Automated liver volumetry and hepatic steatosis quantification with magnetic resonance imaging proton density fat fraction
CONCLUSION: Automated ME-Dixon MRI liver volumetry and MRI-PDFF were strongly correlated with CT liver volumetry and MRS hepatic steatosis measurements, especially in donors with hepatic steatosis.PMID:38643056 | DOI:10.1016/j.jfma.2024.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 20, 2024 Category: General Medicine Authors: Yuan-Chen Chang Kuang-Chen Yen Po-Chin Liang Ming-Chih Ho Cheng-Maw Ho Chih-Yang Hsiao Chiu-Han Hsiao Chia-Hsun Lu Chih-Horng Wu Source Type: research
Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA
In this study, we developed chemo-photothermal therapy (chemo-PTT) based on near-infrared (NIR)-irradiated chitosan/gold nanorod (GNR) clusters as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. The nanocomposites exhibited an average size of 223 nm with a surface charge of 36 mV. These plasmonic nanocomposites demonstrated on-demand and rapid hyperthermal action under NIR. The combined effect of positive charge and PTT by NIR-irradiated nanocomposites resulted in a remarkable inhibition rate of 96 % against planktonic MRSA, indicating a synergistic activity compared to chitosan nanoparticles or GNR alone. ...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: G R Nirmal Zih-Chan Lin Tai-Sheng Chiu Ahmed Alalaiwe Chia-Chih Liao Jia-You Fang Source Type: research
The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial
This study examines the oral health benefits of heat-killed Lacticaseibacillus paracasei GMNL-143, particularly its potential in oral microbiota alterations and gingivitis improvement. (Source: BMC Oral Health)
Source: BMC Oral Health - April 20, 2024 Category: Dentistry Authors: Min-Kang Lee, I-Hui Chen, I-Ling Hsu, Wan-Hua Tsai, Tzong-Yi Lee, Jhih-Hua Jhong, Bai-Chia Liu, Tsui-Yin Huang, Fang-Kuei Lin, Wen-Wei Chang and Ju-Hui Wu Tags: Research Source Type: research
Seronegative patients with primary Sj ögren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva
CONCLUSION: Our findings suggest that salivary anti-SSA/Ro antibodies are potential discriminatory biomarkers for pSS, which may also identify seronegative patients, addressing the unmet clinical need of early detection and stratification of pSS.PMID:38641012 | DOI:10.1016/j.bbadis.2024.167168 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 19, 2024 Category: Biochemistry Authors: Sarah Kamounah Fang Wei Jin Kyun Park Yeong-Wook Song David Chia David T W Wong Anne Marie Lynge Pedersen Source Type: research
Biological evaluation of sulfonate and sulfate analogues of lithocholic acid: A bioisosterism-guided approach towards the discovery of potential sialyltransferase inhibitors for antimetastatic study
Bioorg Med Chem Lett. 2024 Apr 17;105:129760. doi: 10.1016/j.bmcl.2024.129760. Online ahead of print.ABSTRACTThe naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sia...
Source: Bioorganic and Medicinal Chemistry Letters - April 19, 2024 Category: Chemistry Authors: Ser John Lynon P Perez Chia-Ling Chen Tzu-Ting Chang Wen-Shan Li Source Type: research
Representativeness of the PIONEER ‐HF and PARAGLIDE‐HF in patients hospitalized with acute heart failure
ConclusionsUsing trial criteria, only 31.3% of AHF patients were eligible for sacubitril –valsartan. Yet, non-eligible patients demonstrated similar outcomes to eligible patients, indicating a need for further evaluation of sacubitril–valsartan benefits in non-eligible AHF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Dong ‐Yi Chen,
Chun‐Chi Chen,
Cheng‐Hung Lee,
Chi‐Nan Tseng,
Shao‐Wei Chen,
Shang‐Hung Chang,
Tien‐Hsing Chen,
Pao‐Hsien Chu,
I‐Chang Hsieh,
Ming‐Shien Wen,
Ming‐Lung Tsai,
Ming‐Jer Hsieh Tags: Original Article Source Type: research
Growth of shared book reading in the first two years and its effects on children ’s development
. (Source: Applied Developmental Science)
Source: Applied Developmental Science - April 19, 2024 Category: Child Development Authors: Chia-Hui LinChien-Ju ChangHsi-Ping NiehNational Taiwan Normal University Source Type: research
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NF κB pro-inflammatory pathway and intracellular ROS generation
