Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?
AbstractDysbiosis corresponds to the disruption of a formerly stable, functionally complete microbiota. In the gut, this imbalance can lead to adverse health outcomes in both the short and long terms, with a potential increase in the lifetime risks of various noncommunicable diseases and disorders such as atopy (like asthma), inflammatory bowel disease, neurological disorders, and even behavioural and psychological disorders. Although antibiotics are highly effective in reducing morbidity and mortality in infectious diseases, antibiotic-associated diarrhoea is a common, non-negligible clinical sign of gut dysbiosis (and th...
Source: Advances in Therapy - January 30, 2024 Category: Drugs & Pharmacology Source Type: research
Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review
In conclusion, the pharmacological potential of Bauhinia plants show promise with various leads such as insulin-like protein, roseoside, bauhiniastatin, and melibiose binding lectin. However, further investigations are required to address existing gaps and advance them towards product development. This review will lay the groundwork for future research initiatives aimed at fully realizing the therapeutic potential of Bauhinia plants.PMID:38286316 | DOI:10.1016/j.fitote.2024.105830 (Source: Fitoterapia)
Source: Fitoterapia - January 29, 2024 Category: Biochemistry Authors: Divya Gudavalli Komal Pandey Venkata Gopal Ede Dakshata Sable Ashwini S Ghagare Abhijeet S Kate Source Type: research
Quality of Life in Locally Advanced Carcinoma Rectum Patients During Various Phases of NACRT: An Indian Perspective
AbstractIn low- and middle-income countries (LMICs) including India, cancer patients have a poor prognosis because of late diagnosis and cases already grown to advanced stages, low cancer awareness and skewed cancer care facilities. In India, the incidence of colorectal cancer (CRC) is ranked the 4th most common (6.4%) in males and the 5th most common (3.4%) in females. The improvement in the cure rate of rectal cancer has increased life expectancy, and assessment of the quality of life (QoL) in these patients has become a fundamental requirement. Little is known about how the patients perceive these adverse effects during...
Source: Indian Journal of Surgical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research
High frequency of antimicrobial resistance in Salmonella and Escherichia coli causing diarrheal diseases at the Yirimadio community health facility, Mali
Diarrhoea is a public health problem, especially in developing countries where it is the second leading cause of child mortality. In Low Income Countries like in Mali, self-medication and inappropriate use of ... (Source: BMC Microbiology)
Source: BMC Microbiology - January 23, 2024 Category: Microbiology Authors: Bintou Diarra, Ibr éhima Guindo, Boī Koné, Maīmouna Dembélé, Ibrahim Cissé, Souleymane Thiam, Kadidia Konaté, Mamadou Tékété, Almoustapha Maīga, Oumou Maīga, Lassina Timbiné and Abdoulaye Djimde Tags: Research Source Type: research
Xylitol for the prevention of acute otitis media episodes in children aged 1-5 years: a randomised controlled trial
Conclusions
Regular use of xylitol did not prevent AOM, URTIs or dental caries in a trial with limited statistical power. A post-hoc analysis indicated that URTIs were less common with xylitol exposure during the COVID-19 pandemic, but this finding could be spurious.
Trial registration number
NCT03055091. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Persaud, N., Azarpazhooh, A., Keown-Stoneman, C., Birken, C. S., Isaranuwatchai, W., Maguire, J. L., Mamdani, M., Allen, C., Mason, D., Kowal, C., Jaleel, M., Bazeghi, F., Thorpe, K. E., Laupacis, A., Parkin, P. C. Tags: Open access Original research Source Type: research
Epidemiology of group A rotavirus in children under five years of age with gastroenteritis in N ’Djamena, Chad
Group A Rotaviruses (RVA) is one of the most common causes of severe diarrhoea in infants and children under 5 years of age. Unlike many countries in the world where RVA surveillance/control is active, in Chad... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 22, 2024 Category: Infectious Diseases Authors: Bertrand Djikoloum, Mahamat Fayiz Abakar, Valentine Ngum Ndze, Rahinatou Ghapoutsa Nkandi, Carine Ngah Enjeh, Pidou Kimala, Jean Paul Assam Assam and Maurice BODA Tags: Research Source Type: research
Risk factors for moderate acute malnutrition among children with acute diarrhoea in India and Tanzania: a secondary analysis of data from a randomized trial
Moderate acute malnutrition (MAM) affects over 30 million children aged (Source: BMC Pediatrics)
Source: BMC Pediatrics - January 19, 2024 Category: Pediatrics Authors: Rodrick Kisenge, Usha Dhingra, Chris A. Rees, Enju Liu, Arup Dutta, Deb Saikat, Pratibha Dhingra, Sarah Somji, Chris Sudfeld, Jon Simon, Per Ashorn, Sunil Sazawal, Christopher P. Duggan and Karim Manji Tags: Research Source Type: research
