Spontaneous rupture ‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations
Oncol Lett. 2024 Feb 28;27(4):183. doi: 10.3892/ol.2024.14316. eCollection 2024 Apr.ABSTRACTSpontaneous rupture and hemorrhage of mediastinal germ cell tumors is a rare occurrence. In the current report, the case of a 20-year-old male patient who was admitted with chest tightness and dyspnea is presented. An urgent chest CT scan revealed a large tumor in the right anterior mediastinum, measuring ~12 cm in diameter, with associated intratumoral hemorrhage. An emergency thoracotomy was performed to excise the lesion, which revealed that the bleeding was caused by a ruptured tumor. Postoperative pathological findings revealed...
Source: Oncology Letters - March 13, 2024 Category: Cancer & Oncology Authors: Xiaosong Li Shenghan Xu Yunbin Li Yanping Tang Kaiying Wang Yumeng Lei Jian Ma Jian Li Source Type: research
ESTRO-SIOPE guideline: Clinical management of radiotherapy in atypical teratoid/rhabdoid tumors (AT/RTs)
Atypical teratoid/rhabdoid tumors (AT/RT) are tumors of the central nervous system (CNS) most commonly diagnosed in very young children [1 –5], with most (70–80 %) tumors found in children under three years of age [6,7]. The German Childhood Cancer Registry reported that the median age at diagnoses was 18 months [8]. These rare embryonal tumors are locally aggressive and one of the most malignant CNS tumors. Also, they spread t hroughout the CNS by cerebrospinal fluid (CSF). Up to one-third of the patients have disseminated disease in the brain or spinal canal or both at diagnosis [9,10]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 13, 2024 Category: Radiology Authors: Beate Timmermann, Claire Alapetite, Karin Dieckmann, Rolf-Dieter Kortmann, Yasmin Lassen-Ramshad, John H. Maduro, Monica Ramos Albiac, Umberto Ricardi, Damien C. Weber Tags: Original Article Source Type: research
Cancers, Vol. 16, Pages 897: Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children
Han-Ping Wu
Undifferentiated embryonal sarcoma of the liver is a rare mesenchymal tumor with a highly malignant potential. It occurs almost exclusively in the pediatric population and typically has a poor outcome. Although previous studies have reported dismal prognoses, recent advances in combined treatment modalities, e.g., surgery and chemotherapy, have given cause for optimism. Even in those diseases not amenable to complete surgical resection or refractory diseases, other treatment modalities, such as liver transplant, have yielded promising results. This paper provides a review of the current treatment modaliti...
Source: Cancers - February 23, 2024 Category: Cancer & Oncology Authors: Wen-Ya Lin Kang-Hsi Wu Chun-Yu Chen Bei-Cyuan Guo Yu-Jun Chang Mao-Jen Lin Han-Ping Wu Tags: Review Source Type: research
EHMT2/G9a and EZH2: Epimarkers in testicular germ cell tumors
Discussion and conclusionOverall, our data suggest that EZH2 and EHMT2/G9a might be associated with greater aggressiveness and, eventually, involved in the metastatic setting, paving the way for testing targeted therapies. (Source: Andrology)
Source: Andrology - February 22, 2024 Category: Urology & Nephrology Authors: Helena Estev ão‐Pereira,
Catarina Guimarães‐Teixeira,
Bianca C. T. Flores,
Filipa Moreira‐Silva,
Nuno Tiago Tavares,
Rita Guimarães,
Isaac Braga,
Joaquina Maurício,
Rui Henrique,
Carmen Jerónimo,
João Lobo Tags: ORIGINAL ARTICLE Source Type: research
Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adolescents and young adults with recurrent/refractory solid tumors from the MOSCATO-01 and MAPPYACTS trials, using normal and tumor whole exome and RNA sequencing data and benchmarked algorithms. There was no evidence for narrowed HLA allelic diversity but discordant homozygosity and allele frequencies across tumor types and subtypes, such as in embryonal and alveolar rhabdomyosar...
Source: Frontiers in Immunology - January 22, 2024 Category: Allergy & Immunology Source Type: research
Cancers, Vol. 16, Pages 232: Rare Pediatric Cerebellar High-Grade Gliomas Mimic Medulloblastomas Histologically and Transcriptomically and Show p53 Mutations
In this study, we described the histological and molecular features of a series of five pediatric high-grade gliomas of the cerebellum. They actually showed histological and immunohistochemical features that overlapped with those of medulloblastomas and achieved high scores in NanoString-based medulloblastoma diagnostic assay. Methylation profiling demonstrated these tumors were heterogeneous epigenetically, clustering to GBM_MID, DMG_K27, and GBM_RTKIII methylation classes. MYCN amplification was present in one case, and PDGFRA amplification in another two cases. Interestingly, target sequencing showed that all tumors car...
