Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