A comparison between the adverse event profiles of patients receiving palbociclib and abemaciclib: analysis of two real-world databases
ConclusionThis study is the first to show comprehensively the disparities in the AE profiles of palbociclib and abemaciclib. The findings highlight the importance of considering these differences when selecting a suitable CDK4/6 inhibitor to ensure safe and favourable outcomes for patients with breast cancer. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Population pharmacokinetics of posaconazole in allogeneic haematopoietic stem cell transplant patients
ConclusionsIncreased doses of posaconazole should be considered for both prophylaxis and treatment of IFD to increase the proportion of alloHCT patients achieving therapeutic exposures, particularly the oral formulation in patients with mucositis and/or diarrhoea. Posaconazole therapeutic drug monitoring should be considered for all formulations in this setting. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - January 13, 2024 Category: Microbiology Source Type: research
Infections diagnosed in children and young people screened for malaria in UK emergency departments: a retrospective multi-centre study
CONCLUSION: A fifth of CYP presenting to participating UK EDs with fever and a history of travel to a malaria-endemic area and who were screened for malaria had a tropical infection if diarrhoea is included. A third of CYP had no diagnosis. CYP arriving from sub-Saharan Africa had the greatest risk of malaria.Abbreviations: CYP: children and young people; ED: emergency department; PERUKI: Paediatric Emergency Research in the UK and Ireland; RDT: rapid diagnostic test; VFR: visiting friends and relatives.PMID:38212934 | DOI:10.1080/20469047.2023.2299576 (Source: Paediatrics and international child health)
Source: Paediatrics and international child health - January 12, 2024 Category: Pediatrics Authors: Chris Bird Gail N Hayward Philip J Turner Desha Wasala Vanessa Merrick Mark D Lyttle Niall Mullen Thomas R Fanshawe for Paediatric Emergency Research in the UK and Ireland (PERUKI) Source Type: research
Is the impact of paid maternity leave policy on the prevalence of childhood diarrhoea mediated by breastfeeding duration? A causal mediation analysis using quasi-experimental evidence from 38 low-income and middle-income countries
Conclusion
Extending the duration of paid maternity leave appears to lower diarrhoea prevalence in children under 5 years of age in LMICs. This effect is slightly mediated by changes in breastfeeding duration. (Source: BMJ Open)
Source: BMJ Open - January 12, 2024 Category: General Medicine Authors: Chai, Y., Nandi, A., Heymann, J. Tags: Open access, Epidemiology Source Type: research
Oral killed cholera vaccines for preventing cholera
CONCLUSIONS: Two doses of Dukoral reduces cases of cholera at two-year follow-up. Two doses of Shanchol reduces cases of cholera at five-year follow-up, and a single dose of Shanchol reduces cases of cholera at two-year follow-up. Overall, the vaccines were safe and well-tolerated. We found no trials on other BivWC vaccines (Euvichol/Euvichol-Plus). However, BivWC products (Shanchol, Euvichol/Euvichol-Plus) are considered to produce comparable vibriocidal responses. Therefore, it is reasonable to apply the results from Shanchol trials to the other BivWC products (Euvichol/Euvichol-Plus).PMID:38197546 | PMC:PMC10777452 | DO...
Source: Cochrane Database of Systematic Reviews - January 10, 2024 Category: General Medicine Authors: K M Saif-Ur-Rahman Razib Mamun Md Hasan James E Meiring Md Arifuzzaman Khan Source Type: research
Prevalence of Cryptosporidium and Giardia infections in under-five children with diarrhoea in Blantyre, Malawi
Diarrhoeal diseases are common among children in low- and middle-income countries and are major causes of morbidity and mortality. Cryptosporidium and Giardia are considered to be the main parasitic causes of dia... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 9, 2024 Category: Infectious Diseases Authors: Joseph E. V. Bitilinyu-Bangoh, Samra Riesebosch, Marije Rebel, Paul Chiwaya, Sjoerd P. Verschoor, Wieger P. Voskuijl and Henk D. F. H. Schallig Tags: Research Source Type: research
Prevalence of intestinal parasites in HIV/AIDS-infected patients with correlation to CD4+ T-cell count at hospital in Eastern India
CONCLUSIONS: This study has shed light that low CD4+ T-cell count appears to be a factor for intestinal parasitic infections and development of diarrhoea. Regular screening and treatment of intestinal parasitic infections is very important in overall improvement in quality of life of HIV/AIDS patients. Nevertheless, sanitary hygiene practices and deworming are needed to enhance the control of infection in the affected areas.PMID:38186830 | PMC:PMC10771173 | DOI:10.4103/jfmpc.jfmpc_806_23 (Source: Primary Care)
Source: Primary Care - January 8, 2024 Category: Primary Care Authors: Kumari Seema Abhay Kumar Manju Boipai Manoj Kumar Ashok Kumar Sharma Source Type: research
