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Impact of Saussurea lappa against foodborne parasite Trichinella spiralis experimental infections induced variation in DNA damage, oxidative stress and PCNA expression in rat skeletal muscles
Toxicol Res (Camb). 2024 Mar 23;13(2):tfae047. doi: 10.1093/toxres/tfae047. eCollection 2024 Apr.ABSTRACTTrichinellosis is a parasite zoonosis that is spread through ingesting raw or undercooked meat that contains the Trichinella spiralis (T. spiralis) infective larvae. It has three clinical phases: intestinal, migratory, and muscular. Kuth root, also known as Costus (Saussurea lappa) roots, is used in many traditional medical systems all over the world to treat a variety of illnesses, such as dyspepsia, diarrhoea, vomiting, and inflammation. Current study assessed the therapeutic Potential of costus roots extract (CRE) tr...
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Areej Jameel M Alghabban Lamiaa Bakr Aya A Elbatawy Afaf El Atrash Ehab Tousson Source Type: research

Promoting Responsible Antibiotic Usage in Dental Implant Procedures
Antibiotic prophylaxis in the context of dental implant procedures has been a matter of controversy. The use of antibiotics as a preventive measure aims to minimize the risk of postoperative infections associated with implant placement. 1 While there is a consensus on the importance of preventing infections, the specific protocols for antibiotic prophylaxis have been a matter of debate. Antibiotics may lead to a variety of side effects, from diarrhoea to life-threatening allergic reactions. Moreover, the extensive use of antibiotics is associated with the rise of antibiotic-resistant bacteria. (Source: Journal of Oral and ...
Source: Journal of Oral and Maxillofacial Surgery - March 26, 2024 Category: ENT & OMF Authors: Naushad R. Edibam, Ranimol Prasanna, Bach Le Tags: Perspectives Source Type: research

Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro 
CONCLUSION: This study proves that both matrine and icariin have inhibitory effects on BVDV replication by activating IFN production and the IFN signalling pathway. The finding is promising and should open up the possibility of larger-scale in vitro research followed by in vivo experiments evaluating matrine and icariin as therapeutic agents in BVD cases.PMID:38525227 | PMC:PMC10960331 | DOI:10.2478/jvetres-2024-0013 (Source: Cell Research)
Source: Cell Research - March 25, 2024 Category: Cytology Authors: Dongjie Cai Zifan Shen Bin Tian Jie Chen Yilin Zhang Liuhong Shen Ya Wang Xiaoping Ma Zhicai Zuo Source Type: research

Selective Internal Radiation Therapy Using Y-90 Resin Microspheres for Metastatic Colorectal Cancer: An Updated Systematic Review and Network Meta-Analysis
ConclusionCurrent evidence supports SIRT treatment in patients with chemotherapy-refractory or chemotherapy-intolerant mCRC compared to newer oral agents, with comparable OS and low incidence of AEs. (Source: Advances in Therapy)
Source: Advances in Therapy - March 24, 2024 Category: Drugs & Pharmacology Source Type: research

Lactobacillus casei Shirota probiotic drinks reduce antibiotic associated diarrhoea in patients with spinal cord injuries who regularly consume proton pump inhibitors: a subgroup analysis of the ECLISP multicentre RCT
Spinal Cord, Published online: 22 March 2024; doi:10.1038/s41393-024-00983-wLactobacillus casei Shirota probiotic drinks reduce antibiotic associated diarrhoea in patients with spinal cord injuries who regularly consume proton pump inhibitors: a subgroup analysis of the ECLISP multicentre RCT (Source: Spinal Cord)
Source: Spinal Cord - March 22, 2024 Category: Research Authors: Samford Wong Shashivadan P. Hirani Alastair Forbes Naveen Kumar Ramaswamy Hariharan Jean O ’Driscoll Ravi Sekhar Ali Jamous Source Type: research

Langerhans cell histiocytosis in children with refractory diarrhoea and hypoalbuminaemia as the initial presentation: two case reports and a literature review
We describe the cases of two patients who initially presented with chronic... (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 22, 2024 Category: Pediatrics Authors: Yi Cao, Qing-Qing Wu, Wei-Hui Yan, Li-Na Lu, Yi-Jing Tao, Hai-Xia Feng, Yi-Jing Chu, Wei Cai and Ying Wang Tags: Case Report Source Type: research

