< em > NF1 < /em > -Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of < em > NF1 < /em > -Mutant Rhabdomyosarcoma and < em > NF1 < /em > -Associated Malignant Triton Tumor
CONCLUSION: Patients with NF1-mutant ERMS lacking TP53 alterations may benefit from dose-reduction chemotherapy. On the basis of the diagnostic challenges and significant treatment and prognostic differences, molecular profiling of challenging tumors with rhabdomyoblastic differentiation is recommended.PMID:38603649 | DOI:10.1200/PO.23.00597 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Henry de Traux de Wardin Josephine K Dermawan Fabio Vanoli Samuel C Jiang Samuel Singer Ping Chi William Tap Leonard H Wexler Cristina R Antonescu Source Type: research
GSE262587 TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell lineage committment
Contributors : Jeremie Poschmann ; Gilles Salbert ; Martin Braud ; Cynthia Fourgeux ; Thierry Madigou ; Marion TurpinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCell differentiation during development is associated to large-scale modifications in the methylome that require the engagement of an active DNA demethylation machinery including Ten-Eleven-Translocation enzymes for oxidation of 5-methylcytosine and the T:G mismatch DNA glycosylase (TDG) for removal of the oxidized bases. Despite this well-defined molecular function, the biological output of TDG activity remains elus...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Clinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center
CONCLUSIONS: SRCTs have a variable age of presentation. Their incidence in CNS is low as compared to other organ systems. On light microscopy, the histopathology of these lesions is overlapping, posing a great diagnostic dilemma for the pathologist. The use of ancillary techniques like immunohistochemistry helps in arriving at the correct diagnosis. Treatment strategy and tumor prognosis also vary along the entire spectrum of SRCT, thus making exact characterization essential for proper management.PMID:38554327 | DOI:10.4103/jcrt.jcrt_383_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Pooja Gupta Fouzia Siraj K B Shankar Manish Rawat Dipanker S Mankotia Vivek Yadav Amit Dagar Source Type: research
Cancers, Vol. 16, Pages 1343: Differential Competitive Growth of Transgenic Subclones of Neuroblastoma Cells Expressing Different Levels of Cathepsin D Co-Cultured in 2D and 3D in Response to EGF: Implications in Tumor Heterogeneity and Metastasis
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Ciro Isidoro
Neuroblastoma (NB) is an embryonal tumor arising from the sympathetic central nervous system. The epidermal growth factor (EGF) plays a role in NB growth and metastatic behavior. Recently, we have demonstrated that cathepsin D (CD) contrasts EGF-induced NB cell growth in 2D by downregulating EGFR/MAPK signaling. Aggressive NB is highly metastatic to the bone and the brain. In the metastatic process, adherent cells detach to form clusters of suspended cells that adhere once they reach the metastatic site and form secondary colonies. Whether CD is involved in the survival of metastatic NB clones is not ...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Eleonora Secomandi Andrea Esposito Giulia Camurani Chiara Vidoni Amreen Salwa Chiara Lualdi Letizia Vallino Alessandra Ferraresi Ciro Isidoro Tags: Article Source Type: research
Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives
Transcription. 2024 Mar 28:1-20. doi: 10.1080/21541264.2024.2334106. Online ahead of print.ABSTRACTAryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell prol...
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Ji řina Procházková Zuzana Kahounov á Jan Vondr áček Karel Sou ček Source Type: research
GSE261811 T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets
In this study, we found that T cells including Treg and Tfh were most abundant in seminoma compared to mixed tumors and embryonal carcinoma. Taken together, despite significant heterogeneity between patients, this study demonstrated that T cell subtypes form a key component of the TGCT microenvironment. The novel finding of rare Treg and Tfh cells in the human testis suggests their involvement in TGCT pathobiology, with implications for understanding tumor progression, assessing patient prognosis, and as putative targets for personalized immunotherapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Role of Alpha-Fetoprotein in the Pathogenesis of Cancer
J Environ Pathol Toxicol Oncol. 2024;43(2):57-76. doi: 10.1615/JEnvironPatholToxicolOncol.2023049145.ABSTRACTAlpha-fetoprotein (AFP) belongs to the albuminoid protein family and is considered as the fetal analog of serum albumin. This plasma protein is initially synthesized in the fetal liver and yolk sac and shows a maximum peak near the end of the first trimester. Later, concentrations begin to decline prenatally and drop precipitously after birth. This protein has three key ligand-binding pockets for interactions with various biomolecules. It contains multiple phosphorylation and acetylation sites for the regulation of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Alok Ghosh Chaudhuri Saptadip Samanta Monalisha Dey N S Raviraja Souvik Dey Source Type: research