In conclusion, 3-BrFlu is a hazardous substance that results in vascular endothelial dysfunction through the MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation.PMID:38635053 | DOI:10.1007/s00204-024-03751-0 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 18, 2024 Category: Toxicology Authors: Chien-Ying Lee Sheng-Wen Wu Jiann-Jou Yang Wen-Ying Chen Chun-Jung Chen Hsin-Hung Chen Yi-Chia Lee Chun-Hung Su Yu-Hsiang Kuan Source Type: research
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NF κB pro-inflammatory pathway and intracellular ROS generation
In conclusion, 3-BrFlu is a hazardous substance that results in vascular endothelial dysfunction through the MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation.PMID:38635053 | DOI:10.1007/s00204-024-03751-0 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 18, 2024 Category: Toxicology Authors: Chien-Ying Lee Sheng-Wen Wu Jiann-Jou Yang Wen-Ying Chen Chun-Jung Chen Hsin-Hung Chen Yi-Chia Lee Chun-Hung Su Yu-Hsiang Kuan Source Type: research
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NF κB pro-inflammatory pathway and intracellular ROS generation
In conclusion, 3-BrFlu is a hazardous substance that results in vascular endothelial dysfunction through the MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation.PMID:38635053 | DOI:10.1007/s00204-024-03751-0 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 18, 2024 Category: Toxicology Authors: Chien-Ying Lee Sheng-Wen Wu Jiann-Jou Yang Wen-Ying Chen Chun-Jung Chen Hsin-Hung Chen Yi-Chia Lee Chun-Hung Su Yu-Hsiang Kuan Source Type: research
The noncanonical NF κB pathway: Regulatory mechanisms in health and disease
This article is categorized under:
Immune System Diseases> Molecular and Cellular Physiology
Cancer> Molecular and Cellular Physiology
Immune System Diseases> Stem Cells and Development (Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine)
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - April 18, 2024 Category: Biomedical Science Authors: Benancio N. Rodriguez,
Helen Huang,
Jennifer J. Chia,
Alexander Hoffmann Tags: Advanced Review Source Type: research
Salt reduction policy for out of home sectors: a supplementary document for the salt reduction strategy to prevent and control non-communicable diseases (NCDS) in Malaysia 2021 –2025
Cardiovascular diseases (CVDs) are the major cause of death among Malaysians. Reduction of salt intake in populations is one of the most cost-effective strategies in the prevention of CVDs. It is very feasible... (Source: Health Research Policy and Systems)
Source: Health Research Policy and Systems - April 18, 2024 Category: International Medicine & Public Health Authors: Zaliha Harun, Suzana Shahar, Yee Xing You, Zahara Abdul Manaf, Hazreen Abdul Majid, Chia Yook Chin, Hasnah Haron, Viola Michael, Hamdan Mohamad, Siti Farrah Zaidah Mohd Yazid, Musaalbakri Abdul Manan, Wan Zunairah Wan Ibadullah, Mhairi K. Brown, Feng J. H Tags: Opinion Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Am J Pathol. 2024 Apr 15:S0002-9440(24)00132-9. doi: 10.1016/j.ajpath.2024.02.023. Online ahead of print.ABSTRACTSince the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pan...
Source: Am J Pathol - April 17, 2024 Category: Pathology Authors: Li-Yun Ding Chia-Jung Chang Szu-Ying Chen Kuan-Lin Chen Yueh-Shan Li Yun-Chieh Wu Ting-Yi Hsu Hsin-Yu Ying Hsin-Yi Wu Michael W Hughes Chia-Yih Wang Chih-Han Chang Ming-Jer Tang Woei-Jer Chuang Yan-Shen Shan Chia-Jung Chang Po-Hsien Huang Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Am J Pathol. 2024 Apr 15:S0002-9440(24)00132-9. doi: 10.1016/j.ajpath.2024.02.023. Online ahead of print.ABSTRACTSince the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pan...
Source: The American Journal of Pathology - April 17, 2024 Category: Pathology Authors: Li-Yun Ding Chia-Jung Chang Szu-Ying Chen Kuan-Lin Chen Yueh-Shan Li Yun-Chieh Wu Ting-Yi Hsu Hsin-Yu Ying Hsin-Yi Wu Michael W Hughes Chia-Yih Wang Chih-Han Chang Ming-Jer Tang Woei-Jer Chuang Yan-Shen Shan Chia-Jung Chang Po-Hsien Huang Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Am J Pathol. 2024 Apr 15:S0002-9440(24)00132-9. doi: 10.1016/j.ajpath.2024.02.023. Online ahead of print.ABSTRACTSince the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pan...
Source: Am J Pathol - April 17, 2024 Category: Pathology Authors: Li-Yun Ding Chia-Jung Chang Szu-Ying Chen Kuan-Lin Chen Yueh-Shan Li Yun-Chieh Wu Ting-Yi Hsu Hsin-Yu Ying Hsin-Yi Wu Michael W Hughes Chia-Yih Wang Chih-Han Chang Ming-Jer Tang Woei-Jer Chuang Yan-Shen Shan Chia-Jung Chang Po-Hsien Huang Source Type: research
