Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature
CONCLUSION: PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder neck. Further prostate biopsies may aid in proper PSP diagnosis. Cisplatin-based chemotherapy is still the main primary therapy for PSP.PMID:37122514 | PMC:PMC10131029 | DOI:10.12998/wjcc.v11.i10.2267 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Zhi-Lie Cao Bi-Jun Lian Wei-Ying Chen Xu-Dong Fang Hang-Yang Jin Ke Zhang Xiao-Ping Qi Source Type: research
Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature
CONCLUSION: PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder neck. Further prostate biopsies may aid in proper PSP diagnosis. Cisplatin-based chemotherapy is still the main primary therapy for PSP.PMID:37122514 | PMC:PMC10131029 | DOI:10.12998/wjcc.v11.i10.2267 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Zhi-Lie Cao Bi-Jun Lian Wei-Ying Chen Xu-Dong Fang Hang-Yang Jin Ke Zhang Xiao-Ping Qi Source Type: research
Cancers, Vol. 15, Pages 2548: Occurrence of Hepatoblastomas in Patients with Beckwith & ndash;Wiedemann Spectrum (BWSp)
Cancers, Vol. 15, Pages 2548: Occurrence of Hepatoblastomas in Patients with Beckwith–Wiedemann Spectrum (BWSp)
Cancers doi: 10.3390/cancers15092548
Authors:
Steven D. Klein
Madison DeMarchis
Rebecca L. Linn
Suzanne P. MacFarland
Jennifer M. Kalish
Patients with Beckwith–Wiedemann syndrome (BWS), an epigenetic imprinting disorder involving alterations in genes at the 11p15 chromosomal location, are predisposed to develop hepatoblastomas (HBs), which are rare embryonal liver tumors. Tumors can develop after a BWS diagnosis or, conversely, can be the presenting feature leading to a sub...
Source: Cancers - April 29, 2023 Category: Cancer & Oncology Authors: Steven D. Klein Madison DeMarchis Rebecca L. Linn Suzanne P. MacFarland Jennifer M. Kalish Tags: Article Source Type: research
Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis
CONCLUSIONS: Our population-based evidence showed that MMGCT had worse prognosis in older children and adolescents. Choriocarcinomas and embryonal carcinomas had the worst prognosis. Surgery can prolong survival time. Chemotherapy and radiotherapy were not associated with improved prognosis.PMID:37062232 | DOI:10.1016/j.jss.2023.03.018 (Source: Cell Research)
Source: Cell Research - April 16, 2023 Category: Cytology Authors: Peng Wu Yicheng Yang Zhechen Yu Lingling Zhao Shaoguang Feng Source Type: research
Alveolar rhabdomyosarcoma has superior response rates to vinorelbine compared to embryonal rhabdomyosarcoma in patients with relapsed/refractory disease: A meta ‐analysis
ConclusionThese data support further investigation of vinorelbine in newly diagnosed patients with RMS particularly those with alveolar histology. (Source: Cancer Medicine)
Source: Cancer Medicine - April 5, 2023 Category: Cancer & Oncology Authors: Wendy Allen ‐Rhoades,
Philip J. Lupo,
Michael E. Scheurer,
Yueh‐Yun Chi,
John F. Kuttesch,
Rajkumar Venkatramani,
William H. Meyer,
Leo Mascarenhas Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 15, Pages 2144: Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification
ddy
Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions in neuroblastoma, ret...
Source: Cancers - April 4, 2023 Category: Cancer & Oncology Authors: Jyotirmayee Talapatra Mamatha M. Reddy Tags: Review Source Type: research
Cancers, Vol. 15, Pages 1972: Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
andvik
Emma Tham
Medulloblastoma is a malignant embryonal tumor of the central nervous system (CNS) that mainly affects infants and children. Prognosis is highly variable, and molecular biomarkers for measurable residual disease (MRD) detection are lacking. Analysis of cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) using broad genomic approaches, such as low-coverage whole-genome sequencing, has shown promising prognostic value. However, more sensitive methods are needed for MRD analysis. Here, we show the technical feasibility of capturing medulloblastoma-associated structural variants and point mutations simult...
