Defining predictors of responsiveness to advanced therapies in Crohns disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Introduction
Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients.
Current understanding of IBD pathogenesis implicates complex interactions between host genetics and the gut microbiome. Most cohorts s...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Wyatt, N. J., Watson, H., Anderson, C. A., Kennedy, N. A., Raine, T., Ahmad, T., Allerton, D., Bardgett, M., Clark, E., Clewes, D., Cotobal Martin, C., Doona, M., Doyle, J. A., Frith, K., Hancock, H. C., Hart, A. L., Hildreth, V., Irving, P. M., Iqbal, S. Tags: Open access, Gastroenterology and hepatology Source Type: research
Diarrhea and HIV infection
Med Mal Infect. 2003 Feb 1;33:105-110. doi: 10.1016/S0399-077X(02)00479-1. Epub 2003 Feb 19.ABSTRACTThe development of Highly Active Antiretroviral Therapies and of protease inhibitors in particular has permitted in the last ten years to dramatically improve the viral replication in HIV infected patients but the incidence of side effects and of diarrhoea in particular remains high. In general practice, the occurrence of diarrhoea should systematically lead to eliminate an infectious ætiology of diarrhoea. Many studies have demonstrated that diarrhoea under protease inhibitors and nelfinavir in particular are of a low grad...
Source: Medecine et Maladies Infectieuses - April 15, 2024 Category: Infectious Diseases Authors: P Dellamonica Source Type: research
Heterotopic Pancreas: Unusual Cause of Usual Diarrhoea
AbstractHeterotopic pancreas (HP) also known as ectopic pancreas, pancreatic crest or accessory pancreas is the normal pancreatic tissue, found in a remote area other than its natural location, with no anatomic or vascular connection to main pancreatic tissue. It is a rare congenital anomaly and has been reported at many locations such as stomach (antrum) and small intestine. HP is usually an incidental finding and asymptomatic, however there are reports of pancreatitis, obstruction, perforation and malignant transformation as uncommon manifestations. Diagnosis of HP is primarily based on histological examination either by...
Source: Indian Journal of Surgical Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research
Impact of Colorectal Nurse Specialist supervised parental administration of rectal washouts on Hirschsprung ’s disease outcomes: a retrospective review
ConclusionOur stoma rates are lower compared to recent UK data. This could potentially be due to emphasis on parental ability to perform effective rectal washouts at home under CNS supervision. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 13, 2024 Category: Surgery Source Type: research
Prolonged arthralgias in Whipple's disease - A common but often overlooked symptom of a rare disease
We report the case of a middle-aged man admitted for etiologic investigation of prolonged, migrating, and inflammatory arthralgias and subsequent development of gastrointestinal symptoms. Despite its reputation as a great mimicker of many different illnesses, the difficulty in diagnosis probably lies with its rarity rather than its masking.PMID:38606805 | DOI:10.1177/14782715241237283 (Source: Journal of the Royal College of Physicians of Edinburgh)
Source: Journal of the Royal College of Physicians of Edinburgh - April 12, 2024 Category: General Medicine Authors: Bernardo Tourais Canh ão Andr é Trigo Joana In ês Madeira Ad élia Simão Jo ão Madaleno Source Type: research
Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer (CheckMate 358): a phase 1-2, open-label, multicohort trial
This study is registered with ClinicalTrials.gov (NCT02488759) and is now completed.FINDINGS: Between October, 2015, and March, 2020, 193 patients were recruited in the recurrent or metastatic cervical cancer cohort of CheckMate 358, of whom 176 were treated. 19 patients received nivolumab monotherapy, 45 received NIVO3 plus IPI1, and 112 received NIVO1 plus IPI3 (45 in the randomised group and 67 in the expansion group). Median follow-up times were 19·9 months (IQR 8·2-44·8) with nivolumab, 12·6 months (7·8-37·1) with NIVO3 plus IPI1, and 16·7 months (7·2-27·5) with pooled NIVO1 plus IPI3. Objective response rate...
