Association of a device ‐based remote management heart failure pathway with outcomes: TriageHF Plus real‐world evaluation
ConclusionsThese data represent the largest real-world evaluation of a DHFP based on multi-parametric risk stratification. The TriageHF Plus clinical pathway was associated with an improvement in HF symptoms and reduced all-cause hospitalizations. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 7, 2024 Category: Cardiology Authors: Fozia Zahir Ahmed,
Camilla Sammut ‐Powell,
Glen P. Martin,
Paul Callan,
Colin Cunnington,
Matthew Kahn,
Mita Kale,
Toni Weldon,
Rachel Harwood,
Catherine Fullwood,
Bart Gerritse,
David Lanctin,
Nelson Soken,
Niall G. Campbell,
Joanne K. Ta Tags: Original Article Source Type: research
Sociodemographic factors associated with vaccine hesitancy in the South Asian community in Canada
CONCLUSION: Among South Asians living in ON and BC, time since immigration, prior COVID-19 infection, marital status, living in a multigenerational household, age, education, and employment status were associated with vaccine hesitancy. This information can be used to address vaccine hesitancy in the South Asian population in future COVID-19 waves or pandemics.PMID:38713364 | DOI:10.17269/s41997-024-00885-7 (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - May 7, 2024 Category: International Medicine & Public Health Authors: Baanu Manoharan Rosain Stennett Russell J de Souza Shrikant I Bangdiwala Dipika Desai Sujane Kandasamy Farah Khan Zainab Khan Scott A Lear Lawrence Loh Rochelle Nocos Karleen M Schulze Gita Wahi Sonia S Anand Source Type: research
Socio-ecological factors linked with changes in adults' dietary intake in Los Angeles County during the peak of the COVID-19 pandemic
CONCLUSIONS: Given poor diets are a leading cause of death in the U.S., addressing ecological risk factors that put some segments of the community at risk for unhealthy dietary changes during a crisis should be a priority for health interventions and policy.PMID:38711182 | DOI:10.1017/S1368980024001034 (Source: Public Health Nutrition)
Source: Public Health Nutrition - May 7, 2024 Category: International Medicine & Public Health Authors: Sydney Miller Trevor Pickering Wandi Bruine de Bruin Tom Valente John Wilson Kayla de la Haye Source Type: research
Neonatal past catches up when COVID-19 comes to town
Pediatr Res. 2024 May 7. doi: 10.1038/s41390-024-03237-w. Online ahead of print.NO ABSTRACTPMID:38714862 | DOI:10.1038/s41390-024-03237-w (Source: Pediatric Research)
Source: Pediatric Research - May 7, 2024 Category: Pediatrics Authors: Georgie Dowse David G Tingay Julia Charlton Source Type: research
Association between COVID-19 Severity and Expression of Viral Nucleic Acid Sensor Genes in Peripheral Blood Mononuclear Cells and Nasopharyngeal Epithelial Cells
This study examined expression of key viral nucleic acid sensor genes MDA5, ZBP1, and AIM2 in nasopharyngeal epithelial cells and peripheral blood mononuclear cells (PBMCs) obtained from 153 COVID-19 patients across a spectrum of disease severity (mild, severe, and critical) and 42 healthy controls. Quantitative reverse transcription polymerase chain reaction was used to quantify and compare sensor transcript levels. The COVID-19 cohort had a mean age of 53.6 years. All three sensor genes including MDA5 (3.2-fold), ZBP1 (5.1-fold), and AIM2 (4.7-fold) exhibited significantly higher messenger RNA expression in both nasophar...
