Case Report: The leopard sign as a potential characteristic of chronic granulomatous disease-associated colitis, unrelated to colitis severity
ConclusionThe leopard sign in the colon may be a characteristic endoscopic finding of CGD, even in patients who do not develop severe gastrointestinal symptoms; however, it does not reflect the severity of CGD-associated colitis. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 13, 2023 Category: Allergy & Immunology Source Type: research
< em > Rubus moluccanus < /em > L.: a valuable medicinal plant of traditional system of medicine
Nat Prod Res. 2023 Dec 11:1-11. doi: 10.1080/14786419.2023.2291706. Online ahead of print.ABSTRACTRubus moluccanus L., commonly known as Molucca bramble or broad-leaf bramble is a member of family Rosaceae which occurs mainly in tropical Asia and Australia. It has applications in indigenous medicines and is used in the treatment of number of ailments like headache, diarrhoea, dysentery, abdominal pain, nocturnal micturition of children and enhancement of female fertility. This plant is a rich and valuable source of bioactive flavonoids, terpenes and other chemical compounds. The presence of these active chemical compounds ...
Source: Natural Product Research - December 11, 2023 Category: Biochemistry Authors: Taruba Ansari Mohd Asif Mohd Saleem Noor Zaheer Ahmed Rampratap Meena Source Type: research
Final analysis of phase II results with cemiplimab in metastatic basal cell carcinoma after hedgehog pathway inhibitors
CONCLUSIONS: Cemiplimab demonstrated clinically meaningful antitumour activity, including durable responses, and an acceptable safety profile in patients with mBCC who had disease progression on or intolerance to HHI therapy.PMID:38072158 | DOI:10.1016/j.annonc.2023.10.123 (Source: Ann Oncol)
Source: Ann Oncol - December 10, 2023 Category: Cancer & Oncology Authors: K D Lewis K Peris A Sekulic A J Stratigos L Dunn Z Eroglu A L S Chang M R Migden S-Y Yoo K Mohan E Coates E Okoye T Bowler J-F Baurain O Bechter A Hauschild M O Butler L Hernandez-Aya L Licitra R I Neves E S Ruiz F Seebach I Lowy P Goncalves M G Fury Source Type: research
Cholecystectomy is associated with a higher risk of irritable bowel syndrome in the UK Biobank: a prospective cohort study
Conclusion: Cholecystectomy was associated with a higher risk of IBS, especially IBS with diarrhoea. Additional prospective randomized controlled and experimental studies are warranted to further validate the association and to explore the relevant biological mechanisms. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 8, 2023 Category: Drugs & Pharmacology Source Type: research
Non-pharmacological interventions for chemotherapy-induced diarrhoea and constipation management: A scoping review
Chemotherapy-induced diarrhoea (CID) and constipation (CIC) are among the most common and severe gastrointestinal symptoms related to chemotherapy. This review aimed to identify and describe the evidence for non-pharmacological interventions for the management of CID and CIC. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - December 8, 2023 Category: Cancer & Oncology Authors: Thi Hanh Phung, Erin Pitt, Kimberly Alexander, Natalie Bradford Source Type: research
Diagnostic dilemma: a patient with diarrhoea
Clinical presentation A Sudanese man in his early 40s was admitted to our tertiary healthcare centre with a 3-month history of abdominal pain, fevers and intermittent diarrhoea on the background of a known bladder lesion awaiting a transurethral resection. The patient denied any other constitutional symptoms and did not have any other significant medical history. On examination, the patient was febrile, but otherwise haemodynamically stable. There was bilateral cervical and left supraclavicular lymphadenopathy with generalised abdominal tenderness without any palpable masses. Admission laboratory investigations demonstrate...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Sane, N., Bloom, A. Tags: GUT Snapshot, Gut Editor ' s quiz: GI snapshot Source Type: research
Type 2 autoimmune pancreatitis associated with ulcerative colitis
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disease mainly affecting the rectum and colon and causing diarrhoea and mucopurulent stools. UC can present with extraintestinal manifestations in various organs and systems and can be associated with various comorbidities. Autoimmune pancreatitis (AIP) is a specific type of pancreatitis associated with autoimmune abnormalities and is divided into two clinical types: type 1 (lymphoplasmacytic sclerosing pancreatitis) and type 2 (idiopathic ductocentric pancreatitis). The current study shows an association between type 2 AIP and UC, which may be related to genetic...
