Complement system is overactivated in patients with IgA nephropathy after COVID-19
Clin Immunol. 2024 May 1:110232. doi: 10.1016/j.clim.2024.110232. Online ahead of print.ABSTRACTIgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics of patients with IgAN after COVID-19. The level of plasma level of C5a (p < 0.001), soluble C5b-9 (p = 0.018), FHR5 (p < 0.001) were all significantly higher in Group CoV (33 patients with renal biopsy-proven IgAN experienced COVID-19) compared with Group non-CoV (44 patients with IgAN without...
Source: Clinical Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Wei-Yi Guo Guo-Qin Wang Ling-Qiang Kong Li-Jun Sun Xiao-Yi Xu Wen-Rong Cheng Hong-Rui Dong Hong Cheng Source Type: research
Surgery for Central Nervous System Tuberculosis in Children
Adv Tech Stand Neurosurg. 2024;49:255-289. doi: 10.1007/978-3-031-42398-7_12.ABSTRACTTuberculosis (TB) is the second most common cause of death due to a single infectious agent worldwide after COVID-19. Central nervous system tuberculosis is widely prevalent in the world, especially in the developing countries and continues to be a socioeconomic problem. It is highly devastating form of tuberculosis leading to unacceptable levels of morbidity and mortality despite appropriate antitubercular therapy. The clinical symptoms are varied and nonspecific. They can be easily overlooked. Tuberculous meningitis is the most common pr...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: Dattatraya Muzumdar Puru Bansal Survender Rai Kushal Bhatia Source Type: research
Analysis of cases with co-infection of COVID-19 and pulmonary aspergillosis
This study included 201 COVID-19 patients from December 1, 2022, to January 31, 2023; 7 (3.5%) were diagnosed with CAPA. The main risk factors were age, MV, ICU admission and COPD, and the presence of comorbidities such as ARDS and hypoproteinemia in COVID-19 patients, more susceptible to Aspergillus infection. In addition to specimen culture in the lower respiratory tract, the 1,3-β-D-glucan antigen test can serve as an important screening indicator for early CAPA diagnosis in non-granulocytopenia patients.PMID:38700889 (Source: New Microbiologica)
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Hui Zheng Hu Li Bo Wu Qian Liu Bin Yan Wu Yu Wang Rui Ying Wang Source Type: research
Epidemiology and molecular characterization of respiratory viruses at the end of COVID-19 pandemic in Lombardy, Northern Italy
New Microbiol. 2024 May;47(1):80-87.ABSTRACTThe COVID-19 pandemic forced the adoption of non-pharmaceutical interventions (NPIs) which influenced the circulation of other respiratory pathogens, such as Influenza virus (FLU), Parainfluenza virus (PIV), Respiratory Syncytial virus (RSV), Rhinovirus (RV), Enterovirus (EV), Adenovirus (AdV), Human Metapneumovirus (hMPV), and Human Coronavirus (CoV). The aim of the current study was to investigate how, with the end of the pandemic, the withdrawal of the NPIs impacted on the circulation and distribution of common respiratory viruses. The analyzed samples were collected from June...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Leonardo Sclavi Marta Bertelli Serena Messali Arnaldo Caruso Francesca Caccuri Source Type: research
Tenofovir disoproxil fumarate in the treatment of COVID-19: Evaluation of 78 patients
New Microbiol. 2024 May;47(1):47-51.ABSTRACTOne of the drugs that has been suggested for the treatment of SARS-CoV-2 infection is tenofovir disoproxil (TDF). Herein, it was aimed to evaluate the outcomes of TDF receiving COVID-19 cases in terms of day 7-10 PCR negativity and day 30 survival. Patients who received TDF due to PCR-confirmed COVID-19 between 27.04.2021 and 31.12.2021 were included in our study. The primary outcome was considered to be 7-10 days of PCR negativity, while the secondary outcome was considered 30-day survival after diagnosis of COVID-19. Patients who died before completing the treatment period (7-1...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Gamze Şanlıdağ İşbilen Isabel Raika Durusoy Onmu ş Ilkin Çankayalı Kubilay Demira ğ Mehmet Uyar Candan Çiçek Tansu Yamazhan H üsnü Pullukçu O ğuz Reşat Sipahi Source Type: research
Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205787. Online ahead of print.ABSTRACTThe battle against the COVID-19 pandemic has spurred a heightened state of vigilance in global healthcare, leading to the proliferation of diverse sanitization methods. Among these approaches, germicidal lamps utilizing ultraviolet (UV) rays, particularly UV-C (wavelength ranging from 280 to 100 nm), have gained prominence for domestic use. These light-emitting diode (LED) lamps are designed to sanitize the air, objects, and surfaces. However, the prevailing concern is that these UV lamps are often introduced into the market without...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Nicola Alessio Alessia Ambrosino Andrea Boggi Domenico Aprile Iole Pinto Giovanni Galano Umberto Galderisi Giovanni Di Bernardo Source Type: research
Nirmatrelvir/ritonavir treatment of patients with COVID-19 taking tacrolimus: case series describing the results of drug-drug interactions
We describe the cases of two patients treated with nirmatrelvir/ritonavir: a patient who had undergone kidney transplantation and another with a history of hematopoietic stem cell transplantation. Toxic concentrations of tacrolimus were induced in both. This case series highlights the risk associated with the concomitant administration of tacrolimus and nirmatrelvir/ritonavir.PMID:38698526 | DOI:10.1177/03000605241247705 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Dan Shen Yinhua Gong Yulan Qian Jianguo Zhu Jie Gao Source Type: research
The End of the Beginning? Temporality and Bioagency in Pandemic Research
J Hist Med Allied Sci. 2024 May 3:jrae006. doi: 10.1093/jhmas/jrae006. Online ahead of print.ABSTRACTThis paper deals with the ways in which the intellectual and political history of AIDS can assist in the chronological conceptualization of a pandemic such as COVID-19 as it is unfolding. It problematizes the idea of pandemic "beginnings" and "ends" to show that such definitions are shaped by the disciplinary location and thematic foci of relevant scholars. Central to this analysis is the notion that ethical and political contexts affect research on a pandemic in different ways at national and global levels at various point...