Source: Am J Trop Med Hyg - May 7, 2024 Category: Infectious Diseases Authors: Zohreh-Al-Sadat Ghoreshi Emad Behboudi Hedyeh Askarpour Fatemeh Raesi Nejad Nasir Arefinia Source Type: research
Clinical characteristics, imaging, and lung function among patients with persistent dyspnea of COVID-19: a retrospective observational cohort study
In conclusion, longer-term studies will help further our understanding of the risk factors, disease course, and prognosis of long COVID patients.PMID:38713158 | DOI:10.4081/monaldi.2024.2733 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - May 7, 2024 Category: Respiratory Medicine Authors: Ravi Manglani Moshe Fenster Theresa Henson Ananth Jain Neil Schluger Source Type: research
Analysis of the fight against the COVID-19 pandemic in long-term care facilities in the pre-vaccination period
CONCLUSION: The correct classification of the degree of frailty of institutionalized older people seems to have been relevant for predicting mortality from COVID-19. The extensive assistance by private health plans, contrary to what is supposed, did not result in better health protection. Early geriatric follow-up was beneficial and may be an attractive strategy in the face of health emergencies that affect long-term care facilities to reduce hospital admissions.PMID:38714293 | DOI:10.1016/j.bjid.2024.103748 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 7, 2024 Category: Infectious Diseases Authors: J áder Freitas Maciel Garcia de Carvalho Rodrigo Ribeiro Dos Santos Alcimar Marcelo do Couto Juliana Santos Neves Fl ávia Lanna de Moraes Cristiana Ceotto Deslandes Viviane Rodrigues Jardim Thiara Joanna Pe çanha da Cruz Tavares Raquel Souza Azevedo Ed Source Type: research
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Nat Biomed Eng. 2024 May 7. doi: 10.1038/s41551-024-01208-4. Online ahead of print.ABSTRACTMessenger RNA vaccines lack specificity for dendritic cells (DCs)-the most effective cells at antigen presentation. Here we report the design and performance of a DC-targeting virus-like particle pseudotyped with an engineered Sindbis-virus glycoprotein that recognizes a surface protein on DCs, and packaging mRNA encoding for the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or for the glycoproteins B and D of herpes simplex virus 1. Injection of the DC-targeting SARS-CoV-2 mRNA vaccine in the footpad ...
Source: Herpes - May 7, 2024 Category: Infectious Diseases Authors: Di Yin Yiye Zhong Sikai Ling Sicong Lu Xiaoyuan Wang Zhuofan Jiang Jie Wang Yao Dai Xiaolong Tian Qijing Huang Xingbo Wang Junsong Chen Ziying Li Yang Li Zhijue Xu Hewei Jiang Yuqing Wu Yi Shi Quanjun Wang Jianjiang Xu Wei Hong Heng Xue Hang Yang Yan Zhan Source Type: research
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses
bioRxiv [Preprint]. 2024 Apr 26:2024.04.26.591186. doi: 10.1101/2024.04.26.591186.ABSTRACTPARP14 is a 203 kDa multi-domain protein that is primarily known as an ADP-ribosyltransferase, and is involved in a variety of cellular functions including DNA damage, microglial activation, inflammation, and cancer progression. In addition, PARP14 is upregulated by interferon (IFN), indicating a role in the antiviral response. Furthermore, PARP14 has evolved under positive selection, again indicating that it is involved in host-pathogen conflict. We found that PARP14 is required for increased IFN-I production in response to coronavir...
Source: Herpes - May 7, 2024 Category: Infectious Diseases Authors: Srivatsan Parthasarathy Pradtahna Saenjamsai Hongping Hao Anna Ferkul Jessica J Pfannenstiel Ellen L Suder Daniel S Bejan Yating Chen Nancy Schwarting Masanori Aikawa Elke Muhlberger Robin C Orozco Christopher S Sullivan Michael S Cohen David J Davido Ada Source Type: research
Exosome may be the next generation of promising cell-free vaccines
In this study, we reviewed the origin, classification, functions, modifications, separation and purification, and characterization methods of exosomes. Meanwhile, we focused on the role and mechanism of exosomes for cancer and COVID-19 vaccines.PMID:38714324 | DOI:10.1080/21645515.2024.2345940 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Zelan Dai Ruiru Cai Hong Zeng Hailian Zhu Youwei Dou Shibo Sun Source Type: research
Association between Usage of Prophylactic AYUSH Medicines and Disease Severity in COVID-19 Patients: A Retrospective Cohort Study
CONCLUSION: AYUSH prophylactics were associated with statistically significant levels of protection against COVID-19 disease severity. Amongst these, previous intake of homeopathy or Siddha medicines was associated with some protection against moderate/severe illness and with a somewhat quicker clinical recovery. Prospective studies with experimental research design are needed to validate the findings of this study.STUDY REGISTRATION: Clinical Trials Registry-India (CTRI/2020/08/027000).PMID:38714214 | DOI:10.1055/s-0044-1779693 (Source: Homeopathy)
Source: Homeopathy - May 7, 2024 Category: Complementary Medicine Authors: Anupriya Chaudhary Debadatta Nayak Swati Pandey Vipul Shastri Madhuri Kamble Vidya Pendse Vismay Prajapati Brijesh Vaidya Heenal Rohit Swaroopa Beedmani Nutan Presswala Tejaswini Patole Ramesh Bawaskar Vaishali Shinde Mohua Datta Gunjan Rai Umakanta Prust Source Type: research
Intranasal immunization with the bivalent SARS-CoV-2 vaccine effectively protects mice from nasal infection and completely inhibits disease development
Vaccine. 2024 May 6:S0264-410X(24)00519-X. doi: 10.1016/j.vaccine.2024.04.079. Online ahead of print.ABSTRACTWith the continuous emergence of coronavirus disease 2019 (COVID-19) waves, the scientific community has developed a vaccine that offers broad-spectrum protection at virus-targeted organs for inhibiting the transmission and protection of disease development. In the present study, a bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine containing receptor-binding domain (RBD) protein of spike from Wuhan-1 and omicron BA.1 loaded in nanoparticles, bivalent RBD NPs, was developed. The immunogeni...
