Redox Biomarkers – An Effective Tool for Diagnosing COVID-19 Patients and Convalescents
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 26, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
The Effect of Guided Imagery and Progressive Muscle Relaxation on Sedation in Patients Undergoing Noninvasive Mechanical Ventilation
This study included 80 patients with a mean age (± SD) of 59.59 ± 9.27 years. The Quade nonparametric ANCOVA revealed the significant impact of intervention on the post values of Total score (p-value < 0.001), Tolerance (p-value < 0.001), Calmness (p-value < 0.001), Ventilator synchrony (p-value < 0.001), face relaxation (p-value < 0.001), Consciousness (p-value = 0.009) and Awakeness (p-value = 0.020). The study findings demonstrated the effectiveness of relaxation program in promoting sedation in patients undergoing NIV. Accordingly, intensive care unit (ICU) nurses at our institution are encouraged to u...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Atefe Salimi Akinabadi Sorour Khari Mehdi Azizmohammad Looha Mitra Zandi Source Type: research
The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research
Immunocompromised individuals are at increased risk of COVID ‐19 breakthrough infection, hospitalization, and death in the post‐vaccination era: A systematic review
ConclusionThis demonstrated that vaccination does not offer an adequate level of protection in these groups, necessitating further measures such as Evusheld and further boosters. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 26, 2024 Category: Allergy & Immunology Authors: Jola Bytyci,
Yuxin Ying,
Lennard Y. W. Lee Tags: REVIEW ARTICLE Source Type: research
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS ‐CoV‐2 spike protein as vaccine antigen in early process development
In this study, we analyze early process development data of recombinant trimeric spike protein Cumate-inducible manufacturing platform utilizing CHO stable pool as a preferred production host across three different stirred-tank bioreactor scales (0.75, 1, and 10 L). The impact of cell passage number as an indicator of cell age, methionine sulfoximine (MSX) concentration as a selection pressure, and cell seeding density was investigated using stable pools expressing three variants of concern. Multivariate data analysis with principal component analysis an d batch-wise unfolding technique was applied to evaluate the effec...
Source: Biotechnology Progress - April 26, 2024 Category: Biotechnology Authors: Sebastian ‐Juan Reyes,
Lucas Lemire,
Raul‐Santiago Molina,
Marjolaine Roy,
Helene L'Ecuyer‐Coelho,
Yuliya Martynova,
Brian Cass,
Robert Voyer,
Yves Durocher,
Olivier Henry,
Phuong Lan Pham Tags: RESEARCH ARTICLE Source Type: research
GSE185488 Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis in steady state and disease
Contributors : Florian Gaertner ; Anne Dueck ; Hellen Ishikawa-Ankerhold ; Susanne Stutte ; Michael Lorenz ; Steffen MassbergSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hematopoietic system gives rise to a heterogeneous population of terminally differentiated cells that reside in the bone marrow (BM) to fulfill their roles in immunity, blood clotting and tissue oxygenation. Hematopoietic stem and progenitor cells are at the apex of a hierarchically organized maturation cascade constantly replenishing the pool of differentiated cells to maintain blood cell homeostasis. Th...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Where are services regarding sexual minorities and psychological therapies post-COVID in 2024? A mixed-method systematised review
Matt Broadway-Horner Mental Health and Social Inclusion, Vol. ahead-of-print, No. ahead-of-print, pp.- Since COVID-19, many services have burgeoned within the UK, but what about sexual minorities? Since the last review, there are appropriate therapies, but there is often inadequate research. The purpose of this mixed-method review synthesis looking into the efficacy of psychological therapies for sexual minorities. Seven studies were found in total.A mixed-method review synthesis, three studies looking into the efficacy of psychological therapies for sexual minorities and four studies addressing the experiences of sexual ...
Source: Mental Health and Social Inclusion - April 26, 2024 Category: Psychiatry Authors: Matt Broadway-Horner Source Type: research
Viruses, Vol. 16, Pages 688: Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study
Conclusions: Our findings suggest that PASC promotes conditions that could result in decreased working ability and unemployment. These results highlight the significant impact of this syndrome on public health and the global economy, and the need to develop clinical pathways and guidelines for long-term care with specific focus on working impairment. (Source: Viruses)
Source: Viruses - April 26, 2024 Category: Virology Authors: Luisa Frallonardo Annunziata Ilenia Ritacco Angela Amendolara Domenica Cassano Giorgia Manco Cesari Alessia Lugli Mariangela Cormio Michele De Filippis Greta Romita Giacomo Guido Luigi Piccolomo Vincenzo Giliberti Francesco Cavallin Francesco Vladimiro Se Tags: Article Source Type: research
Viruses, Vol. 16, Pages 690: Challenges in Treating Pediatric Cancer Patients during the COVID-19 Pandemic: Balancing Risks and Care
es-Espíndola
The COVID-19 pandemic has resulted in millions of fatalities worldwide. The case of pediatric cancer patients stands out since, despite being considered a population at risk, few studies have been carried out concerning symptom detection or the description of the mechanisms capable of modifying the course of the COVID-19 disease, such as the interaction and response between the virus and the treatment given to cancer patients. By synthesizing existing studies, this paper aims to expose the treatment challenges for pediatric patients with COVID-19 in an oncology context. Additionally, this updated review i...