Source: Medical History - May 3, 2024 Category: History of Medicine Authors: Mandisa Mbali Source Type: research
Surgical capacity is disaster preparedness: A scoping review of how surgery and anesthesiology departments responded to COVID-19
CONCLUSION: Our review reflects the mechanisms by which hospital surgical systems responded to the initial stress of the COVID-19 pandemic and reinforced the many changes to hospital policy that occurred in the pandemic. Healthcare systems with robust surgical systems were better able to cope with the initial stress of the COVID-19 pandemic. The well-resourced health systems of HICs reported rapid and dynamic changes by providers to assist in and ultimately improve the care of patients during the pandemic. Surgical system strengthening will allow health systems to be more resilient and prepared for the next disaster.PMID:3...
Source: American Journal of Disaster Medicine - May 3, 2024 Category: International Medicine & Public Health Authors: Matthew T Hey Madeleine Carroll Lili B Steel Mayte Bryce-Alberti Radzi Hamzah Rachel E Wittenberg Anam Ehsan Hodan Abdi Latoya Stewart Raina Parikh Raisa Rauf Jacqueline Cellini Kiana Winslow Isaac G Alty Craig D McClain Geoffrey A Anderson Source Type: research
Qualitative Study of Food Insecurity in Hospitalized Pediatric Patients during the COVID-19 Pandemic
CONCLUSIONS: The COVID-19 pandemic impacted unemployment and poverty and consequently exacerbated FI. Our findings point to the need to focus on proximal societal solutions, such as federal policies aimed at food assistance and childcare. Understanding the challenges related to FI that caregivers and patients experience can improve screening, support, and treatment of patients presenting for care and inform the design of necessary interventions for individuals and communities beyond COVID-19.PMID:38701847 | DOI:10.14423/SMJ.0000000000001684 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Natalie King Adolfo Molina Samantha Hanna Lori Brand Bateman Source Type: research
Effects of Preoperative COVID-19 Status on Emergent or Urgent Colectomy Outcomes
CONCLUSIONS: Urgent or emergent colectomy patients who were COVID-19+ preoperatively were more likely to present with comorbidities, which, along with the recent viral infection, contributed to markedly worse clinical outcomes, including an increased rate of mortality.PMID:38701852 | DOI:10.14423/SMJ.0000000000001682 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Satyam K Ghodasara Grace C Chang Justin S Roskam Sara S Soliman Kaitlyn Oldewurtel Rolando H Rolandelli Zoltan H Nemeth Source Type: research
COVID-19 Vaccine Information and Infertility Posts on X: Insights on a Misinformation Pandemic
CONCLUSIONS AND RELEVANCE: Misinformation about the COVID-19 vaccine and fertility is highly prevalent on X and threatens vaccine uptake in patients desiring future fertility. Accounts sharing factual information were likely to have more followers and be verified; therefore, verifying more physicians sharing accurate information is critical.PMID:38698715 | DOI:10.7812/TPP/23.142 (Source: The Permanente journal)
Source: The Permanente journal - May 3, 2024 Category: General Medicine Authors: Morgan S Levy Kelby N Hunt Sarah Rinehart Alyssa D Brown Amelia G Kelly Padmaja Sundaram Alisha Crump Tiffany J Sinclair Kally Dey Alexander Zoroufy Alberto J Caban-Martinez Torie Comeaux Plowden Source Type: research
Did a workplace sugar-sweetened beverage sales ban reduce anxiety-related SSB consumption during the COVID-19 pandemic?
CONCLUSIONS: SSB sales bans likely reduce SSB consumption through multiple pathways; buffering stress-related consumption may be one mechanism.PMID:38698591 | DOI:10.1017/S1368980024000995 (Source: Public Health Nutrition)
Source: Public Health Nutrition - May 3, 2024 Category: International Medicine & Public Health Authors: Laurie M Jacobs Laura A Schmidt Dean Schillinger Jamey M Schmidt Katie E Alegria Bethany Parrett Amanda Pickett Elissa S Epel Source Type: research
Predicting Food Insecurity Among UK University Students During the COVID-19 Pandemic
CONCLUSIONS: Both economic factors and illness play a significant role in self-reported food insecurity in higher education students during pandemic lockdown. Further research is needed to explore food insecurity, economic factors, and illness outside of a pandemic context.PMID:38698611 | DOI:10.1017/S1368980024001022 (Source: Public Health Nutrition)
Source: Public Health Nutrition - May 3, 2024 Category: International Medicine & Public Health Authors: Emily K Round Sarah Weatherston Paul B Stretesky Margaret Anne Defeyter Source Type: research
Lifestyle, meal times, and sleep patterns changes in higher education professors during COVID-19: Association with non-communicable chronic diseases
CONCLUSION: The results provide data that can help in the development of public policies that promote health actions to minimize the consequences associated with the pandemic period.PMID:38701123 | DOI:10.3233/WOR-230518 (Source: Work)
Source: Work - May 3, 2024 Category: Occupational Health Authors: Caroline Pereira Garc ês Camila Faleiros Veloso Soares T ássia Magnabosco Sisconeto Guilherme Cabral Borges Martins Marina Abreu Dias Rafaella Andrade Vivenzio Thiago Ferreira Moreira Yanne da Silva Camargo Cibele Aparecida Crispim Laura Cristina Tibile Source Type: research