Return to flying duties of German military pilots after recovery from COVID-19
Conclusion Due to their demanding working environment, pilots, and other high-hazard employees, should undergo medical evaluation prior to return to their duties to exclude ongoing symptoms and the development of post-acute COVID-19 or post-COVID-19 syndrome. The scope of examinations may depend on the severity of the disease, comorbidities, the vaccination status, the predominant SARS-CoV-2 variant and the type of aircraft flown. (Source: Journal of the Royal Army Medical Corps)
Source: Journal of the Royal Army Medical Corps - March 20, 2024 Category: General Medicine Authors: Adam, T., Sammito, S., Nicol, E., Guettler, N. J. Tags: COVID-19 Original research Source Type: research

National study on the risks of COVID-19 infection for paediatric kidney transplant recipients: a retrospective, cross-sectional study
Conclusion We report 10.4% of the UK paediatric renal transplantation population had documented COVID-19 infections with positive SARS-CoV-2 PCR RNA with 28% of those affected requiring hospitalisation. The increased incidence of AKI, particularly after the first wave of the COVID-19 pandemic, was possibly due to increased testing. There was low morbidity and mortality compared with the adult population. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - March 19, 2024 Category: Pediatrics Authors: Withers, C., Patel, R., Reynolds, B. C., Christian, M., Muorah, M., Tse, Y., Edwards, L., Yadav, P., Haq, S., Hegde, S., Callaghan, C. J., Bamford, A., Marks, S. D. Tags: COVID-19 Original research Source Type: research

Fatal coinfection of blastocystosis and intestinal trichomoniasis in a rhesus macaque (Macaca mulatta)
AbstractA 3-year-old male rhesus macaque was presented at Referral Veterinary Polyclinic-Teaching Veterinary Clinical Complex, with a chief complaint of chronic diarrhoea and swelling of dependent body parts. The patient's history indicates that the monkey had been experiencing diarrhoea for the past month, with 2 –3 episodes of vomiting in the last 2 days. Additionally, oedema has developed within the last 2 weeks. The clinical examination findings revealed dullness and depression, the mucus membrane appeared pale, with a temperature-102.1 °F, a respiration rate-28/min, and a heart rate-92/min. The cap illary refill...
Source: Journal of Parasitic Diseases - March 19, 2024 Category: Parasitology Source Type: research

Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis
Eur J Microbiol Immunol (Bp). 2024 Mar 18. doi: 10.1556/1886.2024.00013. Online ahead of print.ABSTRACTSchistosomiasis is a neglected tropical disease that is prevalent in low- and middle-income countries. There are five human pathogenic species, of which Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum are the most prevalent worldwide and cause the greatest burden of disease in terms of mortality and morbidity. In addition, hybrid schistosomes have been identified through molecular analysis. Human infection occurs when cercariae, the larval form of the parasite, penetrate the skin of people while bat...
Source: Cancer Control - March 18, 2024 Category: Cancer & Oncology Authors: Elena Ponzo Angelina Midiri Andrea Manno Martina Pastorello Carmelo Biondo Giuseppe Mancuso Source Type: research

Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery
AAPS PharmSciTech. 2024 Mar 14;25(3):61. doi: 10.1208/s12249-024-02764-3.ABSTRACTMesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential. Besides conventional pharmacotherapy, bifidogenic probiotics with anti-inflammatory activity has been reported to elicit a significant impact on the remission of ulcerative colitis. Bifidogenic probiotics being acid-labile necessitate developing a gas...
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Jagtar Singh Mohit Sharma Harmeet Singh Pinky Arora Puneet Utreja Shubham Kumar Source Type: research

Norovirus GII.17 Caused Five Outbreaks Linked to Frozen Domestic Bilberries in Finland, 2019
AbstractIn March 2019, the Finnish Institute for Health and Welfare and Finnish Food Authority started an outbreak investigation after a notification of food business operators ’ recall of frozen bilberries due to a norovirus finding. A retrospective search was conducted in the food and waterborne outbreak notification system to identify the notifications linked to norovirus and consumption of bilberries in January–March 2019. Five outbreaks were found in which norovir us GII or GII.17 had been detected in patient samples. A pooled retrospective cohort study was performed for those four in which a questionnaire study h...
Source: Food and Environmental Virology - March 11, 2024 Category: Virology Source Type: research