Molecular characterization of the CXCR4  / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates

This study identified a nanobody-drug-conjugate targeting CXCR4 as a putative therapeutic option for GCT, i.e. seminoma and yolk-sac tumors. Furthermore, this study shed light on the functional role of the CXCR4 / CXCR7 / CXCL12-signaling cascade in GCT, demonstrating an import ant influence on proliferation and migration.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research