Source: Frontiers in Immunology - December 6, 2023 Category: Allergy & Immunology Source Type: research
Promoting wound recovery through stable intestinal flora: Reducing post-operative complications in colorectal cancer surgery patients
This study examined the relationship between intestinal flora stability and post-operative recovery in patients undergoing CRC surgery. Between May 2020 and 2023, 80 CRC patients from our hospital's Colorectal Surgery Department were enrolled. A random number table was used to divide them into two categories. Both groups were subjected to distinct gastrointestinal preparation protocols. Indicators of clinical therapeutic effect, intestinal flora balance following surgery, post-operative complications and quality of life were evaluated. The observation group, which adhered to a distinct gastrointestinal regimen, demonstrate...
Source: Cancer Control - December 5, 2023 Category: Cancer & Oncology Authors: Qiao Chen Zhi Wang Bai Xiang Wu Source Type: research
The host protein CALCOCO2 interacts with bovine viral diarrhoea virus Npro, inhibiting type I interferon production and thereby promoting viral replication
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - December 4, 2023 Category: Virology Authors: Song WangRan WeiXiaomei MaJin GuoMuhammad AizazFangxu LiJun WangHongmei WangHongbin Hea Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong, Chinab Ruminant Diseases Research Center, College of Life Sciences, Sha Source Type: research
HIV enteropathy (HIVE) and Slim disease (SD): historical and current perspectives
The emergence of the human immunodeficiency virus (HIV) epidemic in Africa was first reported among patients originating from Central Africa presenting with severe wasting symptoms resembling marasmus in 1983. The illness was associated commonly with chronic, and often life-threatening diarrhoea [1]. There was no evidence of an underlying immunosuppressive disease, no history of blood-product transfusion, homosexuality, or intravenous-drug abuse and the disease appeared to affect females as frequently as males. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - December 3, 2023 Category: Infectious Diseases Authors: MS Kapembwa, PA Batman, SC Fleming, GE Griffin Tags: Review Source Type: research
HIV enteropathy and ‘Slim disease’: Historical and current perspectives
The emergence of the HIV epidemic in Africa was first reported among patients originating from Central Africa presenting with severe wasting symptoms resembling marasmus in 1983. The illness was associated commonly with chronic, and often life-threatening diarrhoea [1]. There was no evidence of an underlying immunosuppressive disease, no history of blood-product transfusion, homosexuality, or intravenous-drug abuse and the disease appeared to affect females as frequently as males. A similar illness was described in a cohort of Haitian patients in 1984. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - December 3, 2023 Category: Infectious Diseases Authors: Moses Silungwe Kapembwa, Philip Anthony Batman, Simon Charles Fleming, George Edward Griffin Tags: Review Source Type: research
Clofazimine is a safe and effective alternative for rifampicin in Mycobacterium avium complex pulmonary disease treatment - outcomes of a randomized trial
Chest. 2023 Nov 29:S0012-3692(23)05830-0. doi: 10.1016/j.chest.2023.11.038. Online ahead of print.ABSTRACTBACKGROUND: Retrospective studies have suggested clofazimine as an alternative for rifampicin in MAC-PD treatment.RESEARCH QUESTION: Is a treatment regimen consisting of clofazimine-ethambutol-macrolide non inferior to the standard treatment regimen (rifampicin-ethambutol-macrolide) in the treatment of M.avium complex pulmonary disease?STUDY DESIGN AND METHODS: In this single centre non-blinded clinical trial, we randomly assigned adult patients with MAC-PD in a 1:1 ratio to receive rifampicin or clofazimine as adjunct...
Source: Chest - December 1, 2023 Category: Respiratory Medicine Authors: Sanne M H Zweijpfenning Rob Aarnoutse Martin J Boeree Cecile Magis-Escurra Ralf Stemkens Bram Geurts Jakko van Ingen Wouter Hoefsloot Source Type: research
Clofazimine is a safe and effective alternative for rifampicin in Mycobacterium avium complex pulmonary disease treatment - outcomes of a randomized trial
Chest. 2023 Nov 29:S0012-3692(23)05830-0. doi: 10.1016/j.chest.2023.11.038. Online ahead of print.ABSTRACTBACKGROUND: Retrospective studies have suggested clofazimine as an alternative for rifampicin in MAC-PD treatment.RESEARCH QUESTION: Is a treatment regimen consisting of clofazimine-ethambutol-macrolide non inferior to the standard treatment regimen (rifampicin-ethambutol-macrolide) in the treatment of M.avium complex pulmonary disease?STUDY DESIGN AND METHODS: In this single centre non-blinded clinical trial, we randomly assigned adult patients with MAC-PD in a 1:1 ratio to receive rifampicin or clofazimine as adjunct...
Source: Chest - December 1, 2023 Category: Respiratory Medicine Authors: Sanne M H Zweijpfenning Rob Aarnoutse Martin J Boeree Cecile Magis-Escurra Ralf Stemkens Bram Geurts Jakko van Ingen Wouter Hoefsloot Source Type: research
