Embryonal precursors of Wilms tumor
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hyper...
Source: ScienceNOW - December 4, 2019 Category: Science Authors: Coorens, T. H. H., Treger, T. D., Al-Saadi, R., Moore, L., Tran, M. G. B., Mitchell, T. J., Tugnait, S., Thevanesan, C., Young, M. D., Oliver, T. R. W., Oostveen, M., Collord, G., Tarpey, P. S., Cagan, A., Hooks, Y., Brougham, M., Reynolds, B. C., Barone, Tags: Development, Medicine, Diseases reports Source Type: news

Judge cancels court-ordered cancer surgery for girl, 13, after mom tried to treat her with CBD oil
An Oregon court canceled a surgery the state had ordered for Kylee Dixon, 13, of Wilsonville, to treat a rare liver cancer, undifferentiated embryonal sarcoma, which she was diagnosed with in 2018. (Source: the Mail online | Health)
Source: the Mail online | Health - September 27, 2019 Category: Consumer Health News Source Type: news

UCLA scientists use stem cells to study genetics of germ cell tumors
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology and a ...
Source: UCLA Newsroom: Health Sciences - January 29, 2018 Category: Universities & Medical Training Source Type: news

A way to target the Achilles heel of neuroblastoma
(Children's Cancer Institute Australia) Australian scientists have identified a critical molecular 'feedback loop' that helps initiate and drive neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells. The research team have also identified an experimental drug, currently in clinical trials for adult cancer, with the potential to interrupt the loop and halt tumor progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 4, 2015 Category: Cancer & Oncology Source Type: news

'Breakthrough' may lead to new treatment for fatal childhood cancer
Scientists have discovered an enzyme in the "developmental pathway" of patients with embryonal tumors within multilayers rosettes - an uncommon but deadly childhood brain cancer - which they say may lead to more effective treatment of the disease.The study, published in the journal Nature Genetics, was led by researchers from the Research Institute of the McGill University Health Centre (RI-MUHC), the McGill University and Génome Québec Innovation Centre and The Hospital for Sick Children (SickKids) in Canada. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 17, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

N-cadherin Expression in Germ Cell Tumors of the TestisN-cadherin Expression in Germ Cell Tumors of the Testis
Expression of the transmembrane protein N-cadherin may be useful to differentiate embryonal and chorionic carcinomas from other histological subtypes of testicular germ cell tumors. BMC Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 18, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news