Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Staufen1 controls mitochondrial metabolism via HIF2 α in embryonal rhabdomyosarcoma and promotes tumorigenesis
We report the novel and differential role of STAU1 in mitochondrial metabolism in cancerous versus non-malignant skeletal muscle cells (NMSkMCs). Specifically, our data show that STAU1 depletion reduces OXPHOS and inhibits proliferation of ERMS cells. Our findings further reveal the binding of STAU1 to several OXPHOS mRNAs which affects their stability. Indeed, STAU1 depletion reduced the stability of OXPHOS mRNAs, causing inhibition of mitochondrial metabolism. In parallel, STAU1 depletion impacted negatively the HIF2α pathway which further modulates mitochondrial metabolism. Exogenous expression of HIF2α in STAU1-deple...
Source: Cellular and Molecular Life Sciences : CMLS - October 17, 2023 Category: Cytology Authors: Shekoufeh Almasi Sahar SarmastiEmami Stephen Baird Zhibin Ning Daniel Figeys Jocelyn C ôté Kyle N Cowan Bernard J Jasmin Source Type: research
Staufen1 controls mitochondrial metabolism via HIF2 α in embryonal rhabdomyosarcoma and promotes tumorigenesis
We report the novel and differential role of STAU1 in mitochondrial metabolism in cancerous versus non-malignant skeletal muscle cells (NMSkMCs). Specifically, our data show that STAU1 depletion reduces OXPHOS and inhibits proliferation of ERMS cells. Our findings further reveal the binding of STAU1 to several OXPHOS mRNAs which affects their stability. Indeed, STAU1 depletion reduced the stability of OXPHOS mRNAs, causing inhibition of mitochondrial metabolism. In parallel, STAU1 depletion impacted negatively the HIF2α pathway which further modulates mitochondrial metabolism. Exogenous expression of HIF2α in STAU1-deple...
Source: Cellular and Molecular Life Sciences : CMLS - October 17, 2023 Category: Cytology Authors: Shekoufeh Almasi Sahar SarmastiEmami Stephen Baird Zhibin Ning Daniel Figeys Jocelyn C ôté Kyle N Cowan Bernard J Jasmin Source Type: research
Cancers, Vol. 15, Pages 4939: Introduction to the Beckwith & ndash;Wiedemann Syndrome and Cancer Special Issue
Cancers, Vol. 15, Pages 4939: Introduction to the Beckwith–Wiedemann Syndrome and Cancer Special Issue
Cancers doi: 10.3390/cancers15204939
Authors:
Alessandro Mussa
Jennifer M. Kalish
Beckwith–Wiedemann syndrome (BWS) is a genetic imprinting disorder that most commonly presents as overgrowth, macroglossia, abdominal wall defects, lateralized overgrowth, and embryonal tumors [...] (Source: Cancers)
Source: Cancers - October 11, 2023 Category: Cancer & Oncology Authors: Alessandro Mussa Jennifer M. Kalish Tags: Editorial Source Type: research
Comparative Analysis of the Embryonal Brain Tumors Based on Their Molecular Features
Discov Med. 2023 Oct;35(178):733-749. doi: 10.24976/Discov.Med.202335178.69.ABSTRACTPediatric brain tumors currently show the highest incidence among solid childhood malignancies and, together with leukemia, are the leading cause of death from cancer in childhood. Embryonal brain tumors are the most common and frequent type of childhood brain cancer and are usually characterized by an extremely aggressive course of the disease with the worst outcomes in most cases. There is an urgent need for specific refined molecular diagnostics, which would help to develop personalized treatment. In the present review paper, the latest ...
Source: Discovery Medicine - October 9, 2023 Category: Research Authors: Valeriia Shcherbina Larysa Kovalevska Eugene Pedachenko Tetyana Malysheva Elena Kashuba Source Type: research