Source: Ann Oncol - April 12, 2024 Category: Cancer & Oncology Authors: Ana Oaknin Kathleen Moore Tim Meyer Jos é López-Picazo González Lot A Devriese Asim Amin Christopher D Lao Valentina Boni William H Sharfman Jong Chul Park Makoto Tahara Suzanne L Topalian Manuel Magallanes Alejandro Molina Alavez Tariq Aziz Khan Cathe Source Type: research
Prolonged arthralgias in Whipple's disease - A common but often overlooked symptom of a rare disease
We report the case of a middle-aged man admitted for etiologic investigation of prolonged, migrating, and inflammatory arthralgias and subsequent development of gastrointestinal symptoms. Despite its reputation as a great mimicker of many different illnesses, the difficulty in diagnosis probably lies with its rarity rather than its masking.PMID:38606805 | DOI:10.1177/14782715241237283 (Source: Journal of the Royal College of Physicians of Edinburgh)
Source: Journal of the Royal College of Physicians of Edinburgh - April 12, 2024 Category: General Medicine Authors: Bernardo Tourais Canh ão Andr é Trigo Joana In ês Madeira Ad élia Simão Jo ão Madaleno Source Type: research
Diabetes and the gastrointestinal tract
Gastrointestinal (GI) complications of diabetes mellitus are common and substantially decrease health-related quality of life. Diabetes can affect every part of the GI tract, from the oesophagus to the rectum, and causes various symptoms, including reflux, heartburn, nausea, vomiting, abdominal pain, diarrhoea and constipation. Diabetes-induced GI complications are collectively referred to as diabetic gastroenteropathy. Over recent years, investigation of the underlying pathogenesis of diabetes-induced GI complications has provided objective evidence of abnormalities in the enteric nervous system, essential for normal moti...
Source: Medicine - April 11, 2024 Category: Internal Medicine Authors: Anne-Marie Wegeberg, Christina Brock Tags: New advances Source Type: research
Low-dose colchicine for atherosclerosis: long-term safety
Eur Heart J. 2024 Apr 10:ehae208. doi: 10.1093/eurheartj/ehae208. Online ahead of print.ABSTRACTLow-dose colchicine (0.5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice. In this State-of-the-Art Review, data were collated from contemporary systemic reviews of case reports, drug registries, and placebo-controlled trials that assessed specific issues of safety related to the continuous use of colchicine in a range of clinical settings to inform physicians, pharmacists, and patients of the absolute risks of continuous use of low-...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Stefan Mark Nidorf Eldad Ben-Chetrit Paul M Ridker Source Type: research
Low-dose colchicine for atherosclerosis: long-term safety
Eur Heart J. 2024 Apr 10:ehae208. doi: 10.1093/eurheartj/ehae208. Online ahead of print.ABSTRACTLow-dose colchicine (0.5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice. In this State-of-the-Art Review, data were collated from contemporary systemic reviews of case reports, drug registries, and placebo-controlled trials that assessed specific issues of safety related to the continuous use of colchicine in a range of clinical settings to inform physicians, pharmacists, and patients of the absolute risks of continuous use of low-...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Stefan Mark Nidorf Eldad Ben-Chetrit Paul M Ridker Source Type: research
Low ‑dose venetoclax combined with azacitidine in older and frail patients with newly diagnosed acute myeloid leukaemia
In conclusion, preliminary results indicated that low-dose venetoclax combined with azacitidine is effective and safe for the treatment of older and frail patients with newly diagnosed AML, providing a new treatment option for these patients.PMID:38586209 | PMC:PMC10996028 | DOI:10.3892/ol.2024.14362 (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Chunmeng Rong Fang Yang Yalu Chen Ming Wang Cheng Ai Yuqing Luo Panpan Gao Yiqin Weng Xiaguang Huang Meier Gu Weiping Huang Yongming Xia Source Type: research
Preoperative nutrition therapy in people undergoing gastrointestinal surgery
CONCLUSIONS: We were unable to determine if parenteral nutrition, enteral nutrition, immune-enhancing nutrition or standard oral nutrition supplements have any effect on the clinical outcomes due to very low-certainty evidence. There is some evidence that standard oral nutrition supplements may have no effect on complications. Sensitivity analysis showed standard oral nutrition supplements probably reduced infections in weight-losing or malnourished participants. Further high-quality multicentre research considering the ERAS programme is required and further research in low- and middle-income countries is needed.PMID:38588...
Source: Cochrane Database of Systematic Reviews - April 8, 2024 Category: General Medicine Authors: Anne Marie Sowerbutts Sorrel Burden Jana Sremanakova Chloe French Stephen R Knight Ewen M Harrison Source Type: research
Chronic underlying gastrointestinal amyloidosis was revealed by cardiac echography: a case report from Syria
CONCLUSION: This case reminds us to consider amyloidosis as a possible underlying cause for unexplained gastrointestinal symptoms such as diarrhoea, especially in bad economic situations where the diagnosis of rare diseases may be delayed.PMID:38576978 | PMC:PMC10990300 | DOI:10.1097/MS9.0000000000001901 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Ali Asaad Yahia Ranjous Zein Aldeen Hassan Nazir Alahmad Lama Ghanimeh Ayman Ali Source Type: research