Source: Cancers - March 25, 2023 Category: Cancer & Oncology Authors: Cecilia Arthur Cecilia Jylh ä Teresita D íaz de Ståhl Alia Shamikh Johanna Sandgren Richard Rosenquist Magnus Nordenskj öld Arja Harila Gisela Barbany Ulrika Sandvik Emma Tham Tags: Article Source Type: research
Cancers, Vol. 15, Pages 1872: Investigation of 11p15.5 Methylation Defects Associated with Beckwith-Wiedemann Spectrum and Embriyonic Tumor Risk in Lateralized Overgrowth Patients
Hilmi Apak
The Beckwith–Wiedemann spectrum (BWSp) ranges from isolated lateralized overgrowth (ILO) to classic phenotypes. In this broad clinical spectrum, an epigenetic alteration on chromosome 11p15.5 can be detected. The risk for embryonal tumors is high, especially in patients with lateralized overgrowth (LO). The aim of this study is to investigate epigenetic alterations in 11p15.5 and tumor risk in 87 children with LO. The methylation level of 11p15.5 was examined in the blood of all patients and in skin samples or buccal swabs from 40 patients with negative blood tests; 63.2% of patients were co...
Source: Cancers - March 21, 2023 Category: Cancer & Oncology Authors: Beyhan T üysüz Serdar Bozlak Dilek Uluda ğ Alkaya S üheyla Ocak B üşra Kasap Evrim Sunamak Çifçi Ali Seker Ilhan Avni Bayhan Hilmi Apak Tags: Article Source Type: research
Mortality trends in primary malignant brain and central nervous system tumors vary by histopathology, age, race, and sex
ConclusionExamining age, race, sex, and histopathology-specific mortality trends at the population level can provide important information for clinicians, researchers, and aid in public health planning. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 16, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 1644: Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma
ey
Joanna L. Selfe
Major progress in recent decades has furthered our clinical and biological understanding of rhabdomyosarcoma (RMS) with improved stratification for treatment based on risk factors. Clinical risk factors alone were used to stratify patients for treatment in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 protocol. The current EpSSG overarching study for children and adults with frontline and relapsed rhabdomyosarcoma (FaR-RMS NCT04625907) includes FOXO1 fusion gene status in place of histology as a risk factor. Additional molecular features of significance have recently been ...
Source: Cancers - March 7, 2023 Category: Cancer & Oncology Authors: Daniela Di Di Carlo Julia Chisholm Anna Kelsey Rita Alaggio Gianni Bisogno Veronique Minard-Colin Meriel Jenney Raquel D ávila Fajardo Johannes H. M. Merks Janet M. Shipley Joanna L. Selfe Tags: Review Source Type: research
A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis
Nat Cell Biol. 2023 Feb 27. doi: 10.1038/s41556-023-01093-0. Online ahead of print.ABSTRACTHow abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains elusive. Here we uncover a neurodevelopmental epigenomic programme that is hijacked to induce MB metastatic dissemination. Unsupervised analyses of integrated publicly available datasets with our newly generated data reveal that SMARCD3 (also known as BAF60C) regulates Disabled 1 (DAB1)-mediated Reelin signalling in Purkinje cell migration and MB metastasis by orchestrating cis-regulatory eleme...
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Han Zou Bradley Poore Emily E Brown Jieqi Qian Bin Xie Evridiki Asimakidou Vladislav Razskazovskiy Deanna Ayrapetian Vaibhav Sharma Shunjin Xia Fei Liu Apeng Chen Yongchang Guan Zhengwei Li Siyi Wanggou Olivier Saulnier Michelle Ly Wendy Fellows-Mayle Gui Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
This study describes a new model of embryonal rhabdomyosarcoma driven by the loss of Nf1 and Ink4a/Arf, two mutations commonly found in patient tumors. We find that this new model is histologically similar to other previously-published rhabdomyosarcoma models, although it substantially differs in the time required for tumor onset and in tumor growth kinetics. We also observe unique sex-dependent phenotypes in both primary and newly-developed orthotopic syngeneic allograft tumors that are not present in previous models. Using in vitro and in vivo studies, we examined the response to vincristine, a component of the standard-...
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Wade R Gutierrez Jeffrey D Rytlewski Amanda Scherer Grace A Roughton Nina C Carnevale Krisha Y Vyas Gavin R McGivney Qierra R Brockman Vickie Knepper-Adrian Rebecca D Dodd Source Type: research
