Fabrication and characterization of emulsion-based edible film containing cinnamon essential oil using chia seed mucilage
Int J Biol Macromol. 2024 Mar 28:131173. doi: 10.1016/j.ijbiomac.2024.131173. Online ahead of print.ABSTRACTChia seed mucilage (CSM) film incorporated with 2, 4, and 6 % (w/w) nanoemulsion of cinnamon essential oil (CSM-2, CSM-4, CSM-6) were developed, and their physicochemical, mechanical, antioxidant, and antimicrobial properties were determined. According to the results, cinnamon EO nanoemulsion (CEN) had droplet size 196.07 ± 1.39 nm with PDI 0.47 ± 0.04. Moreover, CSM film had higher water solubility (99.37 ± 0.05 %) and WVP (8.55 ± 1.10 g/kPa h m2) than reinforced CSM films with CENCEN. The lowest water solubilit...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Elahe Abedi Mehran Sayadi Najmeh Oliyaei Source Type: research
Soluble tumor necrosis factor receptor type 1 is an alternative marker of urinary albumin-creatinine ratio and estimated glomerular filtration rate for predicting the decline of renal function in subjects with type 2 diabetes mellitus
CONCLUSION: sTNFR1 could be an alternative marker for identifying patients with diabetes at risk of declining renal function.PMID:38555050 | DOI:10.1016/j.cca.2024.117880 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 30, 2024 Category: Chemistry Authors: Li-Hsin Chang Ting-Ting Chang Chia-Huei Chu Chin-Chou Huang Liang-Yu Lin Source Type: research
Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors
Antiviral Res. 2024 Mar 28:105874. doi: 10.1016/j.antiviral.2024.105874. Online ahead of print.ABSTRACTThe main protease (MPro) of SARS-CoV-2, the causative agent of COVID-19, is a pivotal nonstructural protein critical for viral replication and pathogenesis. Its protease function relies on three active site pockets for substrate recognition and a catalytic cysteine for enzymatic activity. To develop potential SARS-CoV-2 antivirals, we successfully synthesized a diverse range of azapeptide inhibitors with various covalent warheads to target MPro's catalytic cysteine. Our characterization identified potent MPro inhibitors, ...
Source: Antiviral Research - March 30, 2024 Category: Virology Authors: Kaustav Khatua Yugendar R Alugubelli Kai S Yang Veerabhadra R Vulupala Lauren R Blankenship Demonta Coleman Sandeep Atla Sankar P Chaki Zhi Zachary Geng Xinyu R Ma Jing Xiao Peng-Hsun Chen Chia-Chuan D Cho Shivangi Sharma Erol C Vatansever Yuying Ma Ge Yu Source Type: research
The factors impacting on Gleason score upgrading in prostate cancer with initial low Gleason scores
CONCLUSIONS: Smaller PV and elevated PSAD are associated with increased risk of GS upgrading, whereas lead-time bias is not. A cut-off value of PV < 38 ml and PSAD > 0.26 ng/ml2 were further identified to be associated with pathological GS upgrading.PMID:38555188 | DOI:10.1016/j.jfma.2024.03.014 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - March 30, 2024 Category: General Medicine Authors: Tzu-Heng Huang Wei-Ming Li Hung-Lung Ke Ching-Chia Li Wen-Jeng Wu Hsin-Chih Yeh Yen-Chun Wang Hsiang-Ying Lee Source Type: research
The factors impacting on Gleason score upgrading in prostate cancer with initial low Gleason scores
CONCLUSIONS: Smaller PV and elevated PSAD are associated with increased risk of GS upgrading, whereas lead-time bias is not. A cut-off value of PV < 38 ml and PSAD > 0.26 ng/ml2 were further identified to be associated with pathological GS upgrading.PMID:38555188 | DOI:10.1016/j.jfma.2024.03.014 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - March 30, 2024 Category: General Medicine Authors: Tzu-Heng Huang Wei-Ming Li Hung-Lung Ke Ching-Chia Li Wen-Jeng Wu Hsin-Chih Yeh Yen-Chun Wang Hsiang-Ying Lee Source Type: research
Predictors of tumour dynamics over a 6-week course of concurrent chemoradiotherapy for glioblastoma and the impact on survival
We present the final analyses of tumour dynamics and their prognostic significance during a 6-week course of concurrent chemoradiotherapy (chemoRT) for glioblastoma (GBM) in the GLIO study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 30, 2024 Category: Radiology Authors: Wee Loon Ong, James Stewart, Arjun Sahgal, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Ling Ho, Sunit Das, Pejman Maralani, Nir Lipsman, Greg Stanisz, James Perry, Mary Jane Lim-Fat, Eshetu G Atenafu, Angus Lau, Mark Ruschin, Sten Myrehaug Tags: Clinical Investigation Source Type: research
Focused ultrasound-mediated blood –brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma
Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 30, 2024 Category: Research Authors: Masih Tazhibi, Nicholas McQuillan, Hong-Jian Wei, Matthew Gallitto, Ethan Bendau, Andrea Webster Carrion, Xander Berg, Danae Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, Akiva Mintz, Robyn D. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic & h Tags: Research Source Type: research
MicroRNA ‑155‑5p inhibits trophoblast cell proliferation and invasion by disrupting centrosomal function
In conclusion, the present study indicated a novel role of miR‑55‑5p in mediating centrosomal function in recurrent miscarriage.PMID:38551159 | DOI:10.3892/mmr.2024.13209 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Yung-Chieh Tsai Tian-Ni Kuo Ruei-Ci Lin Hui-Ling Tsai Yu-Ying Chao Pei-Rong Lee Ping-Jui Su Chia-Yih Wang Source Type: research
MicroRNA ‑155‑5p inhibits trophoblast cell proliferation and invasion by disrupting centrosomal function
In conclusion, the present study indicated a novel role of miR‑55‑5p in mediating centrosomal function in recurrent miscarriage.PMID:38551159 | DOI:10.3892/mmr.2024.13209 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Yung-Chieh Tsai Tian-Ni Kuo Ruei-Ci Lin Hui-Ling Tsai Yu-Ying Chao Pei-Rong Lee Ping-Jui Su Chia-Yih Wang Source Type: research
MicroRNA ‑155‑5p inhibits trophoblast cell proliferation and invasion by disrupting centrosomal function
In conclusion, the present study indicated a novel role of miR‑55‑5p in mediating centrosomal function in recurrent miscarriage.PMID:38551159 | DOI:10.3892/mmr.2024.13209 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Yung-Chieh Tsai Tian-Ni Kuo Ruei-Ci Lin Hui-Ling Tsai Yu-Ying Chao Pei-Rong Lee Ping-Jui Su Chia-Yih Wang Source Type: research
MicroRNA ‑155‑5p inhibits trophoblast cell proliferation and invasion by disrupting centrosomal function
In conclusion, the present study indicated a novel role of miR‑55‑5p in mediating centrosomal function in recurrent miscarriage.PMID:38551159 | DOI:10.3892/mmr.2024.13209 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Yung-Chieh Tsai Tian-Ni Kuo Ruei-Ci Lin Hui-Ling Tsai Yu-Ying Chao Pei-Rong Lee Ping-Jui Su Chia-Yih Wang Source Type: research