Source: Cancers - January 4, 2024 Category: Cancer & Oncology Authors: Zhi-Feng Shi Kay Ka-Wai Li Anthony Pak-Yin Liu Nellie Yuk-Fei Chung Chit Chow Hong Chen Nim-Chi Amanda Kan Xian-Lun Zhu Danny Tat-Ming Chan Ying Mao Ho-Keung Ng Tags: Article Source Type: research
Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum
In conclusion, excessively increased hCG serum levels can appear in patients with pure SEM. To explain detectable hCG serum levels, it is important to diagnose the subtype of a SEM with syncytiotrophoblasts. (Source: Virchows Archiv)
Source: Virchows Archiv - December 14, 2023 Category: Pathology Source Type: research
Activation of estrogen receptor induces differential proteomic responses mainly involving migration, invasion, and tumor development pathways in human testicular embryonal carcinoma NT2/D1 cells
J Steroid Biochem Mol Biol. 2023 Dec 11:106443. doi: 10.1016/j.jsbmb.2023.106443. Online ahead of print.ABSTRACTThe aims of the present study were to investigate the global changes on proteome of human testicular embryonal carcinoma NT2/D1 cells treated with 17β-estradiol (E2), and the effects of this hormone on migration, invasion, and colony formation of these cells. A quantitative proteomic analysis identified the presence of 1230 proteins in both E2-treated and control cells. The analysis revealed 75 differentially abundant proteins (DAPs), out of which 43 proteins displayed a higher abundance and, 30 proteins showed ...
Source: Mol Biol Cell - December 13, 2023 Category: Molecular Biology Authors: Carla Macheroni Giuseppe Gianini Figueir êdo Leite Deborah Sim ão Souza Carolina Meloni Vicente Jos é Thalles Lacerda Maria Nath ália de Carvalho Magalhães Moraes Maria Aparecida Juliano Catarina Segreti Porto Source Type: research
Activation of estrogen receptor induces differential proteomic responses mainly involving migration, invasion, and tumor development pathways in human testicular embryonal carcinoma NT2/D1 cells
J Steroid Biochem Mol Biol. 2023 Dec 11:106443. doi: 10.1016/j.jsbmb.2023.106443. Online ahead of print.ABSTRACTThe aims of the present study were to investigate the global changes on proteome of human testicular embryonal carcinoma NT2/D1 cells treated with 17β-estradiol (E2), and the effects of this hormone on migration, invasion, and colony formation of these cells. A quantitative proteomic analysis identified the presence of 1230 proteins in both E2-treated and control cells. The analysis revealed 75 differentially abundant proteins (DAPs), out of which 43 proteins displayed a higher abundance and, 30 proteins showed ...
Source: Mol Biol Cell - December 13, 2023 Category: Molecular Biology Authors: Carla Macheroni Giuseppe Gianini Figueir êdo Leite Deborah Sim ão Souza Carolina Meloni Vicente Jos é Thalles Lacerda Maria Nath ália de Carvalho Magalhães Moraes Maria Aparecida Juliano Catarina Segreti Porto Source Type: research
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
This study identified a nanobody-drug-conjugate targeting CXCR4 as a putative therapeutic option for GCT, i.e. seminoma and yolk-sac tumors. Furthermore, this study shed light on the functional role of the CXCR4 / CXCR7 / CXCL12-signaling cascade in GCT, demonstrating an import ant influence on proliferation and migration. (Source: Experimental Hematology and Oncology)
Source: Experimental Hematology and Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research
Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Med Mol Morphol. 2023 Nov 22. doi: 10.1007/s00795-023-00374-9. Online ahead of print.ABSTRACTSerpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely c...
Source: Molecular Medicine - November 22, 2023 Category: Molecular Biology Authors: Toshiki Anami Yuki Ibe Lianbo Li Yoshihiro Komohara Hiroki Hirao Mamoru Harada Hiromu Yano Yukio Fujiwara Takanobu Motoshima Junji Yatsuda Taizo Hibi Tomomi Kamba Source Type: research
