: Cancer & Oncology Source Type: research
Case Report: A Role for Genitourinary Reconstruction in Locally Advanced Bilateral Wilm ’s Tumor
Wilm ’s tumor, an embryonal tumor that develops from remnants of the immature kidney, is the most common primary malignant renal tumor of childhood and accounts for approximately 6-7% of all childhood cancers. Here we present a case of a 10-year-old female with Stage IV Wilm’s Tumor involving the bil ateral kidneys. She ultimately required complex genitourinary reconstruction via a transureteroureterostomy following extensive oncologic resection. This case highlights the critical role of Urologists at an early stage in cases requiring complex genitourinary reconstruction. (Source: Urology)
Source: Urology - August 7, 2023 Category: Urology & Nephrology Authors: Andrew Z Carey, Hau Le, Walid A Farhat, Vinaya Bhatia Source Type: research
A Role for Genitourinary Reconstruction in Locally Advanced Bilateral Wilm ’s Tumor
Wilm ’s tumor, an embryonal tumor that develops from remnants of the immature kidney, is the most common primary malignant renal tumor of childhood and accounts for approximately 6%-7% of all childhood cancers. Here, we present a case of a 10-year-old female with stage IV Wilm’s tumor involving the b ilateral kidneys. She ultimately required complex genitourinary reconstruction via a transureteroureterostomy following extensive oncologic resection. This case highlights the critical role of Urologists at an early stage in cases requiring complex genitourinary reconstruction. (Source: Urology)
Source: Urology - August 7, 2023 Category: Urology & Nephrology Authors: Andrew Z. Carey, Hau Le, Walid A. Farhat, Vinaya Bhatia Tags: Pediatric Case Reports Source Type: research
GSE181562 The landscape of circular RNAs in neuroblastoma [V]
Contributors : Steffen Fuchs ; Joerg Fallmann ; Johannes H SchulteSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs (circRNAs), a noncoding RNA class originating from alternative splicing, are highly abundant in neural tissues and were shown to regulate gene expression e.g. by interacting with microRNAs and RNA-binding proteins. Neuroblastoma is an embryonal neoplasia, which arises from undifferentiated neural crest cells. Here, we aimed to explore, whether circRNAs influence the pathogenesis of high-risk neuroblastoma. We performed whole-transcriptome sequencing of 104 ...
Source: GEO: Gene Expression Omnibus - August 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Radiotherapy for rare primary brain tumors
Cancer Radiother. 2023 Jul 20:S1278-3218(23)00121-X. doi: 10.1016/j.canrad.2023.06.008. Online ahead of print.ABSTRACTRare central nervous system tumors are defined by an incidence rate of less than 6 cases per 100 000 individuals a year. It comprises a large panel of entities including medulloblastoma, glioneuronal tumors, solitary fibrous tumors, rare pituitary tumors, ependymal or embryonal tumors. The management of these tumors is not clearly defined and radiotherapy indications should be discussed at a multidisciplinary board. Image-guided and intensity-modulated radiation therapy should be proposed and MRI has a fund...
Source: Cancer Radiotherapie - July 22, 2023 Category: Cancer & Oncology Authors: E Mesny P Lesueur Source Type: research
Radiotherapy for rare primary brain tumors
Cancer Radiother. 2023 Jul 20:S1278-3218(23)00121-X. doi: 10.1016/j.canrad.2023.06.008. Online ahead of print.ABSTRACTRare central nervous system tumors are defined by an incidence rate of less than 6 cases per 100 000 individuals a year. It comprises a large panel of entities including medulloblastoma, glioneuronal tumors, solitary fibrous tumors, rare pituitary tumors, ependymal or embryonal tumors. The management of these tumors is not clearly defined and radiotherapy indications should be discussed at a multidisciplinary board. Image-guided and intensity-modulated radiation therapy should be proposed and MRI has a fund...
Source: Cancer Radiotherapie - July 22, 2023 Category: Cancer & Oncology Authors: E Mesny P Lesueur Source Type: research
Clinicopathological and treatment response characteristics of updated rhabdomyosarcoma histomolecular subtypes: An Asian population-based study
CONCLUSION: Disease and treatment response profiles of rhabdomyosarcoma subtypes vary significantly between adults and children, especially surgical resectability. In our Asian population, poorer outcomes were observed in adults with embryonal and alveolar tumors, while activating mutations influence the behavior of otherwise favorable spindle cell/sclerosing tumors.PMID:37434429 | DOI:10.1111/ajco.13975 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Guo Yuan How Chik Hong Kuick Min Hwee Yong Shui Yen Soh Esther Xy Hee Meng Kang Wong Richard Quek Mohd Farid Harunal Sathiyamoorthy Selvarajan Kesavan Sittampalam Chetan Anil Dhamne Victor Lee Kenneth Te Chang Amos Hp Loh Source Type: research
Clinicopathological and treatment response characteristics of updated rhabdomyosarcoma histomolecular subtypes: An Asian population-based study
CONCLUSION: Disease and treatment response profiles of rhabdomyosarcoma subtypes vary significantly between adults and children, especially surgical resectability. In our Asian population, poorer outcomes were observed in adults with embryonal and alveolar tumors, while activating mutations influence the behavior of otherwise favorable spindle cell/sclerosing tumors.PMID:37434429 | DOI:10.1111/ajco.13975 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Guo Yuan How Chik Hong Kuick Min Hwee Yong Shui Yen Soh Esther Xy Hee Meng Kang Wong Richard Quek Mohd Farid Harunal Sathiyamoorthy Selvarajan Kesavan Sittampalam Chetan Anil Dhamne Victor Lee Kenneth Te Chang Amos Hp Loh Source Type: research
Review: Targeting EZH2 in Neuroblastoma
Neuroblastoma is the most common extra-cranial solid tumor with up to 100 children newly diagnosed annually in the UK [1]. Around 40% of patients are diagnosed before 1 year old and the median age at diagnosis is 17-18 months [2]. Neuroblastoma is an embryonal tumor of the sympathetic nervous system arising from immature neural crest cells [3]. It generally originates in the adrenal glands (65%), however, it can arise from anywhere containing sympathetic nervous tissue, including the chest (20%), neck (5%) and pelvis (5%) [4]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - July 12, 2023 Category: Cancer & Oncology Authors: Jinhui Gao, Claire Fosbrook, Jane Gibson, Timothy Underwood, Juliet Gray, Zo ë Walters Tags: Anti-tumour Treatment Source Type: research
