Clinical and atopic features of patients with primary eosinophilic colitis: an Italian multicentre study
AbstractEosinophilic colitis (EC) is the rarest among primary eosinophilic gastrointestinal disorders (EGID). EC is underdiagnosed due to its blurred and proteiform clinical manifestations. To explore the clinical and atopic characteristic of EC adult patients, the diagnostic delay, and relapse-associated factors, by comparison with patients with eosinophilic esophagitis (EoE) and irritable bowel syndrome (IBS). EC patients followed-up at four clinics were included, and clinical, histopathological, and laboratory data were retrieved. As control groups, age-matched patients with EoE and IBS were recruited. Allergy tests inc...
Source: Internal and Emergency Medicine - March 10, 2024 Category: Emergency Medicine Source Type: research
< em > Tamarind < /em > genus chemical composition and biological activities
This article provides an overview of the identified chemicals from T. indica together with their stated biological activities.PMID:38454320 | DOI:10.1080/14786419.2024.2323531 (Source: Natural Product Research)
Source: Natural Product Research - March 8, 2024 Category: Biochemistry Authors: Nahla S El-Gazzar Source Type: research
A phase I study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer
CONCLUSIONS: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase III trial (No. NCT05122494).PMID:38455366 | PMC:PMC10915640 | DOI:10.21147/j.issn.1000-9604.2024.01.05 (Source: Cancer Control)
Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Pin Zhang Lin Wang Yueying Zhen Zhihong Wang Hesheng Zhang Richard Jones Binghe Xu Source Type: research
< em > Tamarind < /em > genus chemical composition and biological activities
This article provides an overview of the identified chemicals from T. indica together with their stated biological activities.PMID:38454320 | DOI:10.1080/14786419.2024.2323531 (Source: Natural Product Research)
Source: Natural Product Research - March 8, 2024 Category: Biochemistry Authors: Nahla S El-Gazzar Source Type: research
< em > Tamarind < /em > genus chemical composition and biological activities
This article provides an overview of the identified chemicals from T. indica together with their stated biological activities.PMID:38454320 | DOI:10.1080/14786419.2024.2323531 (Source: Natural Product Research)
Source: Natural Product Research - March 8, 2024 Category: Biochemistry Authors: Nahla S El-Gazzar Source Type: research
Prevalence and correlates of paediatric guideline non-adherence for initial empirical care in six low and middle-income settings: a hospital-based cross-sectional study
Conclusions
Non-adherence to paediatric guidelines was common and associated with older age, disease severity, and comorbidities, and lower household economic status. These findings highlight opportunities to improve guidelines by adding clarity to specific recommendations. (Source: BMJ Open)
Source: BMJ Open - March 8, 2024 Category: General Medicine Authors: Shawon, R. A., Denno, D., Tickell, K. D., Atuhairwe, M., Bandsma, R., Mupere, E., Voskuijl, W., Mbale, E., Ahmed, T., Chisti, M. J., Saleem, A. F., Ngari, M., Diallo, A. H., Berkley, J., Walson, J., Means, A. R. Tags: Open access, Evidence based practice Source Type: research
Ferric citrate for the treatment of hyperphosphatemia and iron deficiency anaemia in patients with NDD-CKD: a systematic review and meta-analysis
Conclusion: This meta-analysis found that ferric citrate had a beneficial effect in the treatment of NDD-CKD, particularly in reducing blood phosphorus levels when compared to a control intervention. It also shown that ferric citrate has a favourable effect on iron intake and anaemia management. In terms of safety, ferric citrate may increase the likelihood of gastrointestinal side effects. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients
Recently in Gut, several reviews and reports have highlighted hypomorphic (dysfunctional) variants of the sucrase-isomaltase (SI) gene in relation to increased risk of irritable bowel syndrome (IBS), particularly the diarrhoea-predominant type (IBS-D).1–4 Similar to congenital (rare recessive) and acquired forms of SI deficiency, impaired SI enzymatic activity is expected to lead to colonic accumulation of undigested disaccharides, thus triggering IBS manifestations via gut microbiota fermentation, gas production and osmotic diarrhoea. Reduced efficacy of a diet low in FODMAPs (fermentable oligosaccharides, disacchar...
Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Zamfir-Taranu, A., Löscher, B.-S., Husein, D. M., Hoter, A., Garcia-Etxebarria, K., Etxeberria, U., Gayoso, L., Mayr, G., Nilholm, C., Gustafsson, R. J., Ozaydin, O., Zheng, T., Esteban-Blanco, C., Bozzarelli, I., Bonfiglio, F., Rizk, S., Franke, Tags: Open access, Gut PostScript Source Type: research
Coutilisation of oral rehydration solution and zinc for treating diarrhoea and its associated factors among under-five children in East Africa: a multilevel robust Poisson regression
Conclusion
Only half of the under-5 children with diarrhoea in East Africa were treated with a combination of ORS and zinc. To increase the use of the suggested combination therapy of ORS with zinc, it is important to empower women through education and prevent teen pregnancy. (Source: BMJ Open)
Source: BMJ Open - March 7, 2024 Category: General Medicine Authors: Legesse, B. T., Wondie, W. T., Gedefaw, G. D., Workineh, Y. T., Seifu, B. L. Tags: Open access, Public health Source Type: research
Sacituzumab Govitecan: A Review in Unresectable or Metastatic HR+/HER2 − Breast Cancer
AbstractSacituzumab govitecan (TRODELVY®) is a first-in-class trophoblast cell-surface antigen 2 (Trop-2) –directed antibody and topoisomerase I inhibitor conjugate that is approved globally as monotherapy for the treatment of adults with unresectable locally advanced or metastatic, hormone receptor-positive (HR+)/human epidermal growth factor receptor 2–negative (HER2−; defined as immunohistochem istry 0, 1+ or 2+ and in situ hybridization-negative) breast cancer who have received endocrine-based therapy and ≥ 2 additional systemic therapies in the advanced setting. In the phase III TROPiCS-02 trial, intravenous...
Source: Targeted Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | PMC:PMC10916892 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
