Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Med Mol Morphol. 2023 Nov 22. doi: 10.1007/s00795-023-00374-9. Online ahead of print.ABSTRACTSerpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely c...
Source: Molecular Medicine - November 22, 2023 Category: Molecular Biology Authors: Toshiki Anami Yuki Ibe Lianbo Li Yoshihiro Komohara Hiroki Hirao Mamoru Harada Hiromu Yano Yukio Fujiwara Takanobu Motoshima Junji Yatsuda Taizo Hibi Tomomi Kamba Source Type: research
Overexpression of SerpinB9 in non-seminomatous germ cell tumors
AbstractSerpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely correlated with the number of tumor-infiltrating CD8-positive cells. In addition, yolk...
Source: Medical Molecular Morphology - November 22, 2023 Category: Molecular Biology Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Mol Biol Cell - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Mol Biol Cell - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
Microscopic Analysis of Heterochromatin, Euchromatin and Cohesin in Cancer Cell Models and under Anti-Cancer Treatment
Curr Issues Mol Biol. 2023 Oct 9;45(10):8152-8172. doi: 10.3390/cimb45100515.ABSTRACTThe spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for a cell type since it is involved in a TAD (topologically associating domain) formation, and thus in gene regulation or DNA repair processes. Based on the previous hypotheses and results on the general importance of heterochromatin organization on genome functions in particular, the configuratio...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Elias Ferdinand Fischer G ötz Pilarczyk Michael Hausmann Source Type: research