Source: Viruses - April 26, 2024 Category: Virology Authors: Ch ávez-Pacheco Castillejos-L ópez Laura M. Hern ández-Regino Velasco-Hidalgo Zapata-Tarres Correa-Carranza Rosario-M éndez Barrientos-R íos Aquino-G álvez Torres-Esp índola Tags: Review Source Type: research
Correction: Longitudinal analysis of home food production and food sharing behavior in Japan: multiple benefits of local food systems and the recent impact of the COVID-19 pandemic
(Source: Sustainability Science)
Source: Sustainability Science - April 26, 2024 Category: Science Source Type: research
Predicting oxygen needs in COVID-19 patients using chest radiography multi-region radiomics
The objective is to evaluate the performance of blood test results, radiomics, and a combination of the two data types on the prediction of the 24-h oxygenation support need for the Coronavirus disease 2019 (COVID-19) patients. In this retrospective cohort study, COVID-19 patients with confirmed real-time reverse transcription-polymerase chain reaction assay (RT-PCR) test results between February 2020 and August 2021 were investigated. Initial blood cell counts, chest radiograph, and the status of oxygenation support used within 24 h were collected (n = 290; mean age, 45 ± 19 years; 125 men). Radiomics features...
Source: Radiological Physics and Technology - April 26, 2024 Category: Physics Source Type: research
Telemedicine for adolescent and young adult long-acting reversible contraception post-insertion visits: outcomes over 1 year
Telemedicine for long-acting reversible contraception (LARC) care is understudied given the rapid implementation of these services in response to the COVID-19 pandemic. We compared outcomes over 1 year of adolescents and young adults (AYAs) attending a LARC post-insertion visit via telemedicine versus in person. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 26, 2024 Category: OBGYN Authors: Amanda E. Bryson, Carly E. Milliren, Sarah A. Golub, Sofya Maslyanskaya, Michelle Escovedo, Claudia Borzutzky, Sarah A.B. Pitts, Amy D. DiVasta Source Type: research
Effectiveness of BNT162b2 COVID-19 primary series vaccination in children aged 5 –17 years in the United States: a cohort study
This study ’s objective was to estimate the effectiveness of rece... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 26, 2024 Category: Pediatrics Authors: Rachel P. Ogilvie, J. Bradley Layton, Patricia C. Lloyd, Yixin Jiao, Djeneba Audrey Djibo, Hui Lee Wong, Joann F. Gruber, Ron Parambi, Jie Deng, Michael Miller, Jennifer Song, Lisa B. Weatherby, Lauren Peetluk, An-Chi Lo, Kathryn Matuska, Michael Wernecke Tags: Research Source Type: research
Cancers, Vol. 16, Pages 1673: COVID-19 and Cancer Detection in Russia
In this study, we analyzed the impact of the expected reduction in screening intensity on morbidity and mortality from certain malignancies. Cumulative data from the Russian National Cancer Registry available from 2000 to 2022 were analyzed. It was noted that there has been no noticeable effect of the COVID-19 lockdowns on mortality rates from breast, prostate, renal, or thyroid cancers. At the same time, the detectable incidence decreased markedly in 2020 at the time of the lockdowns and then returned to pre-pandemic levels in 2022. At the moment, there is no sufficient reason to believe that skipping screening tests in 2...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Andrey Sudarikov Tags: Communication Source Type: research
Viruses, Vol. 16, Pages 685: Impact of Prior COVID-19 Immunization and/or Prior Infection on Immune Responses and Clinical Outcomes
oglou
Cellular and humoral immunity exhibit dynamic adaptation to the mutating SARS-CoV-2 virus. It is noteworthy that immune responses differ significantly, influenced by whether a patient has received vaccination or whether there is co-occurrence of naturally acquired and vaccine-induced immunity, known as hybrid immunity. The different immune reactions, conditional on vaccination status and the viral variant involved, bear implications for inflammatory responses, patient outcomes, pathogen transmission rates, and lingering post-COVID conditions. Considering these developments, we have performed a review of recently ...
Source: Viruses - April 26, 2024 Category: Virology Authors: Achilleas Livieratos Charalambos Gogos Karolina Akinosoglou Tags: Review Source Type: research