Source: Vaccine - May 7, 2024 Category: Allergy & Immunology Authors: Tuksin Jearanaiwitayakul Panya Sunintaboon Anuwat Kittiayuwat Jitra Limthongkul Jidapar Wathanaphol Yada Janhirun Hatairat Lerdsamran Witthawat Wiriyarat Sukathida Ubol Source Type: research
mRNA COVID-19 vaccine safety among older adults from the Canadian National Vaccine Safety Network
This study examined short-to-medium term safety of COVID-19 vaccines among adults aged ≥65 years using the Canadian National Vaccine Safety Network active safety surveillance data. Both vaccinated and unvaccinated older adult participants recruited from seven provinces and territories were included in the analysis. Safety was assessed at 7 days after COVID-19 vaccination (dose 1, 2 and 3), and 7 months after dose 1. Multivariable logistic regression was used to examine the association between BNT162b2/mRNA-1273 COVID-19 vaccines and two short-term health events: 1) health event preventing daily activities and/or required...
Source: Vaccine - May 7, 2024 Category: Allergy & Immunology Authors: Phyumar Soe Hubert Wong Monika Naus Matthew P Muller Otto G Vanderkooi James D Kellner Karina A Top Manish Sadarangani Jennifer E Isenor Kimberly Marty Gaston De Serres Louis Valiquette Allison McGeer Julie A Bettinger Canadian Immunization Research Netwo Source Type: research
Low neutralization of SARS-CoV-2 Omicron BA.5.2.48 and XBB.1 sub-variants in response to breakthrough infection by booster
Vaccine. 2024 May 6:S0264-410X(24)00532-2. doi: 10.1016/j.vaccine.2024.04.093. Online ahead of print.ABSTRACTTo assess the levels of and neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its mutants in serum samples from patients with breakthrough infection. Sixty-four patients with breakthrough infections were recruited for this cross-sectional study. All samples were used to neutralizing antibodies (nAbs) against SARS-CoV-2 and its mutants using a focused reduction neutralization assay. A total of 512 serum samples were obtained from unvaccinated patients who received one do...
Source: Vaccine - May 7, 2024 Category: Allergy & Immunology Authors: Jianhua Li Liming Gong Jiaxuan Li Zhenyu Gong Xiaoxiao Wang Hao Yan Yanjun Zhang Haiyan Mao Keda Chen Source Type: research
Trust in governments, public health institutions, and other information sources as determinants of COVID-19 vaccine uptake behavior in Japan
CONCLUSIONS: Our findings support the broader hypothesis that trust in governments and public health institutions remains a powerful determinant for COVID-19 vaccine uptake in Japan. We also found that vaccination decision-making is a multifactorial process that includes the synthesis of trust in public institutions and media, and its interaction with psychosocial determinants such as prosociality and health literacy. We hope to apply this study's findings towards future vaccine programs for contagious diseases.PMID:38714450 | DOI:10.1016/j.vaccine.2024.04.081 (Source: Vaccine)
Source: Vaccine - May 7, 2024 Category: Allergy & Immunology Authors: Alton Cao Mami Ueta Manae Uchibori Michio Murakami Hiroyuki Kunishima Rauniyar Santosh Kumar Prapichaya Prommas Hana Tomoi Stuart Gilmour Haruka Sakamoto Masahiro Hashizume Wataru Naito Tetsuo Yasutaka Keiko Maruyama-Sakurai Hiroaki Miyata Shuhei Nomura Source Type: research
