Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
This study could stimulate further studies, optimization and potential applications of IgY antibodies as therapeutics and prophylactics for human and animals.PMID:38711133 | DOI:10.1186/s40659-024-00508-y (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Binan Zhao Haoran Peng Yanjing Zhang Jie Zhang Desheng Kong Sai Cao Yan Li Dan Yang Chuanwen Sun Xinyi Pu Ping Zhao Yan Xu Kai Zhao Liangzhi Xie Source Type: research
Persistent increased severity of cannabis use disorder symptoms in adolescents compared to adults: a one-year longitudinal study
Eur Arch Psychiatry Clin Neurosci. 2024 May 6. doi: 10.1007/s00406-024-01806-y. Online ahead of print.ABSTRACTAdolescence is a developmental period characterised by increased vulnerability to cannabis use disorder (CUD). However, previous investigations of this vulnerability have relied on cross-sectional comparisons and lack a detailed assessment of cannabis quantity, a potentially important confounding factor. Here, we aimed to investigate the one-year course of CUD in adolescents compared to adults who currently use cannabis, adjusting for a comprehensive measure of cannabis quantity. Data are from a one-year observatio...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 6, 2024 Category: Psychiatry Authors: Rachel Lees Will Lawn Kat Petrilli Amelia Brown Katie Trinci Anya Borissova Shelan Ofori Claire Mokrysz H Valerie Curran Lindsey A Hines Tom P Freeman Source Type: research
Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure
We examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells. We further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2. The suppressive effect o...
Source: Oncotarget - May 6, 2024 Category: Cancer & Oncology Authors: Shengliang Zhang Wafik S El-Deiry Source Type: research
SARS-CoV-2-specific T cell responses: a comparative analysis between QuantiFERON SARS-CoV-2, T-SPOT.COVID, and an in-house Omicron ELISpot
CONCLUSION: The evaluation of SARS-CoV-2 T cell immunity using commercially accessible assays may yield disparate outcomes as results from different assays are not directly comparable. A specific Omicron ELISpot should be considered to assess Omicron-specific T cell immunity.PMID:38710307 | DOI:10.1016/j.jviromet.2024.114949 (Source: Journal of Virological Methods)
Source: Journal of Virological Methods - May 6, 2024 Category: Virology Authors: Willem A Mak Wendy Visser Johannes G M Koeleman David S Y Ong Source Type: research
A stochastic scale conjugate neural network procedure for the SIRC epidemic delay differential system
In this study, a stochastic computing structure is provided for the numerical solutions of the SIRC epidemic delay differential model, i.e. SIRC-EDDM using the dynamics of the COVID-19. The design of the scale conjugate gradient (CG) neural networks (SCGNNs) is presented for the numerical treatment of SIRC-EDDM. The mathematical model is divided into susceptible S(ρ), recovered R(ρ), infected I(ρ), and cross-immune C(ρ), while the numerical performances have been provided into three different cases. The exactitude of the SCGNNs is perceived through the comparison of the accomplished and reference outcomes (Runge-Kutta ...
Source: Computer Methods in Biomechanics and Biomedical Engineering - May 6, 2024 Category: Biomedical Engineering Authors: Zulqurnain Sabir Atef F Hashem Zill E Shams M A Abdelkawy Source Type: research
An opportunity for management of fatigue, physical condition, and quality of life through asynchronous telerehabilitation in post-acute COVID-19 patients: a randomized controlled pilot study
CONCLUSION: A multimodal rehabilitation program by means of asynchronous telerehabilitation appears as a more effective option than traditional formats in improving post-acute COVID-19 sequelae.PMID:38710426 | DOI:10.1016/j.apmr.2024.04.014 (Source: Health Physics)
Source: Health Physics - May 6, 2024 Category: Physics Authors: Beatriz Carpallo-Porcar Sandra Calvo Jorge Alamillo-Salas Pablo Herrero Manuel G ómez-Barrera Carolina Jim énez-Sánchez Source Type: research
Lessons learned from the COVID-19 pandemic: The importance of physician leadership in responding to rural community ecosystem disruptions
CONCLUSION: Healthcare policy and practice transformation should prioritise developing opportunities to strengthen physician leadership, particularly in rural areas that will be adversely affected by ecosystem disruption.INTRODUCTION: La pandémie de COVID-19 a représenté un défi sans précédent pour les médecins de famille en milieu rural. Les leçons tirées au cours des deux années écoulées peuvent aider à orienter les réponses aux futures perturbations de l'écosystème. Cette étude qualitative vise à explorer les expériences de leadership des médecins de famille ruraux canadiens pendant la pandémie de C...
Source: Canadian Journal of Rural Medicine - May 6, 2024 Category: Rural Health Authors: Alexandra Bland Anna de Waal Stefan Grzybowski Source Type: research
Retraction Note: The potential preventive role of a dietary supplement containing hydroxytyrosol in COVID-19: a multi-center study
This article has been retracted. The Publisher apologizes for any inconvenience this may cause.PMID:38708488 | DOI:10.26355/eurrev_202404_36067 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 6, 2024 Category: Drugs & Pharmacology Authors: K Dhuli C Micheletti M C Medori G Madeo G Bonetti K Donato F Gaffuri G M Tartaglia S Michelini A Fiorentino D Cesarz S T Connelly N Capodicasa M Bertelli Source Type: research
Behind the scenes: facilitators and barriers to developing state scarce resource allocation plans for the COVID-19 pandemic
Chest. 2024 May 4:S0012-3692(24)00541-5. doi: 10.1016/j.chest.2024.04.006. Online ahead of print.ABSTRACTBACKGROUND: In response to COVID-19, many states revised, developed, or attempted to develop plans to allocate scarce critical care resources in the event crisis standards of care were triggered. No prior analysis has assessed this plan development process, including whether plans were successfully adopted.RESEARCH QUESTION: How did states develop or revise scarce resource allocation plans during the COVID-19 pandemic and what were the barriers and facilitators to their development and adoption at the state level?STUDY ...
Source: Chest - May 6, 2024 Category: Respiratory Medicine Authors: Kirsten A Riggan Nicholas V Nguyen Jackson S Ennis Debra A DeBruin Richard R Sharp Jon C Tilburt Susan M Wolf Erin S DeMartino Source Type: research
Poland's first vascular access team 3-year analysis: Insights and learnings
CONCLUSIONS: The introduction of MCs as a possible option for peripheral venous access reduces the use of CVCs. Developing MCs programmes should be based on investing in staff competencies, which increases success rates. The nurses and physicians should be trained in infusion care to achieve better results in the use of MCs and LPCs. Increasing the competence of nurses in Poland is necessary for the implementation of full-service and top-level functioning of VAT.PMID:38708844 | DOI:10.1177/11297298241251502 (Source: The Journal of Vascular Access)
Source: The Journal of Vascular Access - May 6, 2024 Category: Surgery Authors: Maciej Latos Dariusz Kosson Mateusz Zawadka Source Type: research
The Best Predictor of Future Behavior May Be the Past: Exploring Behavior Change in Men Who Have Sex with Men Using Pre-exposure Prophylaxis in the Netherlands
Arch Sex Behav. 2024 May 6. doi: 10.1007/s10508-024-02863-z. Online ahead of print.ABSTRACTPre-exposure prophylaxis (PrEP) use prevents HIV transmission, and may lead to changes in sexual behavior. We aimed to explore sexual behavior over time, and identify predictors of behavior change in men who have sex with men (MSM) using PrEP at sexual health centers (SHC) in the Netherlands. We used longitudinal data from the national STI surveillance database (January 2018-June 2021) of HIV-negative MSM who first initiated PrEP in the national PrEP pilot. We modelled behavior change after PrEP initiation, and identified predictors ...
Source: Archives of Sexual Behavior - May 6, 2024 Category: Psychiatry & Psychology Authors: Daphne van Wees Liza Coyer Mark van den Elshout Eline Op de Coul Fleur van Aar Source Type: research
Science of psychological phenomena and their testing
Am Psychol. 2024 May 6. doi: 10.1037/amp0001362. Online ahead of print.ABSTRACTThere is no crisis of replication and generalizability in psychological science, only misunderstanding or forgetting the fundamental nature of psychological phenomena and resultant implications for empirical testing. Stability-variability is the central feature of every psychological phenomenon, meaning that brain-mind interactions can only create stable patterns from which there will always be deviations. Psychological phenomena are not comparable to COVID-19 vaccines that were very effective (95%) initially for almost everyone for a long time....
Source: The American Psychologist - May 6, 2024 Category: Psychiatry & Psychology Authors: Seppo E Iso-Ahola Source Type: research
A psychological insight of Moroccan adults' immunisation behaviour towards emergency vaccines
CONCLUSION: These results reflect a positive perception and acceptance of vaccines, with a considerable level of stress regarding vaccination.Contribution: This study suggests emphasising the mental health of Moroccan young adults, to better sensitise and inform them about immunisation.PMID:38708727 | DOI:10.4102/phcfm.v16i1.4353 (Source: Primary Care)
Source: Primary Care - May 6, 2024 Category: Primary Care Authors: Nour El Houda Benkaddour Hind Khalil Asmae Lekfif Naima Abda Bouchra Oneib Yassamine Bentata Source Type: research
Self-management challenges of adults with type 2 diabetes mellitus in Ekurhuleni district primary health care facilities amid COVID-19 lockdown
CONCLUSION: The patients with T2DM experienced uncontrolled blood glucose levels and financial challenges during the COVID-19 lockdown. Guidelines to improve self-management programmes during restrictions are needed to promote good health during future pandemics to prevent complications and mortality. The telehealth model can be designed to monitor chronic patients at home during lockdown as a two-way communication.Contribution: More knowledge and insight into self-management and health promotion of patients with T2DM was provided by this study. Increased training needs arose for PHC nurses in managing and monitoring pati...
Source: Primary Care - May 6, 2024 Category: Primary Care Authors: Siphiwe S Mahlare Melitah M Rasweswe Thifhelimbilu I Ramavhoy Source Type: research
Determination of COVID-19 Late Disorders as Possible Long-COVID and/or Vaccination Consequences
This study included the vaccinated individuals of 4 different vaccine regimens including inactivated virus-based, subunit protein, and adenovirus-based vaccines in a follow-up schedule 6-month post the booster shot. All the documented vaccine adverse events were thoroughly assessed considering the cases' medical history by Adverse Events Committee of Pasteur Institute of Iran. Totally 329 individuals who got 3 doses of vaccination were followed 6 months after the booster shots among whom 41 (12.4%) cases with the mean age of 40.9 ± 10.48 years had a type of disorder. Gynecological and osteoarticular involvements were the ...
Source: Primary Care - May 6, 2024 Category: Primary Care Authors: Mona Sadat Larijani Anahita Bavand Mohammad Banifazl Fatemeh Ashrafian Ladan Moradi Amitis Ramezani Source Type: research
